The burden of pediatric atopic dermatitis: quality of life of patients and their families

(1) Background: Atopic dermatitis (AD) is one of the most common inflammatory skin conditions, thus having a significant impact on the quality of life (QoL) of patients and their families. We performed a survey to gather more data to help describe the burden of AD in Lithuania and to help expand the treatment plan to this important aspect of the disease. (2) Methods: A cross-sectional study was conducted involving healthy and AD pediatric patients. The assessment instruments used were the Patient-Oriented Eczema Measure (POEM), QoL, and original questionnaires (the original questionnaire was designed by the authors to determine the demographics, medical history, and treatment methods of the respondents). (3) Results: This study included 302 participants in total: 247 AD patients (51% boys) and 55 non-AD patients (51% boys). The mean age for AD patients was 6.8 ± 4.4. years, and this was 10.5 ± 3.1 years for the control patients. A significant difference was found between the QoL questionnaire scores and the Family Dermatology Life Quality Index (FDLQI) score for the atopic dermatitis group (QoL: 6.3 ± 5.6; FDLQI: 7.1 ± 6.9) and controls (QoL 0.5 ± 1.1; FDLQI 2.1 ± 5.9) (p = 0.000). The mean QoL questionnaire score for severe AD was 14.3 ± 6.2 (very large effect), that for moderate AD was 6.9 ± 4.4 (moderate effect), and that for mild AD was 4.4 ± 4.2 (small effect) (p = 0.000). (4) Conclusions: Our study revealed a moderate effect of AD on dermatology-related QoL in patients and their families. It has been shown that increased disease severity was associated with a greater impairment of QoL in both patients and patient’s parents. The burden of AD in children and their parents is considerable and should be taken into account in the management of atopic dermatitis

Vegetation responses to climatic changes during the late glacial according to palaeobotanical data in western Lithuania : a preliminary results

The organic-rich material has been studied from the bottom part of lacustrine sediments of the Lake Kasuciai, western Lithuania. Radiocarbon dates and palaeobotanical data showed that these sediments accumulated between 13,500 and 9000 14C yr BP. The Late Glacial interstadial is defined by the dominance of Characeae and accumulation of carbonate. The Bolling is characterized by the pioneer taxa and the communities of open habitats. During the Allerod pine replaced the light demanding taxa that show development of a closer woodland habitat and dryness of climate. The short period between Bolling and Allerod with increasing representation of Betula and plants typical for the highly eroded habitats could be correlated with Older Dryas. The onset of the Younger Dryas is marked by degradation of the forest cover and expansion of heliophytic grasses. Entire vegetation cover with birch and pine forest was settled during the Preborial. Formation of calcareous sediments and appearance of thermophilous taxa confirm the climatic amelioration

Post-glacial vegetation and environment of the Labanoras Region, East Lithuania: implications for regional history

Multiproxy data (pollen, plant macrofossils, 14C dates and loss-on--ignition measurements) obtained from the Bevardis and Verpstinis lakes in the Labanoras area (East Lithuania) were used to reconstruct a vegetation history and to reveal major environmental features during post-glacial time. Biostratigraphical data indicates ongoing sedimentation in Verpstinis Lake since the final stages of the AllerÝd. The pollen data shows that Pinus-dominated forest flourished during the AllerÝd, while the Younger Dryas was characterized by open shrub/herb/grass vegetation with highly abundant Juniperus. These are evidences of severe climatic conditions in the area. The 14C data suggests that sedimentation started in Bevardis Lake with the onset of the Holocene. Picea immigrated into the Verpstinis Lake surroundings in the Late Glacial, just before 11 500 cal yr BP according to the palynological evidence. The expanding deciduous taxa, e.g., Corylus (ca. 10 200-10 000 cal yr BP), Alnus (8200-8000 cal yr BP), and broad-leaved species with Ulmus (ca. 10 000 cal yr BP), Tilia (7700-7400 cal yr BP) and Quercus (5200 cal yr BP), formed a dense mixed forest where Picea appeared at 7300-6800 cal yr BP. Both diagrams show only negligible human impact. It seems that natural factors were responsible for the formation of vegetation cover and environment in the study area throughout the post-glacial

Associations between Atopic Dermatitis and Behavior Difficulties in Children

Background and Objectives: There has been increasing evidence that atopic dermatitis (AD) is associated with behavioral difficulties (BDs). There is currently a lack of evidence of how the severity of the disease determines BDs and what additional factors may contribute to their manifestation. The aim is to determine what kind of BDs occur in children with AD compared to healthy children and to find out what additional factors may contribute to the development of BDs in AD patients. Materials and Methods: This is a cross-sectional, prospective study with the application of a risk assessment instrument for behavior difficulties (Child Behavior Checklist, CBCL 6/18) in pediatric patients with AD and healthy controls (6–17 years) between 1 January 2020 and 31 December 2022. For statistical comparison, mainly Wilcoxon–Mann–Whitney and Student’s t-test were used, considering a significance level of 5%. Results: This study included a total of 101 children: 48% with AD, 52% non-AD. The mean age was 10 ± 2.7 years for AD, and10.5 ± 3.1 years for the control patients. AD patients had higher internal behavior scale scores and T-scores (6.6 ± 6.4 vs. 9.6 ± 6.9 and 47.9 ± 9.5 vs. 52.3 ± 10.2, p = 0.01), anxiety/depression scale score and T-score (2.8 ± 2.7 vs. 4.3 ± 3.5 and 47.7 ± 8.4 vs. 52.5 ± 11, p = 0.02), and somatic problems scale score and T-score (2.1 ± 2.3 vs. 3.5 ± 3 and 47.6 ± 8.5 vs. 52.7 ± 10.9, p = 0.005). Patients with severe AD had sleep disturbance and itching scores higher than those with mild–moderate AD (5.4 ± 2.6 vs. 2.4 ± 2.2, p = 0.000 and 6.6 ± 2.4 vs. 4 ± 2.8, p = 0.001). The mean morning serum cortisol concentration was lower in AD patients compared to controls (252.91 ± 304.34 vs. 351.55 ± 126.09 nmol/L, p = 0.047). Conclusions: Children with AD present a higher risk of BDs than healthy controls. Patients with severe AD experience more sleep disturbances and a greater intensity of itching compared to mild–moderate AD. The occurrence of BDs was not related to serum cortisol levels. The cortisol level, severity, age, gender, duration of illness, intensity of pruritus, and sleep disturbance did not affect the development of BDs