23 research outputs found
Transition Metal Catalyzed Formation and Transformations of allylic N,O-acetals with a focus on olefinic a-amino acids
Transition Metal Catalyzed Formation and Transformations of allylic N,O-acetals with a focus on olefinic a-amino acids
Assymetric Synthesis Of Acetomycin
The synthesis of (-)-acetomycin 1, a highly functionalized gamma-lactone with antitumer activity, was achieved in five steps with nearly comlete enantioselectivity. The key step was realized by a large scale lipase R catalyzed esterification 0f 5-hydroxy-4-methyl-2(5H)-furanone 2 providing (-)-(5R)-5-acetoxy-4-methyl-2(5H)-furanone 3 with an e.e of 99%.
A ring-closing metathesis-mediated route to novel enantiopure conformationally restricted cyclic amino acids.
Phosphine-catalyzed [3+2] annulation of cyanoallenes
Cyanoallenes were successfully used in organophosphine-catalyzed [3+2]-type annulation to give cyano-substituted dihydropyrroles in good yield. Chiral phosphines were also screened, leading to some initial results in the asymmetric version of cyanoallene-based annulations