75 research outputs found
Hydrocephalus 2008, 17β20th September, Hannover Germany: a conference report
Hydrocephalus 2008 was held 17β20 September in Hannover, Germany, at the invitation of Petra M Klinge (President), co-hosted by Joachim K. Krauss (Vice President), and Madjid Samii (Honorary President). This meeting was a successor to Hydrocephalus 2006 held in GΓΆteborg, Sweden, organised by Past-President, Carsten Wikkelso. The conference began with a general introductory session of six talks including three invited lectures, followed by eighteen parallel sessions. Subjects covered were hydrocephalus signs, symptoms and diagnosis, especially in normal pressure hydrocephalus; cerebrospinal fluid (CSF) physics and dynamics; CSF function and modelling of function; dementia and quality of life, economy, health care and rehabilitation; neuropsychology, cognition and outcome assessment; neuroimaging, functional imaging and non-invasive diagnostics; paediatric and adolescent hydrocephalus; intelligent shunt and valve design (e.g. telemetry, adjustable and antimicrobial shunts); endoscopic third ventriculostomy; technical advances and image-guided surgical approaches in the treatment of hydrocephalus; brain metabolism, biomarkers and biophysics; co-morbidity, classification and aetiology; epidemiology, registries and clinical trials; experimental hydrocephalus; and pharmaceutical modulation of central nervous system function (CNS drug delivery). Each session began with introductory talks from the invited chairpersons followed by six to eight submitted oral presentations. Overall, 136 oral presentations and 18 posters were presented, the abstracts of which were published elsewhere [1]. We present here an account of the introductory session, the invited chairperson's talks and the concluding remarks by Anthony Marmarou
Therapeutic concentrations of glucagon-like peptide-1 in cerebrospinal fluid following cell-based delivery into the cerebral ventricles of cats
<p>Abstract</p> <p>Background</p> <p>Neuropeptides may have considerable potential in the treatment of acute and chronic neurological diseases. Encapsulated genetically engineered cells have been suggested as a means for sustained local delivery of such peptides to the brain. In our experiments, we studied human mesenchymal stem cells which were transfected to produce glucagon-like peptide-1 (GLP-1).</p> <p>Methods</p> <p>Cells were packed in a water-permeable mesh bag containing 400 polymeric microcapsules, each containing 3000 cells. The mesh bags were either transplanted into the subdural space, into the brain parenchyma or into the cerebral ventricles of the cat brain. Mesh bags were explanted after two weeks, and cell viability, as well as GLP-1 concentration in the cerebrospinal fluid (CSF), was measured.</p> <p>Results</p> <p>Viability of cells did not significantly differ between the three implantation sites. However, CSF concentration of GLP-1 was significantly elevated only after ventricular transplantation with a maximum concentration of 73 pM (binding constant = 70 pM).</p> <p>Conclusions</p> <p>This study showed that ventricular cell-based delivery of soluble factors has the capability to achieve concentrations in the CSF which may become pharmacologically active. Despite the controversy about the pharmacokinetic limitations of ventricular drug delivery, there might be a niche in this for encapsulated cell biodelivery of soluble, highly biologically-effective neuropeptides of low molecular weight like GLP-1.</p
ΠΡΠΎΠ΅ΠΊΡ ΠΏΠ»Π°Π½ΠΈΡΠΎΠ²ΠΊΠΈ ΠΈ ΠΌΠ΅ΠΆΠ΅Π²Π°Π½ΠΈΡ ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠΈ ΠΊΠ²Π°ΡΡΠ°Π»Π° Π² ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΠΎ-Π΄Π΅Π»ΠΎΠ²ΠΎΠΉ Π·ΠΎΠ½Π΅ Π³. Π’ΠΎΠΌΡΠΊΠ°
ΠΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠ° ΠΏΡΠΎΠ΅ΠΊΡΠ° ΠΌΠ΅ΠΆΠ΅Π²Π°Π½ΠΈΡ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΊ ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠΈ, ΡΠ°ΡΠΏΠΎΠ»ΠΎΠΆΠ΅Π½Π½ΠΎΠΉ Π² Π³ΡΠ°Π½ΠΈΡΠ°Ρ
ΡΠ»Π΅ΠΌΠ΅Π½ΡΠ° ΠΏΠ»Π°Π½ΠΈΡΠΎΠ²ΠΎΡΠ½ΠΎΠΉ ΡΡΡΡΠΊΡΡΡΡ β Π½Π΅ΠΆΠΈΠ»ΠΎΠ³ΠΎ ΠΊΠ²Π°ΡΡΠ°Π»Π°, ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠΏΠ΅ΠΊΡΠΎΠΌ ΠΠΈΡΠΎΠ²Π°, ΡΠ»ΠΈΡΠ°ΠΌΠΈ ΠΠΈΠ΅Π²ΡΠΊΠ°Ρ, Π£ΡΠΎΠ²Π°, ΠΡΡΡΠΌΠ°. ΠΡΠ°Π½ΠΈΡΡ ΠΊΠ²Π°ΡΡΠ°Π»Π° ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½Ρ Π³Π΅Π½Π΅ΡΠ°Π»ΡΠ½ΡΠΌ ΠΏΠ»Π°Π½ΠΎΠΌ Π³ΠΎΡΠΎΠ΄Π° Π’ΠΎΠΌΡΠΊΠ°, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠ°Π²ΠΈΠ»Π°ΠΌΠΈ Π·Π΅ΠΌΠ»Π΅ΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΈ Π·Π°ΡΡΡΠΎΠΉΠΊΠΈ Π³ΠΎΡΠΎΠ΄Π° Π’ΠΎΠΌΡΠΊΠ°. ΠΡΠΎΠ΅ΠΊΡ ΠΌΠ΅ΠΆΠ΅Π²Π°Π½ΠΈΡ ΠΊΠ²Π°ΡΡΠ°Π»Π° ΠΏΠΎΠ΄Π³ΠΎΡΠ°Π²Π»ΠΈΠ²Π°Π΅ΡΡΡ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΡΠΎΠ΅ΠΊΡΠ° ΠΏΠ»Π°Π½ΠΈΡΠΎΠ²ΠΊΠΈ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠΈ Π² ΡΠ΅Π»ΡΡ
ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ Π³ΡΠ°Π½ΠΈΡ Π·Π΅ΠΌΠ΅Π»ΡΠ½ΡΡ
ΡΡΠ°ΡΡΠΊΠΎΠ² ΠΈ ΡΠΎΠ΄Π΅ΡΠΆΠΈΡ Π³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΡΡ ΠΈ ΡΠ΅ΠΊΡΡΠΎΠ²ΡΡ ΡΠ°ΡΡΠΈ. ΠΡΠ½ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π΄Π»Ρ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΏΡΠΎΠ΅ΠΊΡΠ° ΠΌΠ΅ΠΆΠ΅Π²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠΎΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ Π°Π΄ΠΌΠΈΠ½ΠΈΡΡΡΠ°ΡΠΈΠΈ ΠΠΎΡΠΎΠ΄Π° Π’ΠΎΠΌΡΠΊΠ° ΠΎΡ 27.03.2017 Π³. β275-Π·.The boundary-setting plan is developed to the Tomskβs non-residental quarter. An element of planning structure has its borders submitted by Kirova avenue, Kievskaya, Usova and Artyoma streets. Borders of quarter are defined by the city master plan and rules of land use and building of the city of Tomsk. The boundary-setting plan of quarter is prepared on the basis of the draft area plan of this territory for the purpose of land parcels borders establishment. The project consists of a graphic part and the text explanation. The basis for preparation of the project is the resolution of city administration of Tomsk
Microglial downregulation in a double transgenic mouse model associated with early-onset Alzheimer's disease (AD) after intraventricular implantation of alginate encapsulated Glukagon-like-peptide-1 (GLP-1) producing human mesenchymal stem-cells
ΠΠ½Π°Π»ΠΈΠ· ΠΏΡΠΈΡΠΈΠ½ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ² Π² ΡΠ΅Π·Π΅ΡΠ²ΡΠ°ΡΠ°Ρ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΈΡ ΡΠΊΡΠΏΠ»ΡΠ°ΡΠ°ΡΠΈΠΈ
Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΠΏΡΠΈΡΠΈΠ½Ρ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ² ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ ΠΈΡ
ΡΡΡΡΠ°Π½Π΅Π½ΠΈΡ ΡΠ΅Π·Π΅ΡΠ²ΡΠ°ΡΠΎΠ² Π²Π΅ΡΡΠΈΠΊΠ°Π»ΡΠ½ΡΡ
ΡΡΠ°Π»ΡΠ½ΡΡ
. Π ΠΏΡΠΎΡΠ΅ΡΡΠ΅ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ Π²ΡΠΏΡΡΠΊΠ½ΠΎΠΉ ΠΊΠ²Π°Π»ΠΈΡΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΡ Π±ΡΠ»ΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Ρ ΡΠ»Π΅Π΄ΡΡΡΠΈΠ΅ ΡΠ°ΡΡΠ΅ΡΡ: 1) ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π³Π΅ΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΡΠ΅Π·Π΅ΡΠ²ΡΠ°ΡΠ° 2)ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠΎΠ»ΡΠΈΠ½Ρ Π²ΡΠ΅Ρ
ΠΏΠΎΡΡΠΎΠ² ΡΡΠ΅Π½ΠΊΠ°Ρ
ΡΠ΅Π·Π΅ΡΠ²ΡΠ°ΡΠ° 3)ΡΠ°ΡΡΠ΅Ρ ΡΡΠ΅Π½ΠΊΠΈ Π½Π° ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΡ. ΠΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠ²Π½ΡΠ΅, ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ ΡΠ΅Ρ
Π½ΠΈΠΊΠΎ- ΡΠΊΡΠΏΠ»ΡΠ°ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ: Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ Π΄Π΅ΡΠ΅ΠΊΡΠ½ΡΡ
ΠΌΠ΅ΡΡ, ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡ ΠΈ ΠΎΡΠ³Π°Π½ΠΈΠ·Π°ΡΠΈΡ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ ΡΠ΅ΠΌΠΎΠ½ΡΠ½ΡΡ
ΡΠ°Π±ΠΎΡ, ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΡΠ°Π±ΠΎΡΡ, ΠΌΠΎΠ½ΡΠ°ΠΆ ΡΠ΅Π·Π΅ΡΠ²ΡΠ°ΡΠ°, ΡΠ²Π°ΡΠΎΡΠ½ΠΎ-ΠΌΠΎΠ½ΡΠ°ΠΆΠ½ΡΠ΅ ΡΠ°Π±ΠΎΡΡ ΡΠ΅Π·Π΅ΡΠ²ΡΠ°ΡΠ°, ΡΠΊΡΠΏΠ»ΡΠ°ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ°Π±ΠΎΡΡ .The purpose of work - to analyze the causes of defects and remedies vertical steel tanks.
During execution of final qualifying work following calculations were made: 1) determining the geometric parameters of the reservoir 2) determining the thickness of the walls of the reservoir zones 3) the calculation of the stability of the wall. The basic constructive, technological and technical and operational characteristics: the identification of defects, the technology and organization of repair work, the preparatory work, the tank assembly, welding and assembly works of the tank, maintenance work
Hernia fibroblasts lack Ξ²-estradiol induced alterations of collagen gene expression
BACKGROUND: Estrogens are reported to increase type I and type III collagen deposition and to regulate Metalloproteinase 2 (MMP-2) expression. These proteins are reported to be dysregulated in incisional hernia formation resulting in a significantly decreased type I to III ratio. We aimed to evaluate the Ξ²-estradiol mediated regulation of type I and type III collagen genes as well as MMP-2 gene expression in fibroblasts derived from patients with or without history of recurrent incisional hernia disease. We compared primary fibroblast cultures from male/female subjects without/without incisional hernia disease. RESULTS: Incisional hernia fibroblasts (IHFs) revealed a decreased type I/III collagen mRNA ratio. Whereas fibroblasts from healthy female donors responded to Ξ²-estradiol, type I and type III gene transcription is not affected in fibroblasts from males or affected females. Furthermore Ξ²-estradiol had no influence on the impaired type I to III collagen ratio in fibroblasts from recurrent hernia patients. CONCLUSION: Our results suggest that Ξ²-estradiol does not restore the imbaired balance of type I/III collagen in incisional hernia fibroblasts. Furthermore, the individual was identified as an independent factor for the Ξ²-estradiol induced alterations of collagen gene expression. The observation of gender specific Ξ²-estradiol-dependent changes of collagen gene expression in vitro is of significance for future studies of cellular response
Periventricular destabilization and ventriculomegaly in aging rats: implications for reduced neurogenesis and cognition
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