Observer perceptions of the justifiability of the actions of nations in conflict: The relative importance of conveying national vulnerability versus strength

Because the underdog in a conflict typically gains the support of observers, nations will often adopt a narrative that persuades both their domestic following and international allies that they are the true victim in the conflict. Three survey studies were conducted to assess the perceptions of citizens of a third-party observer nation (Canada) in relation to two nations in conflict that differ in their historical persecution, namely the U.S. and Israel. Perceptions of the vulnerability of their safety and survival, and their strength to protect themselves against their opponents were hypothesized to mediate differences in the perceived justification for each nation's conflict actions. Study 1 (N = 91) supported this mediational model, with the U.S. seen as less vulnerable and more powerful than Israel, and perceptions of vulnerability accounting for differences in the justifiability of their respective conflict actions. Study 2 (N = 315) further demonstrated a moderating effect of Canadians' shared identity with the nations

Probing for Membrane Domains in the Endoplasmic Reticulum: Retention and Degradation of Unassembled MHC Class I Molecules

Quality control of protein biosynthesis requires ER-retention and ER-associated degradation (ERAD) of unassembled/misfolded molecules. Although some evidence exists for the organization of the ER into functionally distinct membrane domains, it is unknown if such domains are involved in the retention and ERAD of unassembled proteins. Here, it is shown that unassembled MHC class I molecules are retained in the ER without accumulating at ER-exit sites or in the ERGIC of β2m(−/−) cells. Furthermore, these molecules did not cluster in the ER membrane and appeared to be highly mobile even when ERAD or their association with calnexin were inhibited. However, upon ATP depletion, they were reversibly segregated into an ER membrane domain, distinct from ER exit sites, which included calnexin and COPII, but not the ERGIC marker protein p58. This quality control domain was also observed upon prolonged inhibition of proteasomes. Microtubules were required for its appearance. Segregation of unfolded proteins, ER-resident chaperones, and COPII may be a temporal adaptation to cell stress