Factors influencing mobility in community-dwelling older adults during the early COVID-19 pandemic: a cross-sectional study

Background In older adults, mobility is important for maintaining their independence and quality of life, and it influences their physical, cognitive, and social health. This study aimed to identify the physical and psychosocial factors that affected the mobility of community-dwelling older adults, aged 65 years or older, who were socially isolated during the coronavirus disease 2019 (COVID-19) pandemic due to stay-at-home policies. Methods The participants in this study were 214 community-dwelling older adults in Korea, and a cross-sectional survey was conducted from December 2020 to January 2021. Variables included participants general characteristics, mobility, sitting time, depression, social support, and cognitive function. Results Multiple linear regression analysis showed that the factors influencing older adults mobility during the COVID-19 pandemic were depression (β=-0.29, p < .001), age (65–74 years old) (β = 0.19, p = .002), a lower level of education (β=-0.17, p = .006), two or more comorbidities (β=-0.18, p = .001), sitting time (β=-0.17, p = .004), and the ability to drive a vehicle (β = 0.14, p = .017). Conclusions Home healthcare interventions are needed to limit psychosocial issues and improve mobility for older adults who had limited mobility during the COVID-19 pandemic.This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (No. HI20C0482) and was also supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. RS-2023-00214295)

CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans

Due to its ease of genetic manipulation and transparency, Caenorhabditis elegans (C. elegans) has become a preferred model system to study gene function by microscopy. The use of Aequorea victoria green fluorescent protein (GFP) fused to proteins or targeting sequences of interest, further expanded upon the utility of C. elegans by labeling subcellular structures, which enables following their disposition during development or in the presence of genetic mutations. Fluorescent proteins with excitation and emission spectra different from that of GFP accelerated the use of multifluorophore imaging in real time. We have expanded the repertoire of fluorescent proteins for use in C. elegans by developing a codon-optimized version of Orange2 (CemOrange2). Proteins or targeting motifs fused to CemOrange2 were distinguishable from the more common fluorophores used in the nematode; such as GFP, YFP, and mKate2. We generated a panel of CemOrange2 fusion constructs, and confirmed they were targeted to their correct subcellular addresses by colocalization with independent markers. To demonstrate the potential usefulness of this new panel of fluorescent protein markers, we showed that CemOrange2 fusion proteins could be used to: 1) monitor biological pathways, 2) multiplex with other fluorescent proteins to determine colocalization and 3) gain phenotypic knowledge of a human ABCA3 orthologue, ABT-4, trafficking variant in the C. elegans model organism

In vivo self-degradable graphene nanomedicine operated by DNAzyme and photo-switch for controlled anti-cancer therapy

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You are my everything

242 hlm. ; 19 cm

Dual Stimuli-responsive Nanoconstruct Consisting of Andrographolide-loaded Polymerized Phenylboronic Acid

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Andrographolide-loaded Polymerized Phenylboronic Acid Nanoconstruct for Dual Stimuli-Responsive Chemotherapy

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In Vivo Self-degradable Graphene Nanomedicine Operated by DNAzyme and Photo-switch for Controlled Anticancer Therapy

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Catalytic pgraphene nanomedicine opereated by phto-switch for controlled anticancer therapy and DNAzyme-mediated self-degradation

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Dual Stimuli-responsive Nanoconstruct Consisting of Andrographolide-loaded Polymerized Phenylboronic Acid

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