Sedimentary and structural evolution of the Eastern South Korea Plateau (ESKP), East Sea (Japan Sea)

The East Sea (Japan Sea) is a semi-enclosed back-arc basin that is thought to preserve a significant record of tectonic evolution and paleo-climatic changes of Eastern Asia during the Neogene. We use here 2-D regional multi-channel seismic reflection profiles and borehole data from Expedition 346 of the Integrated Ocean Drilling Program (IODP) to provide new constraints on the geological history of the Eastern South Korea Plateau (ESKP). The ESKP represents a structurally-complex basement high in the southwestern East Sea which formed during rifting of the back-arc basin. Our new observations show that the ESKP is composed of numerous horsts and grabens controlled by NE-trending normal faults. The acoustic basement is blanketed by Oligocene to recent sediments that have preferentially accumulated in topographic lows (up to 1.5 km thick) and have been cored during Expedition 346 at Site U1430 close to the southern margin of the ESKP. Seismic profiles in the ESKP reveal three units separated by regional unconformities. These seismic units closely correspond to IODP lithostratigraphic units defined at Site U1430, where biostratigraphic data can be used to constrain the timing of three main evolutionary stages of the ESKP. Stage 1 was related to rifting in the late Oligocene and middle Miocene, terminated by a regional uplift leading to an erosional phase in the middle Miocene. Stage 2 was associated with subsidence in the middle and late Miocene and uplift and accompanying erosion or non-deposition in the latest late Miocene. Stage 3 (Pliocene to present) recorded overall uniform hemipelagic-pelagic subsidence of the ESKP with short-lived tectonically-induced uplifts in the late middle Miocene and latest Miocene-early Pliocene. The three stages of evolution of the ESKP closely correlate to sedimentary changes since the Oligocene and suggest a direct control of regional/local tectonics on sedimentation patterns in the southwestern East Sea, with secondary influence of regional climatic and paleo-oceanographic processes

Freshwater and Terrestrial Algae from Ny-Ålesund and Blomstrandhalvøya Island (Svalbard)

A field survey of algae and cyanobacteria from terrestrial and freshwater habitats in the vicinity of Ny-Ålesund and on Blomstrandhalvøya Island (Svalbard) was performed in June 2009, and results were compared with data from our fieldwork in June 2006. In total, we identified 30 taxa belonging to 23 genera from the specimens collected near Ny-Ålesund (26 taxa) and on Blomstrandhalvøya Island (24 taxa). Five species previously unrecorded from this locality are depicted, including astaxanthin-containing Haematococcus sp. collected from Blomstrandhalvøya Island. This is the first report on a Haematococcus species from the High Arctic.Une étude sur le terrain portant sur les algues et les cyanobactéries d’habitats terrestres et dulçaquicoles dans les environs de Ny-Ålesund et de l’île Blomstrandhalvøya (Svalbard) a été réalisée en juin 2009, et les résultats ont été comparés aux données de notre travail sur le terrain effectué en juin 2006. En tout, nous avons identifié 30 taxons appartenant à 23 genres à partir de spécimens prélevés près de Ny-Ålesund (26 taxons) et de Blomstrandhalvøya (24 taxons). Cinq espèces qui n’avaient jamais été répertoriées dans cette localité sont illustrées, dont l’Haematococcus sp. contenant de l’astaxanthine recueillie à l’île Blomstrandhalvøya. Il s’agit de la première fois que l’espèce Haematococcus a été signalée dans l’Extrême-Arctique

Endoscopic Submucosal Dissection of Gastric Epithelial Neoplasms after Partial Gastrectomy: A Single-Center Experience

Aims. To investigate the feasibility and safety of endoscopic submucosal dissection (ESD) of gastric epithelial neoplasms in the remnant stomach (GEN-RS) after various types of partial gastrectomy. Methods. This study included 29 patients (31 lesions) who underwent ESD for GEN-RS between March 2006 and August 2016. Clinicopathologic data were retrieved retrospectively to assess the therapeutic ESD outcomes, including en bloc and complete resection rates and procedure-related adverse events. Results. The en bloc, complete, and curative resection rates were 90%, 77%, and 71%, respectively. The types of previous gastrectomy, tumor size, macroscopic type, and tumor histology were not associated with incomplete resection. Only tumors involving the suture lines from the prior partial gastrectomy were significantly associated with incomplete resection. The procedure-related bleeding and perforation rates were 6% and 3%, respectively; none of the adverse events required surgical intervention. During a median follow-up period of 25 months (range, 6–58 months), there was no recurrence in any case. Conclusions. ESD is a safe and feasible treatment for GEN-RS regardless of the previous gastrectomy type. However, the complete resection rate decreases for lesions involving the suture lines

Macroalgal eukaryotic microbiome composition indicates novel phylogenetic diversity and broad host spectrum of oomycete pathogens

Peer reviewe

Synthesis of nanoporous Mo:BiVO4 thin film photoanodes using the ultrasonic spray technique for visible-light water splitting

The use of bismuth vanadate (BiVO4) scheelite structures for converting solar energy into fuels and chemicals for fast growth in lab to industrial scale for large-area modules is a key challenge for further development. Herein, we demonstrate a new ultrasonic spray technique as a scalable and versatile coating technique for coating pristine and doped nanoporous BiVO4 thin film photoanodes directly on FTO-coated glass substrates for water splitting under visible irradiation. The successful Mo doping in BiVO4 lattice was confirmed by various characterization techniques such as XRD, Raman, EDS and XPS. The Mo:BiVO4 photoelectrode showed excellent performance with higher stability as compared to pristine BiVO4 samples

Exploration of New Electroacupuncture Needle Material

Background. Electro Acupuncture (EA) uses the acupuncture needle as an electrode to apply low-frequency stimulation. For its safe operation, it is essential to prevent any corrosion of the acupuncture needle. Objective. The aim of this study is to find an available material and determine the possibility of producing a standard EA needle that is biocompatible. Methods. Biocompatibility was tested by an MTT assay and cytotoxicity testing. Corrosion was observed with a scanning electron microscope (SEM) after 0.5 mA, 60 min stimulation. The straightness was measured using a gap length of 100 mm, and tensile testing was performed by imposing a maximum tensile load. Results. Phosphor bronze, Ni coated SS304, were deemed inappropriate materials because of mild-to-moderate cytotoxicity and corrosion. Ti-6Al-4V and SS316 showed no cytotoxicity or corrosion. Ti-6Al-4V has a 70 times higher cost and 2.5 times lower conductivity than SS316. The results of both straightness and tensile testing confirmed that SS316 can be manufactured as a standard product. Conclusion. As a result, we confirmed that SS316 can be used a new EA electrode material. We hope that a further study of the maximum capacity of low-frequency stimulation using an SS316 for safe operation

FAM167A is a key molecule to induce BCR-ABL-independent TKI resistance in CML via noncanonical NF-κB signaling activation

Abstract Background BCR-ABL-independent drug resistance is a barrier to curative treatment of chronic myeloid leukemia (CML). However, the molecular pathways underlying BCR-ABL-independent tyrosine kinase inhibitor (TKI) resistance remain unclear. Methods In silico bioinformatic analysis was performed to identify the most active transcription factor and its inducer that contribute to BCR-ABL-independent TKI resistance. Tandem mass spectrometry analysis was performed to identify the receptor for the noncanonical NF-κB activator FAM167A. In vitro and in vivo mouse experiments revealed detailed molecular insights into the functional role of the FAM167A-desmoglein-1 (DSG1) axis in BCL-ABL-independent TKI resistance. CML cells derived from CML patients were analyzed using quantitative reverse transcription PCR and flow cytometry. Results We found that NF-κB had the greatest effect on differential gene expression of BCR-ABL-independent TKI-resistant CML cells. Moreover, we found that the previously uncharacterized protein FAM167A activates the noncanonical NF-κB pathway and induces BCR-ABL-independent TKI resistance. Molecular analyses revealed that FAM167A activates the noncanonical NF-κB pathway by binding to the cell adhesion protein DSG1 to upregulate NF-κB-inducing kinase (NIK) by blocking its ubiquitination. Neutralization of FAM167A in a mouse tumor model reduced noncanonical NF-κB activity and restored sensitivity of cells to TKIs. Furthermore, FAM167A and surface DSG1 levels were highly upregulated in CD34+ CML cells from patients with BCR-ABL-independent TKI-resistant disease. Conclusions These results reveal that FAM167A acts as an essential factor for BCR-ABL-independent TKI resistance in CML by activating the noncanonical NF-κB pathway. In addition, FAM167A may serve as an important target and biomarker for BCR-ABL-independent TKI resistance

Anticancer Efficacy of Cordyceps militaris

Cordyceps militaris is used widely as a traditional medicine in East Asia. Although a few studies have attempted to elucidate the anticancer activities of C. militaris, the precise mechanism of C. militaris therapeutic effects is not fully understood. We examined the anticancer activities of C. militaris ethanolic extract (Cm-EE) and its cellular and molecular mechanisms. For this purpose, a xenograft mouse model bearing murine T cell lymphoma (RMA) cell-derived cancers was established to investigate in vivo anticancer mechanisms. MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay, immunoblotting analysis, and flow cytometric assay were employed to check in vitro cytotoxicity, molecular targets, and proapoptotic action of Cm-EE. Interestingly, cancer sizes and mass were reduced in a C. militaris-administered group. Levels of the phosphorylated forms of p85 and AKT were clearly decreased in the group administered with Cm-EE. This result indicated that levels of phosphoglycogen synthase kinase 3β (p-GSK3β) and cleaved caspase-3 were increased with orally administered Cm-EE. In addition, Cm-EE directly inhibited the viability of cultured RMA cells and C6 glioma cells. The number of proapoptotic cells was significantly increased in a Cm-EE treated group compared with a control group. Our results suggested that C. militaris might be able to inhibit cancer growth through regulation of p85/AKT-dependent or GSK3β-related caspase-3-dependent apoptosis