Effective Action for High-Energy Scattering in Gravity

The multi-Regge effective action is derived directly from the linearized gravity action. After excluding the redundant field components we separate the fields into momentum modes and integrate over modes which correspond neither to the kinematics of scattering nor to the one of exchanged particles. The effective vertices of scattering and of particle production are obtained as sums of the contributions from the triple and quartic interaction terms and the fields in the effective action are defined in terms of the two physical components of the metric fluctuation.Comment: 15 pages, LATE

An inquiry-based learning approach to teaching information retrieval

The study of information retrieval (IR) has increased in interest and importance with the explosive growth of online information in recent years. Learning about IR within formal courses of study enables users of search engines to use them more knowledgeably and effectively, while providing the starting point for the explorations of new researchers into novel search technologies. Although IR can be taught in a traditional manner of formal classroom instruction with students being led through the details of the subject and expected to reproduce this in assessment, the nature of IR as a topic makes it an ideal subject for inquiry-based learning approaches to teaching. In an inquiry-based learning approach students are introduced to the principles of a subject and then encouraged to develop their understanding by solving structured or open problems. Working through solutions in subsequent class discussions enables students to appreciate the availability of alternative solutions as proposed by their classmates. Following this approach students not only learn the details of IR techniques, but significantly, naturally learn to apply them in solution of problems. In doing this they not only gain an appreciation of alternative solutions to a problem, but also how to assess their relative strengths and weaknesses. Developing confidence and skills in problem solving enables student assessment to be structured around solution of problems. Thus students can be assessed on the basis of their understanding and ability to apply techniques, rather simply their skill at reciting facts. This has the additional benefit of encouraging general problem solving skills which can be of benefit in other subjects. This approach to teaching IR was successfully implemented in an undergraduate module where students were assessed in a written examination exploring their knowledge and understanding of the principles of IR and their ability to apply them to solving problems, and a written assignment based on developing an individual research proposal

t-channel Approach to Reggeon Interactions in QCD

Starting from the multi-Regge effective action for high-energy scattering in QCD a $t$-channel approach can be developed which is similar to the approach by White based on general Regge arguments. The BFKL kernel of reggeized gluon interaction, contributions to the $2 \rightarrow 4$ reggeized gluon vertex function and the one-loop correction to the BFKL kernel are considered. The conditions are discussed under which this approach can provide a simple estimante of the next-to-leading logarithmic corrections to the BFKL perturbative pomeron intercept.Comment: latex , 17 figures appended as compressed uuencoded eps file

Heavy quark production as sensitive test for an improved description of high energy hadron collisions

QCD dynamics at small quark and gluon momentum fractions or large total energy, which plays a major role for HERA, the Tevatron, RHIC and LHC physics, is still poorly understood. For one of the simplest processes, namely bottom-antibottom production, next-to-leading-order perturbation theory fails. We show that the combination of two recently developed theoretical concepts, the k_perp-factorization and the next-to-leading-logarithmic-approximation BFKL vertex, gives perfect agreement with data. One can therefore hope that these concepts provide a valuable foundation for the description of other high energy processes.Comment: RevTeX, 4 pages, 7 figures titel and abstract changed, several formulations modified in the text, 1 figure droppe

Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion

Recent descriptions of significant heterogeneity in normal stem cells and cancers have altered our understanding of tumorigenesis, emphasizing the need to understand how single stem cells are subverted to cause tumors. Human myeloproliferative neoplasms (MPNs) are thought to reflect transformation of a hematopoietic stem cell (HSC) and the majority harbor an acquired V617F mutation in the JAK2 tyrosine kinase, making them a paradigm for studying the early stages of tumor establishment and progression. The consequences of activating tyrosine kinase mutations for stem and progenitor cell behavior are unclear. In this article, we identify a distinct cellular mechanism operative in stem cells. By using conditional knock-in mice, we show that the HSC defect resulting from expression of heterozygous human JAK2V617F is both quantitative (reduced HSC numbers) and qualitative (lineage biases and reduced self-renewal per HSC). The defect is intrinsic to individual HSCs and their progeny are skewed toward proliferation and differentiation as evidenced by single cell and transplantation assays. Aged JAK2V617F show a more pronounced defect as assessed by transplantation, but mice that transform reacquire competitive self-renewal ability. Quantitative analysis of HSC-derived clones was used to model the fate choices of normal and JAK2-mutant HSCs and indicates that JAK2V617F reduces self-renewal of individual HSCs but leaves progenitor expansion intact. This conclusion is supported by paired daughter cell analyses, which indicate that JAK2-mutant HSCs more often give rise to two differentiated daughter cells. Together these data suggest that acquisition of JAK2V617F alone is insufficient for clonal expansion and disease progression and causes eventual HSC exhaustion. Moreover, our results show that clonal expansion of progenitor cells provides a window in which collaborating mutations can accumulate to drive disease progression. Characterizing the mechanism(s) of JAK2V617F subclinical clonal expansions and the transition to overt MPNs will illuminate the earliest stages of tumor establishment and subclone competition, fundamentally shifting the way we treat and manage cancers

Energy-resolved electron-spin dynamics at surfaces of p-doped GaAs

Electron-spin relaxation at different surfaces of p-doped GaAs is investigated by means of spin, time and energy resolved 2-photon photoemission. These results are contrasted with bulk results obtained by time-resolved Faraday rotation measurements as well as calculations of the Bir-Aronov-Pikus spin-flip mechanism. Due to the reduced hole density in the band bending region at the (100) surface the spin-relaxation time increases over two orders of magnitude towards lower energies. At the flat-band (011) surface a constant spin relaxation time in agreement with our measurements and calculations for bulk GaAs is obtained.Comment: 6 pages, 4 figure

Shaping Robust System through Evolution

Biological functions are generated as a result of developmental dynamics that form phenotypes governed by genotypes. The dynamical system for development is shaped through genetic evolution following natural selection based on the fitness of the phenotype. Here we study how this dynamical system is robust to noise during development and to genetic change by mutation. We adopt a simplified transcription regulation network model to govern gene expression, which gives a fitness function. Through simulations of the network that undergoes mutation and selection, we show that a certain level of noise in gene expression is required for the network to acquire both types of robustness. The results reveal how the noise that cells encounter during development shapes any network's robustness, not only to noise but also to mutations. We also establish a relationship between developmental and mutational robustness through phenotypic variances caused by genetic variation and epigenetic noise. A universal relationship between the two variances is derived, akin to the fluctuation-dissipation relationship known in physics

Resummation of Yukawa enhanced and subleading Sudakov logarithms in longitudinal gauge boson and Higgs production

Future colliders will probe the electroweak theory at energies much larger than the gauge boson masses. Large double (DL) and single (SL) logarithmic virtual electroweak Sudakov corrections lead to significant effects for observable cross sections. Recently, leading and subleading universal corrections for external fermions and transverse gauge boson lines were resummed by employing the infrared evolution equation method. The results were confirmed at the DL level by explicit two loop calculations with the physical Standard Model (SM) fields. Also for longitudinal degrees of freedom the approach was utilized for DL-corrections via the Goldstone boson equivalence theorem. In all cases, the electroweak Sudakov logarithms exponentiate. In this paper we extend the same approach to both Yukawa enhanced as well as subleading Sudakov corrections to longitudinal gauge boson and Higgs production. We use virtual contributions to splitting functions of the appropriate Goldstone bosons in the high energy regime and find that all universal subleading terms exponentiate. The approach is verified by employing a non-Abelian version of Gribov's factorization theorem and by explicit comparison with existing one loop calculations. As a side result, we obtain also all top-Yukawa enhanced subleading logarithms for chiral fermion production at high energies to all orders. In all cases, the size of the subleading contributions at the two loop level is non-negligible in the context of precision measurements at future linear colliders.Comment: 32 pages, 7 figures, uses LaTeX2

Double parton distributions in the leading logarithm approximation of perturbative QCD

Recent CDF measurements of the inclusive cross section for a double parton scattering attach a great importance to any theoretical calculations of two-particle distribution functions. Using a parton interpretation of the leading logarithm diagrams of perturbative QCD theory, generalized Lipatov-Altarelli-Parisi-Dokshitzer equations for the two-parton distributions are re-obtained. The solutions of these equations are not at all the product of two single-parton distributions what is usually applied to the current analysis as ansatz.Comment: 8 pages, LaTe