18 research outputs found
Integrally Geared Compressors
Discussion GroupHow to specify an integrally geared compressor
Typical process applications
Controlling an integral gear compressor - IGV, VFD
Rotordynamic consideration
Screw Compressors
Discussion GroupAPI Standard 619 for screw compressors
Wet and dry
Silencers for dry screw compressors
Noise reduction methods
Lubricants and lubricant carryover for flooded screw compressor
Over-compression and under-compression
Pulsation and vibration issue
Pharmacogenetics: CYPs, NAT2 and 5-HTT Related to Antidepressants
Pharmacogenetics (PGt), the study of a gene\u27s influence on patient response to a drug, shows strong potential for explaining issues with efficacy related to antidepressant medications. Each year, antidepressants are one of the most commonly prescribed medications due to the millions of Americans affected by depression. Importantly, it is recognized that there is wide interpatient variability in drug response to antidepressants caused by genetic mutations, which can alter the pharmacodynamic (PD) and pharmacokinetic (PK) properties of various drugs used to treat depression. Proteins that are mainly involved in how patients respond to medications include receptors, drug-targeted proteins, drug transport proteins and drug-metabolizing enzymes. Specifically in depression, variations in the serotonin reuptake transporter (SERT-1 or 5-HTT), N-acetyltransferase (NAT2), cytochrome P450 (CYP) 2C19, 2D6, and 1A2 can affect the outcomes of patients receiving certain antidepressant medications. Utilizing PGt can help prevent the trial and error in prescribing antidepressants and lead to better patient outcomes in the treatment of depression. Pharmacists can utilize genetic information to help primary care physicians choose drug regimens that are more likely to benefit their patients. Although advances are being made in this subject matter, some major efforts of future research will evaluate the efficacy of drug regimens and the dosing of drugs based on patient genetics
Integrally Geared Compressors
Discussion GroupHow to specify an integrally geared compressor
Typical process applications
Controlling an integral gear compressor - IGV, VFD
Rotordynamic consideration