Degradation of adhesion molecules of G361 melanoma cells by a non-thermal atmospheric pressure microplasma

Increased expression of integrins and focal adhesion kinase (FAK) is important for the survival, growth and metastasis of melanoma cells. Based on this well-established observation in oncology, we propose to use degradation of integrin and FAK proteins as a potential strategy for melanoma cancer therapy. A low-temperature radio-frequency atmospheric microplasma jet is used to study their effects on the adhesion molecules of G361 melanoma cells. Microplasma treatment is shown to (1) cause significant cell detachment from the bottom of microtiter plates coated with collagen, (2) induce the death of human melanoma cells, (3) inhibit the expression of integrin 2, integrin 4 and FAK on the cell surface and finally (4) change well-stretched actin filaments to a diffuse pattern. These results suggest that cold atmospheric pressure plasmas can strongly inhibit the adhesion of melanoma cells by reducing the activities of adhesion proteins such as integrins and FAK, key biomolecules that are known to be important in malignant transformation and acquisition of metastatic phenotypes

Stochastic String Motion Above and Below the World Sheet Horizon

We study the stochastic motion of a relativistic trailing string in black hole AdS_5. The classical string solution develops a world-sheet horizon and we determine the associated Hawking radiation spectrum. The emitted radiation causes fluctuations on the string both above and below the world-sheet horizon. In contrast to standard black hole physics, the fluctuations below the horizon are causally connected with the boundary of AdS. We derive a bulk stochastic equation of motion for the dual string and use the AdS/CFT correspondence to determine the evolution a fast heavy quark in the strongly coupled $\N=4$ plasma. We find that the kinetic mass of the quark decreases by $\Delta M=-\sqrt{\gamma \lambda}T/2$ while the correlation time of world sheet fluctuations increases by $\sqrt{\gamma}$.Comment: 27 pages, 5 figures; v2 final version, small changes, references adde

Spontaneous CP Violating Phase as The CKM Matrix Phase

We propose that the CP violating phase in the CKM mixing matrix is identical to the CP phases responsible for the spontaneous CP violation in the Higgs potential. A specific multi-Higgs model with Peccei-Quinn (PQ) symmetry is constructed to realize this idea. The CP violating phase does not vanish when all Higgs masses become large. There are flavor changing neutral current (FCNC) interactions mediated by neutral Higgs bosons at the tree level. However, unlike general multi-Higgs models, the FCNC Yukawa couplings are fixed in terms of the quark masses and CKM mixing angles. Implications for meson-anti-meson mixing, including recent data on $D-\bar D$ mixing, and neutron electric dipole moment (EDM) are studied. We find that the neutral Higgs boson masses can be at the order of one hundred GeV. The neutron EDM can be close to the present experimental upper bound.Comment: 16 pages, RevTex. Several typos corrected, and one reference adde

Bundle and annulus CHF correlations applicable for near critical pressure region

Paper presented at the 8th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, Mauritius, 11-13 July, 2011.Bundle and annulus CHF correlations are developed by using CHF experimental data from the Freon R-134a Thermal Hydraulic Experimental Loop developed at KAERI. The CHF data are in the range of the pressure of 3200 ~ 4030 kPa (Critical pressure of R-134a = 4059 kPa), the mass flux 150∼1500 kg/m2s, and the inlet subcooling 40 ~ 70 kJ/kg. We obtained local T/H values using a subchannel analysis code and produced CHF correlations for the matrix subchannel, coldwall subchannel and annulus channel, respectively. A subchannel code, The MATRA-α IBM PC version, is used to obtain the local conditions in a hot subchannel (CHF observed channel) in the 5x5 bundle geometry. All the CHF experimental data are successfully calculated by the present correlations with good prediction performance. The prediction accuracy of the correlations is not distorted by much in any of the ranges of the independent parameters. The bundle CHF correlations could help one to conceptually design a SCWR, by adopting a fluidto- fluid modeling technique for a CHF near a critical pressure.mp201

Spontaneous CP Violation in a SUSY Model with a complex CKM

It is pointed out that the recent measurement of the angle $\gamma$ of the unitarity triangle, providing irrefutable evidence for a complex Cabibbo-Kobayashi-Maskawa (CKM) matrix, presents a great challenge for supersymmetric models with spontaneous CP violation. We construct a new minimal extension of the minimal supersymmetric standard model (MSSM), with spontaneous CP breaking, which leads to a complex CKM matrix, thus conforming to present experimental data. This is achieved through the introduction of two singlet chiral superfields and a vector-like quark chiral superfield which mixes with the standard quarks. A $Z_3$ symmetry is introduced in order to have a potential solution to the strong CP problem.Comment: 12 pages. Uses the elsart.cls LaTeX class. Minor corrections and references adde

COSMOGRAIL: XVII. Time delays for the quadruply imaged quasar PG 1115+080

Indexación: Scopus.Acknowledgements. The authors would like to thank R. Gredel for his help in setting up the program at the ESO MPIA 2.2 m telescope, and the anonymous referee for his or her comments on this work. This work is supported by the Swiss National Fundation. This research made use of Astropy, a community-developed core Python package for Astronomy (Astropy Collaboration et al. 2013, 2018) and the 2D graphics environment Matplotlib (Hunter 2007). K.R. acknowledge support from PhD fellowship FIB-UV 2015/2016 and Becas de Doctorado Nacional CONICYT 2017 and thanks the LSSTC Data Science Fellowship Program, her time as a Fellow has benefited this work. M.T. acknowledges support by the DFG grant Hi 1495/2-1. G. C.-F. C. acknowledges support from the Ministry of Education in Taiwan via Government Scholarship to Study Abroad (GSSA). D. C.-Y. Chao and S. H. Suyu gratefully acknowledge the support from the Max Planck Society through the Max Planck Research Group for S. H. Suyu. T. A. acknowledges support by the Ministry for the Economy, Development, and Tourism’s Programa Inicativa Científica Milenio through grant IC 12009, awarded to The Millennium Institute of Astrophysics (MAS).We present time-delay estimates for the quadruply imaged quasar PG 1115+080. Our results are based on almost daily observations for seven months at the ESO MPIA 2.2 m telescope at La Silla Observatory, reaching a signal-to-noise ratio of about 1000 per quasar image. In addition, we re-analyze existing light curves from the literature that we complete with an additional three seasons of monitoring with the Mercator telescope at La Palma Observatory. When exploring the possible source of bias we considered the so-called microlensing time delay, a potential source of systematic error so far never directly accounted for in previous time-delay publications. In 15 yr of data on PG 1115+080, we find no strong evidence of microlensing time delay. Therefore not accounting for this effect, our time-delay estimates on the individual data sets are in good agreement with each other and with the literature. Combining the data sets, we obtain the most precise time-delay estimates to date on PG 1115+080, with Δt(AB) = 8.3+1.5 -1.6 days (18.7% precision), Δt(AC) = 9.9+1.1 -1.1 days (11.1%) and Δt(BC) = 18.8+1.6 -1.6 days (8.5%). Turning these time delays into cosmological constraints is done in a companion paper that makes use of ground-based Adaptive Optics (AO) with the Keck telescope. © ESO 2018.https://www.aanda.org/articles/aa/abs/2018/08/aa33287-18/aa33287-18.htm

Heavy quark in an expanding plasma in AdS/CFT

Using the Janik-Peschanski dual to a Bjorken flow, a Langevin equation is derived for a heavy quark in an expanding N = 4 supersymmetric Yang-Mills plasma. Such a plasma is characterized by a proper-time dependence of the temperature and corresponds to a system out of equilibrium. The analysis first focuses on a quark at rest in the plasma comoving frame. The case of a quark moving across a longitudinally expanding plasma is then considered. The two-point functions for the random noise acting on such heavy quark probes are computed.Comment: 17 pages. v2: references added; improved comments on the Schwinger-Keldysh formalis

Electroactive biofilms: new means for electrochemistry

This work demonstrates that electrochemical reactions can be catalysed by the natural biofilms that form on electrode surfaces dipping into drinking water or compost. In drinking water, oxygen reduction was monitored with stainless steel ultra-microelectrodes under constant potential electrolysis at )0.30 V/SCE for 13 days. 16 independent experiments were conducted in drinking water, either pure or with the addition of acetate or dextrose. In most cases, the current increased and reached 1.5–9.5 times the initial current. The current increase was attributed to biofilm forming on the electrode in a similar way to that has been observed in seawater. Epifluorescence microscopy showed that the bacteria size and the biofilm morphology depended on the nutrients added, but no quantitative correlation between biofilm morphology and current was established. In compost, the oxidation process was investigated using a titanium based electrode under constant polarisation in the range 0.10–0.70 V/SCE. It was demonstrated that the indigenous micro-organisms were responsible for the current increase observed after a few days, up to 60 mA m)2. Adding 10 mM acetate to the compost amplified the current density to 145 mA m)2 at 0.50 V/SCE. The study suggests that many natural environments, other than marine sediments, waste waters and seawaters that have been predominantly investigated until now, may be able to produce electrochemically active biofilm