Ischemic stroke in a pediatric patient – a case report

Background Childhood ischemic stroke (AIS) is a relatively rare disease with an estimated incidence of 1.3-13/100,000/year. It most commonly affects children under the age of 5. Major risk factors include arteriopathies, heart disease, hypercoagulable states and infections. Case report A 2-year-old patient was admitted to the Department of Neurology at the University Children's Hospital in Lublin after suffering a head injury 3 days earlier. Neurological examination revealed features of left hemiparesis. A CT scan revealed an uncharacteristic hypodense, poorly demarcated area, an indication for further diagnostics. MR imaging revealed diffuse ischemic lesions. Angio-MR showed a lack of signal within the branches of the right posterior cerebral artery. Based on the clinical picture and additional examinations, a diagnosis of ischemic stroke was made and pharmacological treatment was implemented. To determine the cause of the stroke, an echocardiogram was performed, which showed flaccid atrial septal tissue with a defect and a trace left-right leak. Genetic testing for congenital thrombophilia confirmed a 4G/4G polymorphism in the PAI-1 gene. Conclusions Ischemic stroke is a life-threatening condition that requires prompt diagnosis and appropriate treatment. The relatively rare occurrence among children and nonspecific symptoms may result in difficulties in making a definitive diagnosis. Each case of stroke in children requires a comprehensive diagnosis including neuroimaging studies and identification of specific risk factors

Użyteczność, funkcjonalność i dostępność stron internetowych muzeów i instytucji kultury

Ze wstępu: "Niewątpliwie Internet jest jednym z głównych źródeł informacji. Stronę internetową może stworzyć każdy. Służą do tego odpowiednie narzędzia, które bez specjalistycznej wiedzy programistycznej pozwalają na publikowanie treści. Niemniej jednak wraz z rozwojem technologicznym i rosnącym zapotrzebowaniem na realizację dostępnych na co dzień usług z wykorzystaniem sieci Internet, rola witryn ulegała rozbudowaniu. Stąd też strony internetowe, od początkowo jedynie informacyjnych, zaczęły pełnić także funkcje m.in. marketingowe, kontaktowe, komunikacyjne, rezerwacyjne, płatnicze, personalizujące, czy też edukacyjne."(...

Studies on toxicity of selected Oomycetes

The MTT test is used to determine the cytotoxicity of species: Achlya americana, A. caroliniana, Leptomitus lacteus, Saprolegnia ferax and S. lapponica, which occurred in Lake Sitno in the Drawieński National Park (W Poland). It was stated that among five examined species of zoosporic fungi only one of them A. caroliniana, does not show cytotoxic effect. Low and mean toxicity of other tested water FLO, however, combined with the large-scale character of their appearance shows, that they can create serious threat for the spawn, fry, fish as well as the other organisms (including invertebrates) existing in water

How electronic devices affect the sleep of young people: summary of current knowledge

Introduction and purpose: The impact of electronic devices on our daily lives is becoming increasingly significant. The contemporary generation of young people is growing up in a world where smartphones, tablets, computers, and other electronic devices are widely available and utilized. Scientists are contemplating the challenges posed by excessive exploitation of electronics on the health of young individuals. The aim of the article is to present the harmful effects of using electronic devices before sleep in young people, considering medical aspects such as sleep disorders and their influence on overall psychophysical health. Summary: Electronic devices negatively affect the sleep of young people by reducing sleep time and delaying the sleep onset phase. The main problem is the use of electronic devices without time limits. In the era of technology, it is significantly important to raise awareness among young people about the importance of sleep hygiene and how blue light emitted by electronic devices affects its quality

Quantum anomaly detection in the latent space of proton collision events at the LHC

We propose a new strategy for anomaly detection at the LHC based on unsupervised quantum machine learning algorithms. To accommodate the constraints on the problem size dictated by the limitations of current quantum hardware we develop a classical convolutional autoencoder. The designed quantum anomaly detection models, namely an unsupervised kernel machine and two clustering algorithms, are trained to find new-physics events in the latent representation of LHC data produced by the autoencoder. The performance of the quantum algorithms is benchmarked against classical counterparts on different new-physics scenarios and its dependence on the dimensionality of the latent space and the size of the training dataset is studied. For kernel-based anomaly detection, we identify a regime where the quantum model significantly outperforms its classical counterpart. An instance of the kernel machine is implemented on a quantum computer to verify its suitability for available hardware. We demonstrate that the observed consistent performance advantage is related to the inherent quantum properties of the circuit used

Pectus Excavatum: A review of current treatment possibilities

Anterior chest wall depression known as Pectus excavatum (PE) , is currently the most common congenital chest wall deformation, with incidence estimated at 1/400 births, five times more frequently in boys than girls (5:1 ratio in occurrence). 1 Etiology of this deformity is formed by several hypothesis, including overgrowth of the ribs, developmental failure of the bony thorax or weakness and abnormal flexibility of the sternum. While theoretical concepts of its origin may differ, the common ground is the characteristics of said deformation: a posterior depression of the sternum and the lower costal cartilages. 2Surgical treatment options were described since 1949 with Ravitch procedure and since then a number of new ones has been developed. For many years Ravitch and Nuss procedures were the main way to treat pectus excavatum, with a growing bias towards latter one. Since the Nuss procedure characterizes with less invasive approach and fever overall complications 3 its popularity outgrew Ravitch procedure and currently is described as MIRPE – Minimally Invasive Pectus Excavatum Repair. 4 However afterward then many new techniques were developed, focusing on reducing overall procedure risks, improving patient safety and quality of life and including new technical possibilities. The aim of this study was to gather and evaluate current literature to highlight new treatment options

Cutaneous manifestations associated with COVID-19: summary of current knowledge

Introduction and purpose: Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had been spreading rapidly throughout the world, mainly affecting respiratory system. Except pulmonary symptoms, skin lesions might also occur. The precise percentage of patients with confirmed COVID-19 who presented cutaneous manifestations is still unknown (0.2% - 20.4%). Part of the skin lesions might be drug-induced. Brief description of the state of knowledge: Cutaneous manifestations in the course of the coronavirus disease could be divided into six main groups: maculopapular rash, urticarial lesions, chilblain‐like lesions, vesicular eruptions, petechial/purpuric lesions and livedoid lesions. The most common skin lesions are maculopapular eruptions (47%). Trunk is the most affected location, whereas pruritus is the most frequent additional symptom among patients with skin lesions associated with coronavirus disease. These lesions appear mainly in elderly patients except pseudo chilblains which are present among children and young adults with SARS-Cov-2 infection. The majority of cutaneous manifestations occur after COVID-19 systemic symptoms, but the appearance of vesicular lesions before the respiratory signs was also reported. Cutaneous manifestations resolved spontaneously at different times, ranging from a few days to 2-4 weeks. Moreover, patients with severe course of COVID-19 with maculopapular rash have better prognosis (2% mortality rate) in comparison to patients who developed livedoid lesions in course of the coronavirus disease (10% mortality rate). Summary: Pseudo-chilblains and vesicular lesions are the most specific cutaneous manifestations of coronavirus disease. Healthcare professionals should pay attention to patients who present skin symptoms in the course of COVID-19. Cutaneous manifestations can facilitate the doctor the diagnosis and even estimate the severity of coronavirus disease

New Physics Agnostic Selections For New Physics Searches

We discuss a model-independent strategy for boosting new physics searches with the help of an unsupervised anomaly detection algorithm. Prior to a search, each input event is preprocessed by the algorithm - a variational autoencoder (VAE). Based on the loss assigned to each event, input data can be split into a background control sample and a signal enriched sample. Following this strategy, one can enhance the sensitivity to new physics with no assumption on the underlying new physics signature. Our results show that a typical BSM search on the signal enriched group is more sensitive than an equivalent search on the original dataset

Influence of surgically inducted weight loss on sexual function of obese male patients - literature overview

Introduction:  Obesity is one of the most challenging and popular problem in nowadays society. Overweight and obesity are connected with chronic complications, such as arterial hypertension, atherosclerotic cardiovascular disease and type 2 diabetes. Nonsurgical methods of weight loss were not positively conducted in significant part of obese population. It has given a chance to develop part of medicine known as bariatric surgery. Obesity is identified as an risk factor for sexual dysfunction.  The aim of this article is to summarize the main findings of studies about the influence of bariatric surgery on sexual functions of obese male patients.    Materials and methods: The study is based on medical articles gathered from PubMed database spanning the years 2016-2023 and article from National Institutes of Health and from Nutritionhospitalaria. The research was conducted through the analysis of keywords such as ”Obesity”, „Bariatric Surgery”, Sexual Dysfunction”, „Men”.    Results: This review indicated that surgically inducted weight loss could improve sexual function in obese men. It is connected with important increase in IIEF score and serum testosteron level. It is a need for further clinical studies to explore association of sexual function after bariatric surgery.&nbsp