Sleep drive reconfigures wake-promoting clock circuitry to regulate adaptive behavior

Circadian rhythms help animals synchronize motivated behaviors to match environmental demands. Recent evidence indicates that clock neurons influence the timing of behavior by differentially altering the activity of a distributed network of downstream neurons. Downstream circuits can be remodeled by Hebbian plasticity, synaptic scaling, and, under some circumstances, activity-dependent addition of cell surface receptors; the role of this receptor respecification phenomena is not well studied. We demonstrate that high sleep pressure quickly reprograms the wake-promoting large ventrolateral clock neurons to express the pigment dispersing factor receptor (PDFR). The addition of this signaling input into the circuit is associated with increased waking and early mating success. The respecification of PDFR in both young and adult large ventrolateral neurons requires 2 dopamine (DA) receptors and activation of the transcriptional regulator nejire (cAMP response element-binding protein [CREBBP]). These data identify receptor respecification as an important mechanism to sculpt circuit function to match sleep levels with demand

GRB afterglow light curves in the pre-Swift era - a statistical study

We present the results of a systematic analysis of the world sample of optical/near-infrared afterglow light curves observed in the pre-Swift era by the end of 2004. After selecting the best observed 16 afterglows with well-sampled light curves that can be described by a Beuermann equation, we explore the parameter space of the light curve parameters and physical quantities related to them. In addition, we search for correlations between these parameters and the corresponding gamma-ray data, and we use our data set to look for a fine structure in the light curves.Comment: accepted for publication in ApJ; Version 2: minor changes, one figure adde

Another short-burst host galaxy with an optically obscured high star formation rate: The case of GRB 071227

We report on radio continuum observations of the host galaxy of the short gamma-ray burst 071227 (z=0.381) with the Australia Telescope Compact Array (ATCA). We detect the galaxy in the 5.5 GHz band with an integrated flux density of Fnu = 43 +/- 11 microJy, corresponding to an unobscured star-formation rate (SFR) of about 24 Msun/yr, forty times higher than what was found from optical emission lines. Among the ~30 well-identified and studied host galaxies of short bursts this is the third case where the host is found to undergo an episode of intense star formation. This suggests that a fraction of all short-burst progenitors hosted in star-forming galaxies could be physically related to recent star formation activity, implying a relatively short merger time scale.Comment: 6 pages, ApJ, accepted for publicatio

Economic Outlook for Representative Cotton Farms Given the August 2004 FAPRI/AFPC Baseline

The farm level economic impacts of the Farm Security and Rural Investment Act of 2002 on representative cotton farms are projected in this report. The analysis was conducted over the 2001-2008 planning horizon using FLIPSIM, AFPC’s whole farm simulation model. Data to simulate cotton operations in the nation’s major production regions came from two sources: - Producer panel cooperation to develop economic information to describe and simulate representative cotton farms. - Projected prices, policy variables, and input inflation rates from the Food and Agricultural Policy Research Institute (FAPRI) August 2004 Baseline. The primary objective of the analysis is to determine cotton farms’ economic viability by region through the life of the 2002 Farm Bill. The FLIPSIM policy simulation model incorporates the historical price and production risk faced by cotton farmers. This report presents the results of the August 2004 Baseline in a risk context using selected simulated probabilities and ranges for annual net cash farm income values. The probability of a farm experiencing annual cash flow deficits and the probability of a farm losing real net worth are included as indicators of the cash flow and equity risks facing farms through the year 2008. This report is organized into five sections. The first section summarizes the process used to develop the representative farms and the key assumptions utilized for the farm level analysis. The second section summarizes the FAPRI August 2004 Baseline and the policy and price assumptions used for the representative farm analyses. The third section presents the results of the simulation analyses for cotton farms. Two appendices constitute the final sections of the report. Appendix A provides tables to summarize the physical and financial characteristics for each of the representative cotton farms. Appendix B provides the names of producers, land grant faculty, and industry leaders who cooperated in the panel interview process to develop the representative farms.Agribusiness, Agricultural and Food Policy, Crop Production/Industries,

Representative Farms Economic Outlook for the August 2007 FAPRI/AFPC Baseline

The farm level economic impacts of the Farm Security and Rural Investment Act of 2002 on representative crop and livestock operations are projected in this report. The analysis was conducted over the 2005-2012 planning horizon using FLIPSIM, AFPC’s whole farm simulation model. Data to simulate farming operations in the nation’s major production regions came from two sources: • Producer panel cooperation to develop economic information to describe and simulate representative crop, livestock, and dairy farms, and • Projected prices, policy variables, and input inflation rates from the Food and Agricultural Policy Research Institute (FAPRI) August 2007 Baseline. The FLIPSIM policy simulation model incorporates the historical risk faced by farmers for prices and production. This report presents the results of the August 2007 Baseline in a risk context using selected simulated probabilities and ranges for annual net cash farm income values. The probability of a farm experiencing negative ending cash reserves and the probability of a farm losing real net worth are included as indicators of the cash flow and equity risks facing farms through the year 2012.Agribusiness, Agricultural and Food Policy, Crop Production/Industries,

Proteome analysis of Arabidopsis thaliana by two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionisation-time of flight mass spectrometry

In the present study we show results of a large-scale proteome analysis of the recently sequenced plant Arabidopsis thaliana. On the basis of a previously published sequential protein extraction protocol, we prepared protein extracts from eight different A. thaliana tissues (primary leaf, leaf, stem, silique, seedling, seed, root, and inflorescence) and analysed these by two-dimensional gel electrophoresis. A total of 6000 protein spots, from three of these tissues, namely primary leaf, silique and seedling, were excised and the contained proteins were analysed by matrix assisted laser desorption/ionisation time of flight mass spectrometry peptide mass fingerprinting. This resulted in the identification of the proteins contained in 2943 spots, which were found to be products of 663 different genes. In this report we present and discuss the methodological and biological results of our plant proteome analysis

Representative Farms Economic Outlook for the January 2007 FAPRI/AFPC Baseline

The farm level economic impacts of the Farm Security and Rural Investment Act of 2002 on representative crop and livestock operations are projected in this report. The analysis was conducted over the 2005-2012 planning horizon using FLIPSIM, AFPC’s whole farm simulation model. Data to simulate farming operations in the nation’s major production regions came from two sources: • Producer panel cooperation to develop economic information to describe and simulate representative crop, livestock, and dairy farms, and • Projected prices, policy variables, and input inflation rates from the Food and Agricultural Policy Research Institute (FAPRI) January 2007 Baseline. The FLIPSIM policy simulation model incorporates the historical risk faced by farmers for prices and production. This report presents the results of the January 2007 Baseline in a risk context using selected simulated probabilities and ranges for annual net cash farm income values. The probability of a farm experiencing negative ending cash reserves and the probability of a farm losing real net worth are included as indicators of the cash flow and equity risks facing farms through the year 2012.Agribusiness, Crop Production/Industries, Livestock Production/Industries,

Herbal medicines for the treatment of inflammatory bowel disease

© 2014 The Cochrane Collaboration. This is the protocol for a review and there is no abstract. The objectives are as follows: The primary objectives are to assess the efficacy and safety of herbal medicines for the treatment of patients with IBD