4 research outputs found

    Calibration and Evaluation of Blackbeard Time Tagging Capability

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    The Blackbeard instrument is a broadband radio receiver on the ALEXIS (Array of Low Energy X-ray Imaging Sensors) satellite. It detects and records transient VHF radio signals. During November and December of 1996, the Los Alamos Portable Pulser (LAPP) facility was used to transmit 31 broadband pulses to Blackbeard to evaluate the instrument\u27s time tagging accuracy. LAPP firing times were used in conjunction with propagation delays to compute estimated times of arrival (ETOAs) for pulses reaching Blackbeard. ETOAs were compared to Blackbeard reported times of arrival (RTOAs), which were computed using information returned by Blackbeard and an algorithm presented in this paper. For the 31 pulser shots received by Blackbeard, the mean difference between ETOA and RTOA was 1.97 milliseconds, with RTOAs occurring later than ETOAs. The standard deviation of the difference was 0.43 milliseconds. As a result of the study, the algorithm used for accurate Blackbeard time tag studies has been modified to subtract 1.97 milliseconds from reported times of arrival. The 0.43 ms error standard deviation is now used to describe the uncertainty of Blackbeard time tags

    Second asymptomatic carotid surgery trial (ACST-2) : a randomised comparison of carotid artery stenting versus carotid endarterectomy

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    Background: Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or death. Comparison of their long-term protective effects requires large-scale randomised evidence. Methods: ACST-2 is an international multicentre randomised trial of CAS versus CEA among asymptomatic patients with severe stenosis thought to require intervention, interpreted with all other relevant trials. Patients were eligible if they had severe unilateral or bilateral carotid artery stenosis and both doctor and patient agreed that a carotid procedure should be undertaken, but they were substantially uncertain which one to choose. Patients were randomly allocated to CAS or CEA and followed up at 1 month and then annually, for a mean 5 years. Procedural events were those within 30 days of the intervention. Intention-to-treat analyses are provided. Analyses including procedural hazards use tabular methods. Analyses and meta-analyses of non-procedural strokes use Kaplan-Meier and log-rank methods. The trial is registered with the ISRCTN registry, ISRCTN21144362. Findings: Between Jan 15, 2008, and Dec 31, 2020, 3625 patients in 130 centres were randomly allocated, 1811 to CAS and 1814 to CEA, with good compliance, good medical therapy and a mean 5 years of follow-up. Overall, 1% had disabling stroke or death procedurally (15 allocated to CAS and 18 to CEA) and 2% had non-disabling procedural stroke (48 allocated to CAS and 29 to CEA). Kaplan-Meier estimates of 5-year non-procedural stroke were 2·5% in each group for fatal or disabling stroke, and 5·3% with CAS versus 4·5% with CEA for any stroke (rate ratio [RR] 1·16, 95% CI 0·86-1·57; p=0·33). Combining RRs for any non-procedural stroke in all CAS versus CEA trials, the RR was similar in symptomatic and asymptomatic patients (overall RR 1·11, 95% CI 0·91-1·32; p=0·21). Interpretation: Serious complications are similarly uncommon after competent CAS and CEA, and the long-term effects of these two carotid artery procedures on fatal or disabling stroke are comparable
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