High-density magnetomyography is superior to high-density surface electromyography for motor unit decomposition: a simulation study

Objective. Studying motor units is essential for understanding motor control, the detection of neuromuscular disorders and the control of human-machine interfaces. Individual motor unit firings are currently identified in vivo by decomposing electromyographic (EMG) signals. Due to our body’s properties and anatomy, individual motor units can only be separated to a limited extent with surface EMG. Unlike electrical signals, magnetic fields do not interact with human tissues. This physical property and the emerging technology of quantum sensors make magnetomyography (MMG) a highly promising methodology. However, the full potential of MMG to study neuromuscular physiology has not yet been explored. Approach. In this work, we perform in silico trials that combine a biophysical model of EMG and MMG with state-of-the-art algorithms for the decomposition of motor units. This allows the prediction of an upper-bound for the motor unit decomposition accuracy. Main results. It is shown that non-invasive high-density MMG data is superior over comparable high-density surface EMG data for the robust identification of the discharge patterns of individual motor units. Decomposing MMG instead of EMG increased the number of identifiable motor units by 76%. Notably, MMG exhibits a less pronounced bias to detect superficial motor units. Significance. The presented simulations provide insights into methods to study the neuromuscular system non-invasively and in vivo that would not be easily feasible by other means. Hence, this study provides guidance for the development of novel biomedical technologies

The SVOM gamma-ray burst mission

We briefly present the science capabilities, the instruments, the operations, and the expected performance of the SVOM mission. SVOM (Space-based multiband astronomical Variable Objects Monitor) is a Chinese-French space mission dedicated to the study of Gamma-Ray Bursts (GRBs) in the next decade. The SVOM mission encompasses a satellite carrying four instruments to detect and localize the prompt GRB emission and measure the evolution of the afterglow in the visible band and in X-rays, a VHF communication system enabling the fast transmission of SVOM alerts to the ground, and a ground segment including a wide angle camera and two follow-up telescopes. The pointing strategy of the satellite has been optimized to favor the detection of GRBs located in the night hemisphere. This strategy enables the study of the optical emission in the first minutes after the GRB with robotic observatories and the early spectroscopy of the optical afterglow with large telescopes to measure the redshifts. The study of GRBs in the next decade will benefit from a number of large facilities in all wavelengths that will contribute to increase the scientific return of the mission. Finally, SVOM will operate in the era of the next generation of gravitational wave detectors, greatly contributing to searches for the electromagnetic counterparts of gravitational wave triggers at Xray and gamma-ray energies.Comment: 13 pages, 5 figures, published by PoS, proceedings of the conference Swift: 10 Years of Discovery, 2-5 December 2014, La Sapienza University, Rome, Ital

Rapid detection of human blood in triatomines (kissing bugs) utilizing a lateral flow immunochromatographic assay - A pilot study

BACKGROUND DNA- and proteomics-based techniques are currently used to identify a triatomine human blood meal. These methods are time consuming, require access to laboratories with sophisticated equipment, and trained personnel. OBJECTIVES We tested a rapid and specific immunochromatographic assay (that detects human blood in forensic samples) to determine if human blood was present in triatomines and their fecal excreta. METHODS We fed Triatoma rubida human blood (positive control) or mouse blood (negative control) and performed the assay on the abdominal contents and fecal excreta. Triatomine field specimens collected in and around human habitations and excreta were also tested. FINDINGS The assay was positive in triatomines fed human blood (N = 5/5) and fecal excreta from bugs known to have ingested human blood (N = 5/5). Bugs feeding on mice (N = 15/15) and their fecal excreta (N = 8/8) were negative for human blood. Human blood was detected in 47% (N = 23/49) triatomines, representing six different species, collected in the field. MAIN CONCLUSIONS The pilot study shows that this rapid and specific test may have applications in triatomine research. Further study is needed to determine the sensitivity of this assay compared to other well-established techniques, such as DNA- and proteomics-based methodologies and the assay's application in the field.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

Absence of lattice strain anomalies at the electronic topological transition in zinc at high pressure

High pressure structural distortions of the hexagonal close packed (hcp) element zinc have been a subject of controversy. Earlier experimental results and theory showed a large anomaly in lattice strain with compression in zinc at about 10 GPa which was explained theoretically by a change in Fermi surface topology. Later hydrostatic experiments showed no such anomaly, resulting in a discrepancy between theory and experiment. We have computed the compression and lattice strain of hcp zinc over a wide range of compressions using the linearized augmented plane wave (LAPW) method paying special attention to k-point convergence. We find that the behavior of the lattice strain is strongly dependent on k-point sampling, and with large k-point sets the previously computed anomaly in lattice parameters under compression disappears, in agreement with recent experiments.Comment: 9 pages, 6 figures, Phys. Rev. B (in press

The ECLAIRs micro-satellite mission for gamma-ray burst multi-wavelength observations

Gamma-ray bursts (GRB), at least those with a duration longer than a few seconds are the most energetic events in the Universe and occur at cosmological distances. The ECLAIRs micro-satellite, to be launched in 2009, will provide multi-wavelength observations of GRB, to study their astrophysics and to use them as cosmological probes. Furthermore in 2009 ECLAIRs is expected to be the only space borne instrument capable of providing a GRB trigger in near real-time with sufficient localization accuracy for GRB follow-up observations with the powerful ground based spectroscopic telescopes available by then. A "Phase A study" of the ECLAIRs project has recently been launched by the French Space Agency CNES, aiming at a detailed mission design and selection for flight in 2006. The ECLAIRs mission is based on a CNES micro-satellite of the "Myriade" family and dedicated ground-based optical telescopes. The satellite payload combines a 2 sr field-of-view coded aperture mask gamma-camera using 6400 CdTe pixels for GRB detection and localization with 10 arcmin precision in the 4 to 50 keV energy band, together with a soft X-ray camera for onboard position refinement to 1 arcmin. The ground-based optical robotic telescopes will detect the GRB prompt/early afterglow emission and localize the event to arcsec accuracy, for spectroscopic follow-up observations.Comment: 7 pages, 1 figure, proceedings of the conference "New Developments in Photodetection", Beaune (France), June 25005. Submitted to NIM-A (Elsevier Science

Electrophysiological activation by masked primes: Independence of prime-related and target-related activities

Visual stimuli that are made invisible by metacontrast masking (primes) have a marked influence on behavioral and psychophysiological measures such as reaction time (RT) and the lateralized readiness potential (LRP). 4 experiments are reported that shed light on the effects that masked primes have on the LRP. Participants had a go-nogo task in which the prime was associated with 1 of 2 responses even if the target required participants to refrain from responding. To analyze the electrophysiological responses, we computed the LRP and applied an averaging method separating the activation due to the prime and the target. The results demonstrated that (a) masked primes activate responses even in a nogo situation, (b) this prime-related activation is independent of masking, (c) and is also independent of whether prime and target require the same responses (congruent condition) or different responses (incongruent condition)

ESUR prostate MR guidelines 2012

The aim was to develop clinical guidelines for multi-parametric MRI of the prostate by a group of prostate MRI experts from the European Society of Urogenital Radiology (ESUR), based on literature evidence and consensus expert opinion. True evidence-based guidelines could not be formulated, but a compromise, reflected by “minimal” and “optimal” requirements has been made. The scope of these ESUR guidelines is to promulgate high quality MRI in acquisition and evaluation with the correct indications for prostate cancer across the whole of Europe and eventually outside Europe. The guidelines for the optimal technique and three protocols for “detection”, “staging” and “node and bone” are presented. The use of endorectal coil vs. pelvic phased array coil and 1.5 vs. 3 T is discussed. Clinical indications and a PI-RADS classification for structured reporting are presented

Pressure Dependence of the Irreversibility Line in Bi2_{2}Sr2_{2}CaCu2_{2}O8+δ_{8+\delta}:Role of Anisotropy in Flux-Line Formation

One of the important problems of high-temperature superconductivity is to understand and ultimately to control fluxoid motion. We present the results of a new technique for measuring the pressure dependence of the transition to superconductivity in a diamond anvil cell. By measuring the third harmonic of the {\it ac} susceptibility, we determine the onset of irreversible flux motion. This enables us to study the effects of pressure on flux motion. The application of pressure changes interplanar spacing, and hence the interplanar coupling, without significantly disturbing the intraplanar superconductivity. Thus we are able to separate the effects of coupling from other properties that might affect the flux motion. Our results directly show the relationship between lattice spacing, effective- mass anisotropy, and the irreversibility line in Bi$_{2}$Sr$_{2}$CaCu$_{2}$O$_{8+\delta}$. Our results also demonstrate that an application of 2.5 GPa pressure causes a dramatic increase in interplanar coupling.Comment: 4 pages, 4 figure