ВЛИЯНИЕ ПРОДЛЕННОЙ ТЕРАПИИ ЭНОКСАПАРИНОМ НА РИСК РЕЦИДИВА ВЕНОЗНЫХ ТРОМБОЭМБОЛИЧЕСКИХ ОСЛОЖНЕНИЙ И РЕКАНАЛИЗАЦИЮ ТРОМБИРОВАННЫХ ВЕН

The article presents the results of its own study of the effect of long-term (not less than 30 days) enoxa-parin therapy (1 mg/kg administered subcutaneously every 12h) on the risk of recurrent venous thromboembolic complications (VTC) and recanalization of thrombosed deep veins. The enoxaparin therapy was compared with a standard approach to treatment (unfractionated heparin for not less than 5 days followed by the administration of warfarin). The extended enoxaparin therapy was significantly more effective than standard treatment due to its impact on the risk of recurrent deep vein thrombosis (DVT) and recanalization of thrombosed deep veins. On top of that, the effect of enoxaparin in the first month of treatment of VTC episodes last for the next 11 months. As a result, the extension of enoxaparin therapy was associated with an 88% reduction in the risk of DVT recurrence during 12 months of anticoagulant therapy and a 2.5-fold increase in the probability of recanalization of venous occlusions by the end of the first year of treatment compared with the standard therapy with unfractionated heparin and warfarin.В статье представлены результаты собственного исследования, посвященного изучению влияния продленной (не менее 30 дней) терапии эноксапарином (1 мг/кг подкожно каждые 12 часов) на риск рецидива венозных тромбоэмбо-лических осложнений (ВТЭО) и реканализацию тромбированных глубоких вен. Для этого терапию эноксапарином сравнили со стандартным подходом к лечению (нефракционированный гепарин не менее 5 дней с переходом на прием варфарина). Продленная терапия эноксапарином оказалась значительно эффективнее стандартного лечения по влиянию на риск рецидива тромбоза глубоких вен (ТГВ) и реканализацию тромбированных глубоких вен. При этом эффект от применения эноксапарина в первый месяц лечения эпизода ВТЭО сохранялся на протяжении последующих 11 месяцев. Так, продление терапии эноксапарином ассоциировалось со снижением риска рецидива ТГВ в течение 12 месяцев анти-коагулянтной терапии на 88% и с увеличением вероятности реканализации венозных окклюзий к концу первого года лечения в 2,5 раза по сравнению со стандартной терапией нефракционированным гепарином и варфарином

Relationship study between the student learning approach in the occupational safety and health field and acquired competencies

Purpose: To search for training methods for specialists in industrial safety, environmental and occupational safety and health in conditions of insufficient (or absent) laboratory support and to study the relationship between the student learning approach and acquired competencies. Design/methodology/approach: To study modern advances in industrial safety, environmental and occupational safety and health and training methods for specialists a systematic literature review approach has been used. For publications from 2017, queries were asked through keywords and safety related topics. To relationship study between the student learning approach and acquired competencies a student survey on random sampling has been used. A total of 112 students of the 3rd and 4th year of study at the university were interviewed. Findings: The results of the survey showed that the students’ number who simultaneously successfully answered theoretical questions and completed practical tasks is 33.8% from the group with theoretical training and 75% from the group that was trained in the workplace. The relationship between the groups with a visit to the existing enterprise and acquired competencies was justified by the association coefficient and contingency coefficient that are 0.7 and 0.4 respectively. Research limitations/implications: A student’s survey was conducted at only one university. Questions were asked only according to the curriculum of the course “Labour Protection”. No survey for other training courses conducted. Practical implications: The research results are reasonable and can be applied at universities to improve the educational process of training specialists. Originality/value: It was proposed that students be trained using existing enterprises as a laboratory base and by the methods of statistics mathematical processing was substantiated the proposal feasibility

Developed jet-centrifugal spray devices: experimental testing to establish the possibility of their application in plants spraying technologies

Purpose: Experimentally substantiate the possibility of using the developed jet-centrifugal spraying device in plants spraying technologies. Design/methodology/approach: Many years of experience in creating spraying devices for solving practical problems in various industries made it possible to propose a design diagram of a single-phase jet-centrifugal spraying device. The tests were aimed at achieving device characteristics that are acceptable for use in plants spraying technologies such as jet coverage distance, droplet size and droplet deposition area (spray diameter). For this a several tests series with different design parameters was done. Before testing, the tightness of the device body was checked (the holding time under a pressure of 1 MPa is not less than 2 minutes). Findings: Based on the obtained jet coverage distance, droplet size and droplet deposition area, the developed spray device of some modifications can be used in plants spraying technologies. However, it is necessary to determine the quality of the spray device according to the BCPC classification; the device should be tested with some insecticides, fungicides and in plants spraying technologies to develop recommendations for their use. Research limitations/implications: The influence of design features of developed jetcentrifugal spray device on the jet coverage distance, droplet size and droplet deposition area was studied. Practical implications: The results obtained are useful in the field of improving national plants spraying technologies in order to improve the quality of the plant protection agent application and reduce the loss of the drug into the environment. Originality/value: To ensure maximum efficiency the proposed design of the jetcentrifugal spray device can be upgraded directly by the farmer by installing interchangeable nozzles that are attached with a union nut. Replaceable nozzles have different diameters and modifications and can be selected depending on the required jet coverage distance and spraying dispersion according to the current environmental conditions