Prevalence of polymorphisms of the genes responsible for auto-inflammatory diseases among 202 patients with recurrent fever in a rheumatology institute in Japan

Pediatric Rheumatology Congress 2014 2014年09月20日 SERBI

Prevalence of polymorphisms of the genes responsible for auto-inflammatory diseases among 202 patients with recurrent fever in a rheumatology institute in Japan

Pediatric Rheumatology Congress 2014 2014年09月20日 SERBI

肯定についての試論

AbstractThis paper first deals with the meaning of "saying Yes". It also asks if the things to which we say"Yes" are "good" (and if "saying Yes" is "good"). As a result, the meaning of "saying Yes to ourlife" or "saying Yes to the reality in the world" becomes clearer. The result shows how difficultsuch a "Yes" is, and finally it explores how we can realize it

A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias

Free Fatty Acid Receptor 2 is a GPCR activated by short chain fatty acids produced in high levels in the lower gut by microbial fermentation of non-digestible carbohydrates. A major challenge in studying this receptor is that the mouse ortholog does not have significant affinity for antagonists that are able to block the human receptor. Docking of exemplar antagonists from two chemical series to homology models of both human and mouse Free Fatty Acid Receptor 2 suggested that a single lysine - arginine variation at the extracellular face of the receptor might provide the basis for antagonist selectivity and mutational swap studies confirmed this hypothesis. Extending these studies to agonist function indicated that although the lysine - arginine variation between human and mouse orthologs had limited effect on G protein-mediated signal transduction, removal of positive charge from this residue produced a signalling-biased variant of Free Fatty Acid Receptor 2 in which Gi-mediated signalling by both short chain fatty acids and synthetic agonists was maintained whilst there was marked loss of agonist potency for signalling via Gq/11 and G12/13 G proteins. A single residue at the extracellular face of the receptor thus plays key roles in both agonist and antagonist function

Characteristics of infants born to mothers with autoimmune disorders

POSTER PRESENTATION21st European Pediatric Rheumatology (PReS) Congress / 17-21 September 2014 / Belgrade, Serbi