Hydrocephalus 2008, 17–20th September, Hannover Germany: a conference report

Hydrocephalus 2008 was held 17–20 September in Hannover, Germany, at the invitation of Petra M Klinge (President), co-hosted by Joachim K. Krauss (Vice President), and Madjid Samii (Honorary President). This meeting was a successor to Hydrocephalus 2006 held in Göteborg, Sweden, organised by Past-President, Carsten Wikkelso. The conference began with a general introductory session of six talks including three invited lectures, followed by eighteen parallel sessions. Subjects covered were hydrocephalus signs, symptoms and diagnosis, especially in normal pressure hydrocephalus; cerebrospinal fluid (CSF) physics and dynamics; CSF function and modelling of function; dementia and quality of life, economy, health care and rehabilitation; neuropsychology, cognition and outcome assessment; neuroimaging, functional imaging and non-invasive diagnostics; paediatric and adolescent hydrocephalus; intelligent shunt and valve design (e.g. telemetry, adjustable and antimicrobial shunts); endoscopic third ventriculostomy; technical advances and image-guided surgical approaches in the treatment of hydrocephalus; brain metabolism, biomarkers and biophysics; co-morbidity, classification and aetiology; epidemiology, registries and clinical trials; experimental hydrocephalus; and pharmaceutical modulation of central nervous system function (CNS drug delivery). Each session began with introductory talks from the invited chairpersons followed by six to eight submitted oral presentations. Overall, 136 oral presentations and 18 posters were presented, the abstracts of which were published elsewhere [1]. We present here an account of the introductory session, the invited chairperson's talks and the concluding remarks by Anthony Marmarou

Therapeutic concentrations of glucagon-like peptide-1 in cerebrospinal fluid following cell-based delivery into the cerebral ventricles of cats

<p>Abstract</p> <p>Background</p> <p>Neuropeptides may have considerable potential in the treatment of acute and chronic neurological diseases. Encapsulated genetically engineered cells have been suggested as a means for sustained local delivery of such peptides to the brain. In our experiments, we studied human mesenchymal stem cells which were transfected to produce glucagon-like peptide-1 (GLP-1).</p> <p>Methods</p> <p>Cells were packed in a water-permeable mesh bag containing 400 polymeric microcapsules, each containing 3000 cells. The mesh bags were either transplanted into the subdural space, into the brain parenchyma or into the cerebral ventricles of the cat brain. Mesh bags were explanted after two weeks, and cell viability, as well as GLP-1 concentration in the cerebrospinal fluid (CSF), was measured.</p> <p>Results</p> <p>Viability of cells did not significantly differ between the three implantation sites. However, CSF concentration of GLP-1 was significantly elevated only after ventricular transplantation with a maximum concentration of 73 pM (binding constant = 70 pM).</p> <p>Conclusions</p> <p>This study showed that ventricular cell-based delivery of soluble factors has the capability to achieve concentrations in the CSF which may become pharmacologically active. Despite the controversy about the pharmacokinetic limitations of ventricular drug delivery, there might be a niche in this for encapsulated cell biodelivery of soluble, highly biologically-effective neuropeptides of low molecular weight like GLP-1.</p

Проект планировки и межевания территории квартала в производственно-деловой зоне г. Томска

Подготовка проекта межевания осуществляется применительно к территории, расположенной в границах элемента планировочной структуры – нежилого квартала, ограниченного проспектом Кирова, улицами Киевская, Усова, Артёма. Границы квартала определены генеральным планом города Томска, а также правилами землепользования и застройки города Томска. Проект межевания квартала подготавливается на основе проекта планировки данной территории в целях установления границ земельных участков и содержит графическую и текстовую части. Основанием для подготовки проекта межевания является постановление администрации Города Томска от 27.03.2017 г. №275-з.The boundary-setting plan is developed to the Tomsk’s non-residental quarter. An element of planning structure has its borders submitted by Kirova avenue, Kievskaya, Usova and Artyoma streets. Borders of quarter are defined by the city master plan and rules of land use and building of the city of Tomsk. The boundary-setting plan of quarter is prepared on the basis of the draft area plan of this territory for the purpose of land parcels borders establishment. The project consists of a graphic part and the text explanation. The basis for preparation of the project is the resolution of city administration of Tomsk

Анализ причин возникновения дефектов в резервуарах в процессе их эксплуатации

Цель работы – проанализировать причины возникновения дефектов и методы их устранения резервуаров вертикальных стальных. В процессе выполнения выпускной квалификационной работы были проведены следующие расчеты: 1) определение геометрических параметров резервуара 2)определение толщины всех поясов стенках резервуара 3)расчет стенки на устойчивость. Основные конструктивные, технологические и технико- эксплуатационные характеристики: выявление дефектных мест, технология и организация выполнения ремонтных работ, подготовительные работы, монтаж резервуара, сварочно-монтажные работы резервуара, эксплуатационные работы .The purpose of work - to analyze the causes of defects and remedies vertical steel tanks. During execution of final qualifying work following calculations were made: 1) determining the geometric parameters of the reservoir 2) determining the thickness of the walls of the reservoir zones 3) the calculation of the stability of the wall. The basic constructive, technological and technical and operational characteristics: the identification of defects, the technology and organization of repair work, the preparatory work, the tank assembly, welding and assembly works of the tank, maintenance work

Hernia fibroblasts lack β-estradiol induced alterations of collagen gene expression

BACKGROUND: Estrogens are reported to increase type I and type III collagen deposition and to regulate Metalloproteinase 2 (MMP-2) expression. These proteins are reported to be dysregulated in incisional hernia formation resulting in a significantly decreased type I to III ratio. We aimed to evaluate the β-estradiol mediated regulation of type I and type III collagen genes as well as MMP-2 gene expression in fibroblasts derived from patients with or without history of recurrent incisional hernia disease. We compared primary fibroblast cultures from male/female subjects without/without incisional hernia disease. RESULTS: Incisional hernia fibroblasts (IHFs) revealed a decreased type I/III collagen mRNA ratio. Whereas fibroblasts from healthy female donors responded to β-estradiol, type I and type III gene transcription is not affected in fibroblasts from males or affected females. Furthermore β-estradiol had no influence on the impaired type I to III collagen ratio in fibroblasts from recurrent hernia patients. CONCLUSION: Our results suggest that β-estradiol does not restore the imbaired balance of type I/III collagen in incisional hernia fibroblasts. Furthermore, the individual was identified as an independent factor for the β-estradiol induced alterations of collagen gene expression. The observation of gender specific β-estradiol-dependent changes of collagen gene expression in vitro is of significance for future studies of cellular response