7 research outputs found
Nonlinear equation for curved stationary flames
A nonlinear equation describing curved stationary flames with arbitrary gas
expansion , subject to the
Landau-Darrieus instability, is obtained in a closed form without an assumption
of weak nonlinearity. It is proved that in the scope of the asymptotic
expansion for the new equation gives the true solution to the
problem of stationary flame propagation with the accuracy of the sixth order in
In particular, it reproduces the stationary version of the
well-known Sivashinsky equation at the second order corresponding to the
approximation of zero vorticity production. At higher orders, the new equation
describes influence of the vorticity drift behind the flame front on the front
structure. Its asymptotic expansion is carried out explicitly, and the
resulting equation is solved analytically at the third order. For arbitrary
values of the highly nonlinear regime of fast flow burning is
investigated, for which case a large flame velocity expansion of the nonlinear
equation is proposed.Comment: 29 pages 4 figures LaTe
Self-Organization of Functional Coupling between Membrane and Calcium Clock in Arrested Human Sinoatrial Nodal Cells in Response to Camp
A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells
The mechanisms that generate pacemaking activity in human sinoatrial nodal cells are revealed.</jats:p
The COMAGMAT-5: Modeling the Effect of Fe–Ni Sulfide Immiscibility in Crystallizing Magmas and Cumulates
A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8
Adult (3 month) mice with cardiac-specific overexpression of adenylyl cyclase (AC) type VIII (TGAC8) adapt to an increased cAMP-induced cardiac workload (~30% increases in heart rate, ejection fraction and cardiac output) for up to a year without signs of heart failure or excessive mortality. Here, we show classical cardiac hypertrophy markers were absent in TGAC8, and that total left ventricular (LV) mass was not increased: a reduced LV cavity volume in TGAC8 was encased by thicker LV walls harboring an increased number of small cardiac myocytes, and a network of small interstitial proliferative non-cardiac myocytes compared to wild type (WT) littermates; Protein synthesis, proteosome activity, and autophagy were enhanced in TGAC8 vs WT, and Nrf-2, Hsp90α, and ACC2 protein levels were increased. Despite increased energy demands in vivo LV ATP and phosphocreatine levels in TGAC8 did not differ from WT. Unbiased omics analyses identified more than 2,000 transcripts and proteins, comprising a broad array of biological processes across multiple cellular compartments, which differed by genotype; compared to WT, in TGAC8 there was a shift from fatty acid oxidation to aerobic glycolysis in the context of increased utilization of the pentose phosphate shunt and nucleotide synthesis. Thus, marked overexpression of AC8 engages complex, coordinate adaptation "circuity" that has evolved in mammalian cells to defend against stress that threatens health or life (elements of which have already been shown to be central to cardiac ischemic pre-conditioning and exercise endurance cardiac conditioning) that may be of biological significance to allow for proper healing in disease states such as infarction or failure of the heart
EXPLANATION: Exoplanet and Transient Event Investigation Project—Optical Facilities and Solutions
Over the past decades, the achievements in astronomical instrumentation have given rise to a number of novel advanced studies related to the analysis of large arrays of observational data. One of the most famous of these studies is a study of transient events in the near and far space and a search for exoplanets. The main requirements for such kinds of projects are a simultaneous coverage of the largest possible field of view with the highest possible detection limits and temporal resolution. In this study, we present a similar project aimed at creating an extensive, continuously updated survey of transient events and exoplanets. To date, the core of the project incorporates several 0.07–2.5 m optical telescopes and the 6-m BTA telescope of the Special Astrophysical Observatory of RAS (Russia), a number of other Russian observatories and the Bonhyunsan observatory of the Korea Astronomy and Space Science Institute (South Korea). Our attention is mainly focused on the description of two groups of small, wide-angle optical telescopes for primary detection. All the telescopes are originally designed for the goals of the project and may be of interest to the scientific community. A description is also given for a new, high-precision optical spectrograph for the Doppler studies of transient and exoplanet events detected within the project. We present here the philosophy, expectations and first results obtained during the first year of running the project