自己組織化高分子材料 : 両親媒性分子の設計からナノ構造制御へ

京都大学0048新制・課程博士博士(工学)甲第22846号工博第4786号新制||工||1748(附属図書館)京都大学大学院工学研究科高分子化学専攻(主査)教授 大内 誠, 教授 竹中 幹人, 教授 秋吉 一成学位規則第4条第1項該当Doctor of Philosophy (Engineering)Kyoto UniversityDGA

Domain Nucleation and Annihilation in Uniformly Magnetized State under Current Pulses in Narrow Ferromagnetic Wires

We investigate the current-driven magnetization dynamics in narrow Permalloy wires by means of Lorentz microscopy and electron holography. Current pulses are found to transform the magnetic structure in the uniformly magnetized state below the Curie temperature. A variety of magnetic states including reversed magnetic domains are randomly obtained in low probability. The dynamics of vortices found in most of observed magnetic states seems to play a key role in triggering the magnetization reversal.Comment: 11 pages, 3 figures, 1 video, to appear in Japanese Journal of Applied Physics (Express Letter

Clinical Study on Slight Fever

Between May 1981 and April 1986, 1402 patients were admitted to the Department of Primary Care Medicine of Kawasaki Medical School Hospital. Of these, 452 patients had a slight fever ranging from 37.0°C to 37.9°C. We analyzed those patients clinically. Infection ranked first as the cause of slight fever, followed by malignancy, collagen disease and others. About 50% of the cases were of unknown origin, and many cases with CRP and ESR almost within the normal range convalesced satisfactorily. The measurement of CRP and ESR in slight fever patients were useful to exclude organic slight fever. The cases with a slight fever of unknown origin appearing for a long term also often had nonorganic diseases such as depression or neurosis. Almost all of these cases were placed in the category of habitual hyperthermia

Neural cell adhesion molecule expression and clinical features in small cell lung cancer: a semi-quantitative immunohistochemical approach using an immunogold-silver staining method.

The neural cell adhesion molecule (NCAM) is a family of cell surface sialoglycoproteins mediating homotypic and heterotypic cell-cell adhesion. In tumors, NCAM is supposed to be involved with the malignant features characterized by invasive growth and metastasis. In the present study, we evaluated the correlation between NCAM expression of tumors obtained from small cell lung cancer (SCLC) patients and the clinical outcome. NCAM expression was determined semi-quantitatively by an immunogold-silver staining method using the SCLC cluster 1 monoclonal antibody NCC-LU-243. Of 20 SCLC patients studied, six patients with tumors with high NCAM expression had a poor response to chemotherapy, and a short disease-free (p = 0.011) and overall (p = 0.003) survival as compared with 14 patients having tumors with low NCAM expression. These findings indicate that the therapeutic outcome of SCLC may be partly predicted by determining the NCAM expression of the tumor.</p

737–1 Heart Fatty Acid-binding Protein and Myoglobin can Accurately Detect Successful Reperfusion as Early as 15 Minutes After Reperfuslon

Human heart fatty acid-binding protein (FABP) is an abundant low molecular weight protein in cytoplasm of myocardial cell similar to myoglobin (Mb). To evaluate whether FABP can also detect successful reperfusion very early like Mb, we examined serum FABP and Mb levels in 45 patients (pts) undergoing PTCR or PTCA within 6 hours after the onset of acute myocardial infarction. Coronary angiography was performed every 5minutes (min) during reperfusion therapy to determine the exact time of reperfusion. In 30 pts with reperfusion (reperfused group: TIMI grade 3 [23 pts] and grade 2 [7 pts]), serum samples were taken just before and at 15, 30 and 60min after initial angiographic confirmation of reperfusion. In 15 pts without reperfusion (nonreperfused group), serum samples were taken just before and at 15, 30 and 60min after the initiation of therapy. FABP was measured by competitive enzyme immunoassay and Mb by latex agglutination turbidimetry. The FABP ratio (FABP after/FABP before) and Mb ratio (Mb after/Mb before) were calculated. FABP and Mb levels increased rapidly, peaked within 60min after reperfusion. The FABP and Mb ratios in the reperfused group significantly (p&lt;0.01) exceeded those in the nonreperfused group at 15, 30 and 60 min. The sensitivity (Sen) and specificity (Spe) of these markers for reperfusion were as follows:Criteria15 min30 min60 minSenSpeSenSpeSenSpeFABP ratio&gt;1.6*93%100%97%100%100%100%Mb ratio&gt;2.4**90%100%93%100%100%100%*mean +2SD at 60 min in the nonreperfused group**published criteriaConclusionFABP, like Mb could accurately detect successful reperfusion as early as 15min after reperfusion and could provide a high level of accuracy within 60min after reperfusion

Assessment of the Period for Administration of Antibiotics for Primary Atypical Pneumonia

We assessed adequate period for administration of antibiotics for primary atypical pneumonia (PAP). The subjects were patients with PAP admitted to our hospital from January, 1986 to December, 1988. For treatment, 100 mg of minocycline (MINO) was dissolved into 100 ml of solution and infused intravenously for 1 hour twice a day. The patients were divided into two treatment periods: a 6 day-administration group (Group A), and a 9 day-administration group (Group B). Group A: 23 cases (which included 8 cases of mycoplasmal pneumonia) and Group B: 22 cases (which included 10 cases of mycoplasmal pneumonia). A comparative assessment was made between Groups A and B regarding body temperature, WBC, erythrocyte sedimentation rate, CRP and chest X-ray on the 3rd, 6th and 9th days of treatment but no significant difference was observed. Residual shadows at the discontinuance of treatment were present in 61% of Group A and in 36% of Group B but they disappeared gradually in both groups. No recurrent cases were observed in either Group A or B within 1 month after treatment was finished. As for the PAP treatment period using an intravenous drip infusion of minocycline, no significant clinical difference was observed between administration for 6 and 9 days, suggesting that the 6 days administration suffices for treatment. Even though the possible bacterial residue was unknown as no separation of mycoplasma pneumoniae was attempted, there were no recurrent cases