Optic Neuritis History Does Not Influence OCT Measurement in Long-Standing Secondary Progressive Multiple Sclerosis (.pdf)

Optical coherence tomography (OCT) is a useful outcome measure of neuronal integrity in relapsing-remitting MS (RRMS) trials. Its role in secondary progressive MS (SPMS) is promising but less well-understood. Retinal nerve fiber layer (RNFL) and macular thinning is generally attributed to prior optic neuritis (ON); however, OCT thinning in the absence of ON has also been demonstrated. This study addresses the influence of ON history on OCT readings in SPMS