Importance of Intellectual Property Rights for Building a Sustainable Future

Sustainability is a concept that has become popular in many fields, especially in recent years. On the other hand, the term sustainable development deals with the development and environmental goals together. At the same time, ecologically sustainable development is very important in the context of bioeconomy and green technology. For the globalization of this concept, Sustainable Development Goals (SDGs), also known as Global Goals, were established by the United Nations in 2015 under the leadership of the United Nations Development Programme (UNDP). With the SDGs, all economically active societies aim to innovate and improve the productions already made for truly sustainable development, where intellectual property rights (IPR) are very important in this sense. IPRs protect all tangible or intangible assets based on human intelligence and creativity and are manifested by an intellectual thinking system. These rights guarantee the owner of the idea the right to do what individual wants with the original cognitive product for a certain period of time. IPR is an important tool in the dissemination of technology. Especially in terms of dissemination of green technologies, it is beneficial in this sense. However, sometimes, this situation gets in the way of sustainability. Firstly, the concept of sustainability is explained, and then the bioeconomy and green technologies that developed around the concept of a sustainable future are mentioned here. Afterward, the relationship between IPR and sustainability is explained. Finally, the opportunities and drawbacks of the IPR concept are discussed in the context of sustainability. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023

Development of a serum free medium for HUMIRA® biosimilar by design of experiment approaches [Deney tasarimi yaklaşimlarini kullanarak HUMIRA® biyobenzeri için serumsuz ortam tasarimi]

2-s2.0-85090437698Background: Serum have been traditionally used to support growth of animal cell cultures. However, the increasing growth of therapeutic biopharmaceuticals market, accelerated the high demand for the serum-free medium (SFM). Objective: The main objective is to design a SFM for a stable rCHO cell line that produces a fully anti-human TNF-? monoclonal antibody (mAb) corresponding to HUMIRA® biosimilar. Materials and methods: Design of Experiment (DoE) approaches were used to determine the key factors due to their effect on specific growth rate and mAb production. The production was carried out in T-flasks at different initial cell concentrations and then in Erlenmeyers with the developed SFM. mAb production was compared with commercial SFMs in terms of yield and productivity. Results: Regarding to our findings, when the developed SFM-adapted cells were compared with the cells produced in commercial SFMs, the mAb productivity in developed SFM were higher (1.3-1.6 times) depending on higher mAb concentration and less (3-5 times) cell concentration. Additionally, the produced mAb in the developed SFM provided high conformational similarity with its originator HUMIRA®. Conclusion: DoE approaches could be used to reduce cost and time in designing SFM for any commercially important cell line to produce high value biologics. © 2020 De Gruyter. All rights reserved.EBILTEM-2014/BIL/017 112M685 Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITAKAcknowledgements: This work was supported through research grants from The Scientific and Technological Research Council of Turkey (TUBITAK) with a project number of 112M685 and also Ege University Science-Technology and Research Center with a project number of EBILTEM-2014/BIL/017. Ilgin KIMIZ-GEBOLOGLU and Oznur OZASLAN were supported by TUBITAK-2210-C National Scholarship Program for MSc Students