Voter model on a directed network: Role of bidirectional opinion exchanges

The voter model with the node update rule is numerically investigated on a directed network. We start from a directed hierarchical tree, and split and rewire each incoming arc at the probability $p$. In order to discriminate the better and worse opinions, we break the $Z_2$ symmetry ($\sigma = \pm 1$) by giving a little more preference to the opinion $\sigma = 1$. It is found that as $p$ becomes larger, introducing more complicated pattern of information flow channels, and as the network size $N$ becomes larger, the system eventually evolves to the state in which more voters agree on the better opinion, even though the voter at the top of the hierarchy keeps the worse opinion. We also find that the pure hierarchical tree makes opinion agreement very fast, while the final absorbing state can easily be influenced by voters at the higher ranks. On the other hand, although the ordering occurs much slower, the existence of complicated pattern of bidirectional information flow allows the system to agree on the better opinion.Comment: 5 pages, 3 figures, Phys. Rev. E (in press

Double resonance in the infinite-range quantum Ising model

We study quantum resonance behavior of the infinite-range kinetic Ising model at zero temperature. Numerical integration of the time-dependent Schr\"odinger equation in the presence of an external magnetic field in the $z$ direction is performed at various transverse field strengths $g$. It is revealed that two resonance peaks occur when the energy gap matches the external driving frequency at two distinct values of $g$, one below and the other above the quantum phase transition. From the similar observations already made in classical systems with phase transitions, we propose that the double resonance peaks should be a generic feature of continuous transitions, for both quantum and classical many-body systems.Comment: 4 pages, 5 figure

Reentrant phase transition in a predator-prey model

We numerically investigate the six-species predator-prey game in complex networks as well as in $d$-dimensional hypercubic lattices with $d=1,2,..., 6$. The interaction topology of the six species contains two loops, each of which is composed of cyclically predating three species. As the mutation rate $P$ is lowered below the well-defined phase transition point, the $Z_2$ symmetry related with the interchange of the two loops is spontaneously broken, and it has been known that the system develops the defensive alliance in which three cyclically predating species defend each other against the invasion of other species. In the small-world network structure characterized by the rewiring probability $\alpha$, the phase diagram shows the reentrant behavior as $\alpha$ is varied, indicating a twofold role of the shortcuts. In $d$-dimensional regular hypercubic lattices, the system also exhibits the reentrant phase transition as $d$ is increased. We identify universality class of the phase transition and discuss the proper mean-field limit of the system.Comment: 8 pages, 7 figures, Phys. Rev. E (in press

Outcomes of endovascular treatment for aortic pseudoaneurysm in Behcet's disease

ObjectiveTo evaluate the effectiveness of endovascular stent grafting for surgical management of aortic pseudoaneurysm in patients with Behcet's disease (BD).MethodsWe present a single-institution retrospective cohort of patients with aortic pseudoaneurysm and BD treated with aortic stent grafting. Computed tomography imaging was obtained preoperatively in all patients and once within 2 weeks postoperatively, and then annually. Clinical follow-up and erythrocyte sedimentation rate were used to follow BD activity. Immunosuppressant therapy was instituted prior to endovascular treatment unless a contraindication existed.ResultsFrom 1998 to 2012, 10 patients (eight male, two female; median age, 39) with BD and aortic pseudoaneurysm were treated with endovascular stent grafting at this institution. Ninety percent of these patients received immunosuppressive therapy before and after surgical treatment. The median follow-up period was 57 months (interquartile range, 43-72). The locations of the 12 pseudoaneurysms treated in this cohort were infrarenal abdominal aorta (seven), descending thoracic aorta (four), and aortic arch (one). Median pseudoaneurysm size was 4.5 cm (interquartile range, 3.4-5.9). At long-term follow-up, complete resolution of the aortic pseudoaneurysm was noted in all patients. No endoleaks occurred. Newly developed pseudoaneurysm at the distal margin of the stent graft was noted in one patient 17 months after the stent graft procedure. One patient required a subsequent stent graft placement for an expanding pseudoaneurysm of the subclavian artery. No patient deaths occurred during the follow-up period.ConclusionsEndovascular treatment of aortic pseudoaneurysm with stent-grafting in patients with BD is safe and effective with long-term durability

Comparative Interactomes of VRK1 and VRK3 with Their Distinct Roles in the Cell Cycle of Liver Cancer

Vaccinia-related kinase 1 (VRK1) and VRK3 are members of the VRK family of serine/threonine kinases and are principally localized in the nucleus. Despite the crucial roles of VRK1/VRK3 in physiology and disease, the molecular and functional interactions of VRK1/VRK3 are poorly understood. Here, we identified over 200 unreported VRK1/VRK3-interacting candidate proteins by affinity purification and LC-MS/MS. The networks of VRK1 and VRK3 interactomes were found to be associated with important biological processes such as the cell cycle, DNA repair, chromatin assembly, and RNA processing. Interactions of interacting proteins with VRK1/VRK3 were confirmed by biochemical assays. We also found that phosphorylations of XRCC5 were regulated by both VRK1/VRK3, and that of CCNB1 was regulated by VRK3. In liver cancer cells and tissues, VRK1/VRK3 were highly upregulated and its depletion affected cell cycle progression in the different phases. VRK3 seemed to affect S phase progression and G2 or M phase entry and exit, whereas VRK1 affects G1/S transition in the liver cancer, which could be explained by different interacting candidate proteins. Thus, this study not only provides a resource for investigating the unidentified functions of VRK1/VRK3, but also an insight into the regulatory roles of VRK1/VRK3 in biological processes.11Ysciescopuskc

Gene silencing in HIV-1 latency by polycomb repressive group

<p>Abstract</p> <p>Background</p> <p>The persistence of latently Human immunodeficiency virus-1 (HIV-1) infected cellular reservoirs in resting CD4⁺T cells is a major obstacle to HIV-1 eradication. The detailed mechanism of HIV-1 latency remains unclear. We investigated histones and their post-translational modification associated with HIV-1 latency in novel HIV-1 latently infected cell lines established previously, NCHA cells.</p> <p>Methods</p> <p>To examine histones and their modification linked with HIV-1 latency, the expression profiles for core histone proteins and histone deacetylases (HDACs) in NCHA cells were characterized by RT-PCR, ELISA, and western blot. The levels of histone acetylation and methylation at histone H3 Lys⁹(H3K9) and Lys²⁷(H3K27) in HIV-1 latently infected cells were analyzed by western blot and chromatin immunoprecipitation-sequencing (ChIP-seq).</p> <p>Results</p> <p>The expression levels for four core histone proteins (H2A, H2B, H3 and H4) and HDACs (HDAC1-8) in NCHA cells were not significantly different from those in their parental cells. Histone H3K9 and H3K27 acetylations in NCHA cells showed no difference in parental and NCHA cells, whereas the levels of di- and tri-methylation were increased in NCHA cells. The expression of EED which is a component of polycomb repressive complex 2 (PRC2), and BMI1 and RING2 which are constituents of PRC1, were upregulated in NCHA cells. In addition, more ubiquitylation at histone H2A was detected in NCHA cells.</p> <p>Conclusions</p> <p>Our results suggest that tri-methylation of histone H3K27 and H2A ubiquitylation via polycomb group protein may play a crucial role in epigenetic silencing accounting for HIV-1 latency in NCHA cells.</p

Coxiella burnetii in Bulk Tank Milk Samples, United States

Dairy cattle are a primary reservoir of Coxiella burnetii, which causes Q fever. However, no recent nationwide studies have assessed the prevalence and risks of Q fever in dairy cattle. We report ≥94% prevalence in samples of bulk tank milk from U.S. dairy herds tested during the past 3 years