Psychedelics and environmental virtues

The urgent need for solutions to critical environmental challenges is well attested, but often environmental problems are understood as fundamentally collective action problems. However, to solve to these problems, there is also a need to change individual behavior. Hence, there is a pressing need to inculcate in individuals the environmental virtues — virtues of character that relate to our environmental place in the world. We propose a way of meeting this need, by the judicious, safe, and controlled administration of “classic” psychedelic drugs as a way to catalyze the development of environmental virtues – a form of moral bio-enhancement. Recent evidence shows that psychedelics can be given safely in controlled environments, and can induce vivid experiences of unity and connectedness. These experiences, in turn, can durably increase feelings of nature-relatedness and pro-environmental behaviors. Therefore, we argue that responsible psychedelic use can reliably catalyze the development of a key environmental virtue known as living in place. This is a “master environmental virtue” that subsumes the qualities of respect for nature, proper humility, and aesthetic wonder and awe. Our account advances the environmental virtues debate by introducing a relevant practical proposal, and advances the psychedelic moral enhancement debate by providing a much-needed conceptual framework

Episodic, compression-driven fluid venting in layered sedimentary basins

Fluid venting phenomena are prevalent in sedimentary basins globally. Offshore, these localised fluid-expulsion events are archived in the geologic record via the resulting pockmarks at the sea-floor. Venting is widely interpreted to occur via hydraulic fracturing, which requires near-lithostatic pore pressures for initiation. One common driver for these extreme pressures is horizontal tectonic compression, which pressurises the entire sedimentary column over a wide region. Fluid expulsion leads to a sudden, local relief of this pressure, which then gradually recharges through continued compression, leading to episodic venting. Pressure recharge will also occur through pressure diffusion from neighboring regions that remain pressurised, but the combined role of compression and pressure diffusion in episodic venting has not previously been considered. Here, we develop a novel poroelastic model for episodic, compression-driven venting. We show that compression and pressure diffusion together set the resulting venting period. We derive a simple analytical expression for this venting period, demonstrating that pressure diffusion can significantly reduce the venting period associated with a given rate of compression and allowing this rate of compression to be inferred from observations of episodic venting. Our results indicate that pressure diffusion is a major contributor to episodic fluid venting in mudstone-dominated basins

Episodic fluid venting from sedimentary basins fuelled by pressurised mudstones

Subsurface sandstone reservoirs sealed by overlying, low-permeability layers provide capacity for long-term sequestration of anthropogenic waste. Leakage can occur if reservoir pressures rise sufficiently to fracture the seal. Such pressures can be generated within the reservoir by vigorous injection of waste or, over thousands of years, by natural processes. In either case, the precise role of intercalated mudstones in the long-term evolution of reservoir pressure remains unclear; these layers have variously been viewed as seals, as pressure sinks or as pressure sources. Here, we use the geological record of episodic fluid venting in the Levant Basin to provide striking evidence for the pressure-source hypothesis. We use a Bayesian framework to combine recently published venting data, which record critical subsurface pressures since $\sim$2 Ma, with a stochastic model of pressure evolution to infer a pressure-recharge rate of $\sim$30 MPa/Myr. To explain this large rate, we quantify and compare a range of candidate mechanisms. We find that poroelastic pressure diffusion from mudstones provides the most plausible explanation for these observations, amplifying the $\sim$1 MPa/Myr recharge caused by tectonic compression. Since pressurised mudstones are ubiquitous in sedimentary basins, pressure diffusion from mudstones is likely to promote seal failure globally

Predictors of Adherence to a Structured Exercise Program and Physical Activity Participation in Community Dwellers after Stroke

Aim. To investigate predictors of adherence to group-based exercise and physical activity participation among stroke survivors. Methods. 76 stroke survivors participated (mean age 66.7 years). Adherence was the percentage of classes attended over one year. Physical activity was the average pedometer steps/day measured over seven days at the end of the trial. Possible predictors included baseline measures of demographics, health, quality of life, falls, fear of falling, cognition, and physical functioning. Results. Mean class attendance was 60% (SD 29%). Only one variable (slow choice stepping reaction time) was an independent predictor of higher class attendance, explaining 5% of the variance. Participants completed an average of 4,365 steps/day (SD 3350). Those with better physical functioning (choice stepping reaction time, postural sway, maximal balance range, 10-m walk, or 6-min walk) or better quality of life (SF-12 score) took more steps. A model including SF-12, maximal balance range, and 6-min walk accounted for 33% of the variance in average steps/day. Conclusions. The results suggest that better physical functioning and health status are predictors of average steps taken per day in stroke survivors and that predicting adherence to group exercise in this group is difficult

Predictors of Adherence to a Structured Exercise Program and Physical Activity Participation in Community Dwellers after Stroke

Aim. To investigate predictors of adherence to group-based exercise and physical activity participation among stroke survivors. Methods. 76 stroke survivors participated (mean age 66.7 years). Adherence was the percentage of classes attended over one year. Physical activity was the average pedometer steps/day measured over seven days at the end of the trial. Possible predictors included baseline measures of demographics, health, quality of life, falls, fear of falling, cognition, and physical functioning. Results. Mean class attendance was 60% (SD 29%). Only one variable (slow choice stepping reaction time) was an independent predictor of higher class attendance, explaining 5% of the variance. Participants completed an average of 4,365 steps/day (SD 3350). Those with better physical functioning (choice stepping reaction time, postural sway, maximal balance range, 10-m walk, or 6-min walk) or better quality of life (SF-12 score) took more steps. A model including SF-12, maximal balance range, and 6-min walk accounted for 33% of the variance in average steps/day. Conclusions. The results suggest that better physical functioning and health status are predictors of average steps taken per day in stroke survivors and that predicting adherence to group exercise in this group is difficult

Exercise intervention to prevent falls and enhance mobility in community dwellers after stroke: a protocol for a randomised controlled trial

Background: Stroke is the most common disabling neurological condition in adults. Falls and poor mobility are major contributors to stroke-related disability. Falls are more frequent and more likely to result in injury among stroke survivors than among the general older population. Currently there is good evidence that exercise can enhance mobility after stroke, yet ongoing exercise programs for general community-based stroke survivors are not routinely available. This randomised controlled trial will investigate whether exercise can reduce fall rates and increase mobility and physical activity levels in stroke survivors. Methods and design: Three hundred and fifty community dwelling stroke survivors will be recruited. Participants will have no medical contradictions to exercise and be cognitively and physically able to complete the assessments and exercise program. After the completion of the pre-test assessment, participants will be randomly allocated to one of two intervention groups. Both intervention groups will participate in weekly group-based exercises and a home program for twelve months. In the lower limb intervention group, individualised programs of weight-bearing balance and strengthening exercises will be prescribed. The upper limb/cognition group will receive exercises aimed at management and improvement of function of the affected upper limb and cognition carried out in the seated position. The primary outcome measures will be falls (measured with 12 month calendars) and mobility. Secondary outcome measures will be risk of falling, physical activity levels, community participation, quality of life, health service utilisation, upper limb function and cognition. Discussion: This study aims to establish and evaluate community-based sustainable exercise programs for stroke survivors. We will determine the effects of the exercise programs in preventing falls and enhancing mobility among people following stroke. This program, if found to be effective, has the potential to be implemented within existing community services. Trial registration: The protocol for this study is registered with the Australian New Zealand Clinical Trials Registry (ACTRN12606000479505)

Architectures of the Text: An Inquiry Into the Hypnerotomachia Poliphili

Architectures of the Text: An Inquiry Into the Hypnerotomachia Poliphili A symposium to celebrate the acquisition of the second edition of the Hypnerotomachia Poliphili (1545) by the University of Pennsylvania Libraries. Website To download podcasts of the lectures, select the additional files below. Files in .mp4 format include images; files in .mp3 format are audio only. To download the symposium program, select download button at right. In April 2011, the University of Pennsylvania Libraries acquired a copy of the uncommon second edition of Francesco Colonna’s Hypnerotomachia Poliphili (Venice 1545). Since the appearance of the first edition in 1499, the Hypnerotomachia Poliphili has been heralded as the most beautiful book to appear in the Italian Renaissance. Printed in Venice by Aldus Manutius, “The Dream of Poliphily” was admired by Aldus’s contemporaries for its scholarship and value as an architectural treatise. Forty-six years after the publication of the first edition, Aldus’s heirs printed a second edition in 1545. This second edition suggests a renewed interest in the work, within Italy and beyond, for within a year a French translation appeared, followed by an English translation in 1592. Celebrated for its typographical design and illustrations, the Hypnerotomachia continues to attract the interest of scholars, typophiles, and collectors; it remains available in modern scholarly editions in both print and electronic format. The University of Pennsylvania Libraries\u27 acquisition came at the suggestion of John Dixon Hunt, Professor Emeritus of Landscape Architecture at the University. Funds for its purchase came from the G. Holmes Perkins Books and Archives Fund, established by G. Holmes Perkins, Professor of Architecture and Urbanism and former dean of the Graduate School of Fine Arts (now the School of Design). The Libraries and the School of Design administer this fund jointly. On February 11, 2012, the Anne and Jerome Fisher Fine Arts Library, the Rare Book and Manuscript Library, and the School of Design collaborated on a one-day symposium to celebrate the acquisition of the Hypnerotomachia. Presentations took place in the Class of \u2755 room, Van Pelt-Dietrich Library. Program: 10:30am-11:30am Movement 1: Books and Histories Welcome: David McKnight William B. Keller, Hypnerotomachia Joins the Perkins Library: Collecting to Support Persuasion in Architectural Design and History Eric Pumroy, Remarks on the 1499 Hypnerotomachia Poliphili at Bryn Mawr Special Collections John Dixon Hunt, Hypnerotomachia Poliphili: A Child\u27s Guide to the Story Line and a Look at its Afterlives Lynne Farrington, \u27Though I could lead a quiet and peaceful life, I have chosen one full of toil and trouble\u27: Aldus Manutius and the Printing History of the Hypnerotomachia Poliphili 11:30am-1:00pm Movement 2: Words and Interpretations Victoria Kirkham, Hypno What? A Dreamer\u27s Vision and the Reader\u27s Nightmare Ann Moyer, The Wanderings of Poliphilo through Renaissance Studies Ian White, Multiple Words, Multiple Meanings in the Hypnerotomachia 2:00pm-3:00pm Movement 3: Art and Illustration Chris Nygren, The Hypnerotomachia and Italian Art Circa 1500 Larry Silver, Not Hypnerotomachia: Venice\u27s Other Early Woodcut Illustrations 3:00pm-4:30pm Movement 4: Imagined Architectures Raffaella Fabiani Giannetto, \u27Not before either known or dreamt of\u27: The Hypnerotomachia Poliphili and the Craft of Wonder David Leatherbarrow, What Fragments are to Desire, Elements are to Design Ian White, Mathematical Design in Poliphilo\u27s Imaginary Building, The Temple of Venus 4:30pm-5:00pm Break and Interlude Shushi Yoshinaga, Hypnerotomachia Poliphili: A Modern Heritage : a display of objects and images 5:00pm-6:00pm Movement 5: Contemporary Resonances and Final Observation

Remote home monitoring (virtual wards) for confirmed or suspected COVID-19 patients:a rapid systematic review

Background: the aim of this review was to analyze the implementation and impact of remote home monitoring models (virtual wards) for confirmed or suspected COVID-19 patients, identifying their main components, processes of implementation, target patient populations, impact on outcomes, costs and lessons learnt. Methods: we carried out a rapid systematic review on models led by primary and secondary care across seven countries (US, Australia, Canada, The Netherlands, Ireland, China, UK). The main outcomes included in the review were: impact of remote home monitoring on virtual length of stay, escalation, emergency department attendance/reattendance, admission/readmission and mortality. The search was updated on February 2021. We used the PRISMA statement and the review was registered on PROSPERO (CRD: 42020202888). Findings: the review included 27 articles. The aim of the models was to maintain patients safe in the appropriate setting. Most models were led by secondary care and confirmation of COVID-19 was not required (in most cases). Monitoring was carried via online platforms, paper-based systems with telephone calls or (less frequently) through wearable sensors. Models based on phone calls were considered more inclusive. Patient/career training was identified as a determining factor of success. We could not reach substantive conclusions regarding patient safety and the identification of early deterioration due to lack of standardized reporting and missing data. Economic analysis was not reported for most of the models and did not go beyond reporting resources used and the amount spent per patient monitored. Interpretation: future research should focus on staff and patient experiences of care and inequalities in patients' access to care. Attention needs to be paid to the cost-effectiveness of the models and their sustainability, evaluation of their impact on patient outcomes by using comparators, and the use of risk-stratification tools

Brain volume in Tanzanian children with sickle cell anaemia: A neuroimaging study

Brain injury is a common complication of sickle cell anaemia (SCA). White matter (WM) and cortical and subcortical grey matter (GM), structures may have reduced volume in patients with SCA. This study focuses on whether silent cerebral infarction (SCI), vasculopathy or anaemia affects WM and regional GM volumes in children living in Africa. Children with SCA (n = 144; aged 5-20 years; 74 male) and sibling controls (n = 53; aged 5-17 years; 29 male) underwent magnetic resonance imaging. Effects of SCI (n = 37), vasculopathy (n = 15), and haemoglobin were assessed. Compared with controls, after adjusting for age, sex and intracranial volume, patients with SCA had smaller volumes for WM and cortical, subcortical and total GM, as well as bilateral cerebellar cortex, globus pallidus, amygdala and right thalamus. Left globus pallidus volume was further reduced in patients with vasculopathy. Putamen and hippocampus volumes were larger in patients with SCA without SCI or vasculopathy than in controls. Significant positive effects of haemoglobin on regional GM volumes were confined to the controls. Patients with SCA generally have reduced GM volumes compared with controls, although some subcortical regions may be spared. SCI and vasculopathy may affect the trajectory of change in subcortical GM and WM volume. Brain volume in non-SCA children may be vulnerable to contemporaneous anaemia