Exploring Potential Impact of AI on Social Work Practice

This assignment is designed to help students identify, understand and critically analyze the advantages and disadvantages Artificial Intelligence may have on the future of social work practice

Graduate Recital:Loretta Jane Kitko, Viola

Kemp Recital Hall Sunday Evening April 6, 2003 7:00p.m

Axatilimab for chronic graft-versus-host disease after failure of at least two prior systemic therapies: Results of a phase I/II study

PURPOSE: Chronic graft-versus-host disease (cGVHD) remains the major cause of late morbidity after allogeneic hematopoietic cell transplantation. Colony-stimulating factor 1 receptor (CSF-1R)-dependent macrophages promote cGVHD fibrosis, and their elimination in preclinical studies ameliorated cGVHD. Axatilimab is a humanized monoclonal antibody that inhibits CSF-1R signaling and restrains macrophage development. PATIENTS AND METHODS: This phase I (phI)/phase II (phII) open-label study (ClinicalTrials.gov identifier: NCT03604692) evaluated safety, tolerability, and efficacy of axatilimab in patients age ≥ 6 years with active cGVHD after ≥ 2 prior systemic therapy lines. Primary objectives in phI were to identify the optimal biologic and recommended phII dose and in phII to evaluate the overall (complete and partial) response rate (ORR) at the start of treatment cycle 7. RESULTS: Forty enrolled patients (17 phI; 23 phII) received at least one axatilimab dose. In phI, a dose of 3 mg/kg given once every 4 weeks met the optimal biologic dose definition. Two dose-limiting toxicities occurred at the 3 mg/kg dose given once every 2 weeks. At least one treatment-related adverse event (TRAE) was observed in 30 patients with grade ≥ 3 TRAEs in eight patients, the majority known on-target effects of CSF-1R inhibition. No cytomegalovirus reactivations occurred. With the 50% ORR at cycle 7 day 1, the phII cohort met the primary efficacy end point. Furthermore, the ORR in the first six cycles, an end point supporting regulatory approvals, was 82%. Responses were seen in all affected organs regardless of prior therapy. Fifty-eight percent of patients reported significant improvement in cGVHD-related symptoms using the Lee Symptom Scale. On-target activity of axatilimab was suggested by the decrease in skin CSF-1R-expressing macrophages. CONCLUSION: Targeting profibrotic macrophages with axatilimab is a therapeutically promising novel strategy with a favorable safety profile for refractory cGVHD

Achieving medical stability: Wives\u27 experiences with heart failure

The incidence of heart failure continues to rise as innovative treatments are developed. Despite life-prolonging interventions, morbidity and mortality in patients younger than 65 remain high. Few studies have focused on this younger cohort and/or their family caregivers as they navigate the complex illness trajectories manifested in heart failure. Instrumental case studies were employed to present exemplars for each of the five identified heart failure trajectories. Culling data from a longitudinal study of female spousal caregivers, each case study represents a wife\u27s discussion of caring for a husband (years) in response to the husband\u27s changing heart failure trajectory. The goal of medical stability and the notion of uncertainty permeate throughout the case studies. Suggestions for supporting these wives are presented. © The Author(s) 2010

Designing a Recycling Facility for Energy Materials

The purpose of this design project is to create a recycling facility for energy materials. Different energy systems will be analyzed to determine the most economically appropriate energy material to recycle. A list of the energy systems to be analyzed includes catalyst converters, wind turbines, lithium ion batteries, photo-voltaic cells, and precious materials with high energy applications. This study involves two main parts: the research to determine the most appropriate energy material for recycling, while also choosing or creating recycling processes efficient enough to reduce the US’s reliance on foreign nations for obtaining their rare-earth materials. The second part is the design of the facility and determining a combination of machines and processes to be used. An economic analysis of the energy material and facility will be completed. The objective for this study was partially stated. The US relies heavily on multiple nations for the mining and importing of rare-earth, high energy, application materials. There is also little infrastructure currently for recycling or reusing these materials. Constantly purchasing these materials places a large financial burden on the US. Most importantly, throwing away these used materials is extremely harmful to our environment and needs to be reduced

Successful unrelated donor cord blood transplantation for Glanzmann’s thrombasthenia

GT, a rare disorder of platelet function, can lead to life-threatening bleeding, particularly following the development of antiplatelet antibodies. Curative therapy includes HCT but previous reports are limited predominantly to matched siblings and have excluded CBT. Delayed or non-engraftment of platelets because of antiplatelet antibodies might be particularly concerning after CBT for GT. Here, we report two successful unrelated cord blood transplants for GT. Recurrent life-threatening bleeding was the primary indication for HCT, with one patient developing antiplatelet antibodies pre-HCT. Bleeding risks associated with delivery of the conditioning regimen and the toxicity that follows should be carefully considered, including tunneled central venous line catheter placement, inclusion of B cell-specific therapy to potentially decrease antiplatelet antibody production, and targeted busulfan dosing. This is the first report of successful unrelated cord blood HCT for GT and indicates that modifications to supportive care can improve the safety of this potentially curative therapy for patients with severe, life-threatening disease manifestations.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/78580/1/j.1399-3046.2009.01251.x.pd

The Role of the Corneocyte Lipid Envelopes in Cohesion of the Stratum Corneum

Treatment of isolated stratum corneum with certain detergents results in complete disaggregation of the corneocytes within hours at 45°C without agitation. This is prevented by prior heating of the tissue to 80° C or by solvent extraction of the intercellular lipids. In the present study, electron micros- copy revealed that the heated or solvent-extracted tissue was characterized by cell-to-cell contacts that appeared to involve the chemically bound hydroxyceramides which constitute the corneocyte lipid envelope. It is proposed that the irreversible bonding between corneocytes that results from heating or lipid extraction results from interdigitation of the sphingosine chains belonging to those hydroxyceramides that are bound to the corneocyte protein envelope by the ω-hydroxyl function of the 30- and 32-carbon hydroxyacid moieties. Similar interdigitaion of adjacent envelopes might be involved in natural stratum corneum cohesion, limited mostly to the periphery of corneocytes where the absence of inter-cellular lamellae allows the appropriate cell-to-cell contact