Discovery of a large and bright bow shock nebula associated with low mass X-ray binary SAX J1712.6-3739

In a multiwavelength program dedicated to identifying optical counterparts of faint persistent X-ray sources in the Galactic Bulge, we find an accurate X-ray position of SAX J1712.6-3739 through Chandra observations, and discover its faint optical counterpart using our data from EFOSC2 on the ESO 3.6m telescope. We find this source to be a highly extincted neutron star LMXB with blue optical colours. We serendipitously discover a relatively bright and large bow shock shaped nebula in our deep narrowband H alpha imaging, most likely associated with the X-ray binary. A nebula like this has never been observed before in association with a LMXB, and as such provides a unique laboratory to study the energetics of accretion and jets. We put forward different models to explain the possible ways the LMXB may form this nebulosity, and outline how they can be confirmed observationally.Comment: Accepted for publication in MNRAS-Letters; 5 pages, 4 figures, 2 tables. Quality of figure 2 downgraded because of arXiv file size limit

Agent-based performance assessment tool for general aviation operations under free flight

The objective of this research is to design and demonstrate an agent-based modeling and analysis tool for evaluating General Aviation (GA) pilot situation awareness under free flight air traffic management (ATM). A computational tool is developed to assess free flight's potential effect on GA operators, by combining an agent-based representation of the overall pilot/vehicle/ATM system with quantitative modelbased metrics of pilot SA. The model's performance is demonstrated in a set of simulation trials designed to measure the pilot agent's ability to recognize and correctly assess protected zone conflicts in free flight ATM, using information available from a hypothetical cockpit display of traffic information. A set of simulations is presented to examine the effect of sensor accuracy and attention allocation on pilot awareness of protected zone conflict hazards posed by intruder aircraft. The results show that reducing sensor accuracy leads to an increase in overall SA error, and that the pilot agent divides its attention over multiple traffic hazards in proportion to each intruder's hazard potential. This attention-sharing varies dynamically as the conflict situation changes, in a manner that is consistent with intuitive expectations

Exploring Accretion and Disk-Jet Connections in the LLAGN M81*

We report on a year-long effort to monitor the central supermassive black hole in M81 in the X-ray and radio bands. Using Chandra and the VLA, we obtained quasi-simultaneous observations of M81* on seven occasions during 2006. The X-ray and radio luminosity of M81* are not strongly correlated on the approximately 20-day sampling timescale of our observations, which is commensurate with viscous timescales in the inner flow and orbital timecales in a radially-truncated disk. This suggests that short-term variations in black hole activity may not be rigidly governed by the "fundamental plane", but rather adhere to the plane in a time-averaged sense. Fits to the X-ray spectra of M81* with bremsstrahlung models give temperatures that are inconsistent with the outer regions of very simple advection-dominated inflows. However, our results are consistent with the X-ray emission originating in a transition region where a truncated disk and advective flow may overlap. We discuss our results in the context of models for black holes accreting at small fractions of their Eddington limit, and the fundamental plane of black hole accretion.Comment: Accepted for publication in Ap

Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs

The extracellular lysophospholipase D autotaxin (ATX) and its product, lysophosphatidic acid, have diverse functions in development and cancer, but little is known about their functions in the immune system. Here we found that ATX had high expression in the high endothelial venules of lymphoid organs and was secreted. Chemokine-activated lymphocytes expressed receptors with enhanced affinity for ATX, which provides a mechanism for targeting the secreted ATX to lymphocytes undergoing recruitment. Lysophosphatidic acid induced chemokinesis in T cells. Intravenous injection of enzymatically inactive ATX attenuated the homing of T cells to lymphoid tissues, probably through competition with endogenous ATX and exertion of a dominant negative effect. Our results support the idea of a new and general step in the homing cascade in which the ectoenzyme ATX facilitates the entry of lymphocytes into lymphoid organs

The balance of power: accretion and feedback in stellar mass black holes

In this review we discuss the population of stellar-mass black holes in our galaxy and beyond, which are the extreme endpoints of massive star evolution. In particular we focus on how we can attempt to balance the available accretion energy with feedback to the environment via radiation, jets and winds, considering also possible contributions to the energy balance from black hole spin and advection. We review quantitatively the methods which are used to estimate these quantities, regardless of the details of the astrophysics close to the black hole. Once these methods have been outlined, we work through an outburst of a black hole X-ray binary system, estimating the flow of mass and energy through the different accretion rates and states. While we focus on feedback from stellar mass black holes in X-ray binary systems, we also consider the applicability of what we have learned to supermassive black holes in active galactic nuclei. As an important control sample we also review the coupling between accretion and feedback in neutron stars, and show that it is very similar to that observed in black holes, which strongly constrains how much of the astrophysics of feedback can be unique to black holes.Comment: To be published in Haardt et al. Astrophysical Black Holes. Lecture Notes in Physics. Springer 201

ALMA observations of 4U 1728 - 34 and 4U 1820 - 30: First detection of neutron star X-ray binaries at 300 GHz

We report on the first observations of neutron star low-mass X-ray binaries with the Atacama Large Millimeter/submillimeter Array (ALMA) at ~300 GHz. Quasi-simultaneous observations of 4U 1728-34 and 4U 1820-30 were performed at radio (ATCA), infrared (VLT) and X-ray (Swift) frequencies, spanning more than eight decades in frequency coverage. Both sources are detected at high significance with ALMA. The spectral energy distribution of 4U 1728-34 is consistent with synchrotron emission from a jet with a break from optically thick to optically thin emission at 1.3-11.0 × 1013 Hz. This is the third time a jet spectral break has been reported for a neutron star X-ray binary. The radio to mm spectral energy distribution of 4U 1820-30 has significant detections at 5 and 300 GHz. This confirms the presence of radio emission during a soft state for this neutron star and represents the first detection of mm emission during such a state, unambiguously pointing to the presence of a jet. We also report on three additional unrelated sources - showing mm emission - in the ALMA fields of view of 4U 1728-34 and 4U 1820-30. © ESO, 2017

Strong CH+ J=1-0 emission and absorption in DR21

We report the first detection of the ground-state rotational transition of the methylidyne cation CH+ towards the massive star-forming region DR21 with the HIFI instrument onboard the Herschel satellite. The line profile exhibits a broad emission line, in addition to two deep and broad absorption features associated with the DR21 molecular ridge and foreground gas. These observations allow us to determine a CH+ J=1-0 line frequency of 835137 +/- 3 MHz, in good agreement with a recent experimental determination. We estimate the CH+ column density to be a few 1e13 cm^-2 in the gas seen in emission, and > 1e14 cm^-2 in the components responsible for the absorption, which is indicative of a high line of sight average abundance [CH+]/[H] > 1.2x10^-8. We show that the CH+ column densities agree well with the predictions of state-of-the-art C-shock models in dense UV-illuminated gas for the emission line, and with those of turbulent dissipation models in diffuse gas for the absorption lines.Comment: Accepted for publication in A&

Investigating the disc-jet coupling in accreting compact objects using the black hole candidate Swift J1753.5-0127

In studies of accreting black holes in binary systems, empirical relations have been proposed to quantify the coupling between accretion processes and ejection mechanisms. These processes are probed respectively by means of X-ray and radio/optical-infrared observations. The relations predict, given certain accretion conditions, the expected energy output in the form of a jet. We investigated this coupling by studying the black hole candidate Swift J1753.5-0127, via multiwavelength coordinated observations over a period of ~4 years. We present the results of our campaign showing that, all along the outburst, the source features a jet that is fainter than expected from the empirical correlation between the radio and the X-ray luminosities in hard spectral state. Because the jet is so weak in this system the near-infrared emission is, unusually for this state and luminosity, dominated by thermal emission from the accretion disc. We briefly discuss the importance and the implications of a precise determination of both the slope and the normalisation of the correlations, listing some possible parameters that broadband jet models should take into account to explain the population of sources characterized by a dim jet. We also investigate whether our data can give any hint about the nature of the compact object in the system, since its mass has not been dynamically measured.Comment: Accepted for publication in MNRA

CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity

During CNS autoimmunity, brain endothelial cell CXCR7 internalizes CXCL12 from the perivascular space, thereby permitting leukocyte migration into the CNS parenchyma

The serotonin transporter linked polymorphic region and brain-derived neurotrophic factor valine to methionine at position 66 polymorphisms and maternal history of depression: Associations with cognitive vulnerability to depression in childhood

Preliminary work indicates that cognitive vulnerability to depression may be associated with variants of the serotonin transporter promoter polymorphism (5-HTTLPR) and the valine to methionine at position 66 (val66met) polymorphism of the brain-derived neurotrophic factor (BDNF) gene; however, existing reports come from small samples. The present study sought to replicate and extend this research in a sample of 375 community-dwelling children and their parents. Following a negative mood induction, children completed a self-referent encoding task tapping memory for positive and negative self-descriptive traits. Consistent with previous work, we found that children with at least one short variant of the 5-HTTLPR had enhanced memory for negative self-descriptive traits. The BDNF val66met polymorphism had no main effect but was moderated by maternal depression, such that children with a BDNF methionine allele had a heightened memory for negative self-descriptive traits when mothers had experienced depression during children\u27s lifetimes; in contrast, children with a methionine allele had low recall of negative traits when mothers had no depression history. The findings provide further support for the notion that the 5-HTTLPR is associated with cognitive markers of depression vulnerability and that the BDNF methionine allele moderates children\u27s sensitivity to contextual factors. Copyright © Cambridge University Press 2013