Psychiatric Survivors & Experiential Rights

Human rights may be categorised as belonging to ‘three generations’: political, social and ‘solidarity’ rights. This paper considers this schema theoretically, deploying the example of the ‘psychiatric survivor’ movement in Britain in support of its central claims. Psychiatric survivors comprise groups of psychiatric patients who have campaigned both for political and social rights in addition to a singular form of ‘right’, which is referred to here as ‘experiential’. The paper clarifies the meaning of the ‘experiential right’ and, drawing upon aspects of social theory, considers how it is to be understood in the context of the ‘three generations’ schema

Medical conditions in autism spectrum disorders

Autism spectrum disorder (ASD) is a behaviourally defined syndrome where the etiology and pathophysiology is only partially understood. In a small proportion of children with the condition, a specific medical disorder is identified, but the causal significance in many instances is unclear. Currently, the medical conditions that are best established as probable causes of ASD include Fragile X syndrome, Tuberous Sclerosis and abnormalities of chromosome 15 involving the 15q11-13 region. Various other single gene mutations, genetic syndromes, chromosomal abnormalities and rare de novo copy number variants have been reported as being possibly implicated in etiology, as have several ante and post natal exposures and complications. However, in most instances the evidence base for an association with ASD is very limited and largely derives from case reports or findings from small, highly selected and uncontrolled case series. Not only therefore, is there uncertainty over whether the condition is associated, but the potential basis for the association is very poorly understood. In some cases the medical condition may be a consequence of autism or simply represent an associated feature deriving from an underlying shared etiology. Nevertheless, it is clear that in a growing proportion of individuals potentially causal medical conditions are being identified and clarification of their role in etio-pathogenesis is necessary. Indeed, investigations into the causal mechanisms underlying the association between conditions such as tuberous sclerosis, Fragile X and chromosome 15 abnormalities are beginning to cast light on the molecular and neurobiological pathways involved in the pathophysiology of ASD. It is evident therefore, that much can be learnt from the study of probably causal medical disorders as they represent simpler and more tractable model systems in which to investigate causal mechanisms. Recent advances in genetics, molecular and systems biology and neuroscience now mean that there are unparalleled opportunities to test causal hypotheses and gain fundamental insights into the nature of autism and its development

A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes

dentification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD). A combined T1D+T2D GWAS was performed using complementary data available for subjects with T1D, which, with replication samples, involved up to 40,340 subjects with diabetes (18,582 with DKD). Analysis of specific DKD phenotypes identified a novel signal near GABRR1 (rs9942471, P = 4.5 x 10(-8)) associated with microalbuminuria in European T2D case subjects. However, no replication of this signal was observed in Asian subjects with T2D or in the equivalent T1D analysis. There was only limited support, in this substantially enlarged analysis, for association at previously reported DKD signals, except for those at UMOD and PRKAG2, both associated with estimated glomerular filtration rate. We conclude that, despite challenges in addressing phenotypic heterogeneity, access to increased sample sizes will continue to provide more robust inference regarding risk variant discovery for DKD.Peer reviewe

Developing a Method to Create Optimal Milk Runs : A Study at Volvo Construction Equipment, Arvika

Validerat; 20160621 (global_studentproject_submitter

Modelling and valuing ecosystem goods and services of multifunctional landscapes using GIS and remote sensing

Landscape change today is occurring more rapidly than in any other time in history. Among other influences such as global warming these changes are also driven by political decisions affecting ecosystem services. The overall research objective is to defi ne how the European Union’s political strategies implemented through rural development programmes and the Common Agricultural Policy (CAP) are infl uencing or changing ecosystem goods and services in the future. This contribution aims at outlining the research framework and especially focuses on a ground rent approach to model the spatially explicit distribution of subsidy cash fl ows on farm and parcel level. Experiments with changing political strategies and incentive payments were carried out in the Mondsee catchment (Austria) using GIS and remote sensing for facilitation. The results were visualised and show the dominant (inter-)national and regional funding programmes of this area. They further display the likely effects of changing political strategies on the monetary value of certain parcels and the overall farmparcel balance. The validation of an aggregated set of funding measures reveals 15% deviation between the model framework and real subsidy payments. Thus, this model is suitable for estimating the impact of changed funding strategies at EU level and also supports farmers in indentifying the best economic income sources on parcel and farm level. Embedded in the overall research objective, the results constitute the basis for opening a discussion on how ecosystem services might change with political intervention strategies in rural areas and resulting landscape changes in the future