Headaches during pregnancy and the risk of subsequent stroke

Background Primary headache disorder is a known risk factor for stroke in women and usually improves during the first trimester of pregnancy. However, despite this, some women develop headaches during pregnancy (G-HA), and the effect of this headache on subsequent stroke is unknown. In this study, we evaluated the association between G-HA and stroke after delivery in women. Methods Based on the Korean National Health Insurance Service database, we included women hospitalized for delivery between 2012 and 2013. G-HA was defined as a headache diagnosed during pregnancy. Primary outcome was any stroke that occurred during the observational periods from delivery to December 31, 2020. All diseases were identified based on data registered in the database using the International Classification of Disease-10th Revision-Clinical Modification codes. Results Of 906,187 pregnant women, G-HA was found in 56,813 (6.3%). During the observational periods, the G-HA ( +) group had a significantly higher risk of any stroke [adjusted hazard ratio (aHR) = 1.59, 95% confidence interval (CI): 1.30–1.95], ischemic stroke (aHR = 1.50, 95% CI: 1.12–2.01), hemorrhagic stroke (aHR = 1.63, 95% CI: 1.23–2.15), and intracerebral hemorrhage (aHR = 1.63, 95% CI: 1.19–2.23) than the G-HA (-) group. When analyzed considering the interaction with history of headache disorder, G-HA showed a significant association with hemorrhagic stroke, but lost its effect on ischemic stroke. Conclusions We demonstrated that G-HA was associated with subsequent stroke occurrence after delivery. However, the relationship between G-HA and ischemic stroke is mitigated by a history of pre-pregnancy headache disorder.This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science & ICT (NRF-2020R1C1C1013304). The funding organization had no role in the design, conduct or preparation of this report

Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation in Young Children with Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System

The feasibility and effectiveness of tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT) were evaluated in children younger than 3 yr of age with atypical teratoid/rhabdoid tumors (ATRT). Tandem HDCT/autoSCT was administered following six cycles of induction chemotherapy. Radiotherapy (RT) was administered if the tumor relapsed or progressed, otherwise, it was administered after 3 yr of age. Tumors relapsed or progressed during induction chemotherapy in 5 of 9 patients enrolled; 3 of these 5 received tandem HDCT/autoSCT as a salvage treatment. One patient died from sepsis during induction chemotherapy. The remaining 3 patients proceeded to tandem HDCT/autoSCT; however, 2 of these patients showed tumor relapse/progression after tandem HDCT/autoSCT. All 7 relapses/progressions occurred at primary sites even in patients with leptomeningeal seeding. Toxicities during tandem HDCT/autoSCT were manageable. A total of 5 patients were alive with a median follow-up of 20 (range 16-70) months from diagnosis. Four of 5 patients who received RT after relapse/progression are alive. The probability of overall survival at 3 yr from diagnosis was 53.3% ± 17.3%. Our tandem HDCT/autoSCT is feasible; however, early administration of RT prior to tandem HDCT/autoSCT should be considered to improve the outcome after tandem HDCT/autoSCT

Extinction-free Census of AGNs in the AKARI/IRC North Ecliptic Pole Field from 23-band Infrared Photometry from Space Telescopes

In order to understand the interaction between the central black hole and the whole galaxy or their co-evolution history along with cosmic time, a complete census of active galactic nuclei (AGN) is crucial. However, AGNs are often missed in optical, UV and soft X-ray observations since they could be obscured by gas and dust. A mid-infrared (mid-IR) survey supported by multiwavelength data is one of the best ways to find obscured AGN activities because it suffers less from extinction. Previous large IR photometric surveys, e.g., WISE and Spitzer, have gaps between the mid-IR filters. Therefore, star forming galaxy (SFG)-AGN diagnostics in the mid-IR were limited. The AKARI satellite has a unique continuous 9-band filter coverage in the near to mid-IR wavelengths. In this work, we take advantage of the state-of-the-art spectral energy distribution (SED) modelling software, CIGALE, to find AGNs in mid-IR. We found 126 AGNs in the NEP-Wide field with this method. We also investigate the energy released from the AGN as a fraction of the total IR luminosity of a galaxy. We found that the AGN contribution is larger at higher redshifts for a given IR luminosity. With the upcoming deep IR surveys, e.g., JWST, we expect to find more AGNs with our method

Impaired Design Fluency Is a Marker of Pathological Cognitive Aging; Results from the Korean Longitudinal Study on Health and Aging

ObjectiveaaWe investigated neuropsychological markers that can be used to discriminate pathological cognitive aging from normal cognitive aging. MethodsaaWe administered frontal lobe function tests including the Wisconsin Card Sorting Test (WCST), digit span test, lexical fluency test, fixed condition design fluency test, and Trail Making Test B (TMT-B) to 92 individuals with pathological cognitive aging (PCA) and 222 individuals with normal cognitive aging (NCA). We examined the main effects of participants ’ diagnoses (PCA, NCA) and age (65-69 years old, 70-74 years old and 75 years old or over) on their test performance using multivariate analysis of variance. ResultsaaThe main effects of both the diagnosis (F=2.860, p=0.002) and the age group (F=2.484, p<0.001) were significant. The PCA group showed lower performance on the backward digit span test (F=14.306, p<0.001), fixed condition design fluency test (F=8.347, p=0.004) and also exhibited perseverative errors in the WCST (F=4.19, p=0.042) compared with the NCA group. The main effect of the diagnosis on the backward digit span test and the fixed condition design fluency test remained significant after Bonferroni correction

Generation of homogeneous midbrain organoids with in vivo-like cellular composition facilitates neurotoxin-based Parkinson\u27s disease modeling

Recent studies have demonstrated the generation of midbrain-like organoids (MOs) from human pluripotent stem cells. However, the low efficiency of MO generation and the relatively immature and heterogeneous structures of the MOs hinder the translation of these organoids from the bench to the clinic. Here we describe the robust generation of MOs with homogeneous distribution of midbrain dopaminergic (mDA) neurons. Our MOs contain not only mDA neurons but also other neuronal subtypes as well as functional glial cells including astrocytes and oligodendrocytes. Furthermore, our MOs exhibit mDA neuron-specific cell death upon treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, indicating that MOs could be a proper human model system for studying the in vivo pathology of Parkinson\u27s disease (PD). Our optimized conditions for producing homogeneous and mature MOs might provide an advanced patient-specific platform for in vitro disease modeling as well as for drug screening for PD

Identification of <i>AKARI</i> infrared sources by the Deep HSC Optical Survey: construction of a new band-merged catalogue in the North Ecliptic Pole Wide field

The North Ecliptic Pole field is a natural deep-field location for many satellite observations. It has been targeted many times since it was surveyed by the AKARI space telescope with its unique wavelength coverage from the near- to mid-infrared (mid-IR). Many follow-up observations have been carried out, making this field one of the most frequently observed areas with a variety of facilities, accumulating abundant panchromatic data from the X-ray to the radio wavelength range. Recently, a deep optical survey with the Hyper Suprime-Cam (HSC) at the Subaru telescope covered the NEP-Wide (NEPW) field, which enabled us to identify faint sources in the near- and mid-IR bands, and to improve the photometric redshift (photo-z) estimation. In this work, we present newly identified AKARI sources by the HSC survey, along with multiband photometry for 91 861 AKARI sources observed over the NEPW field. We release a new band-merged catalogue combining various photometric data from the GALEX UV to submillimetre (sub-mm) bands (e.g. Herschel/SPIRE, JCMT/SCUBA-2). About ∼20 000 AKARI sources are newly matched to the HSC data, most of which seem to be faint galaxies in the near- to mid-infrared AKARI bands. This catalogue is motivating a variety of current research, and will be increasingly useful as recently launched (eROSITA/ART-XC) and future space missions (such as JWST, Euclid, and SPHEREx) plan to take deep observations in the NEP field

Optically detected galaxy cluster candidates in the <i>AKARI</i> North Ecliptic Pole field based on photometric redshift from the Subaru Hyper Suprime-Cam

Galaxy clusters provide an excellent probe in various research fields in astrophysics and cosmology. However, the number of galaxy clusters detected so far in the AKARI North Ecliptic Pole (NEP) field is limited. In this work, we provide galaxy cluster candidates in the AKARI NEP field with the minimum requisites based only on the coordinates and photometric redshift (photo-z) of galaxies. We used galaxies detected in five optical bands (g, r, i, z, and Y) by the Subaru Hyper Suprime-Cam (HSC), with additional data from the u band obtained from the Canada-France-Hawaii Telescope (CFHT) MegaPrime/MegaCam, and from the IRAC1 and IRAC2 bands from the Spitzer space telescope for photo-z estimation. We calculated the local density around every galaxy using the 10th-nearest neighbourhood. Cluster candidates were determined by applying the friends-of-friends algorithm to over-densities. A total of 88 cluster candidates containing 4390 member galaxies below redshift 1.1 in 5.4 deg2 were identified. The reliability of our method was examined through false-detection tests, redshift-uncertainty tests, and applications on the Cosmic Evolution Survey (COSMOS) data, giving false-detection rates of 0.01 to 0.05 and a recovery rate of 0.9 at high richness. Three X-ray clusters previously observed by ROSAT and Chandra were recovered. The cluster galaxies show a higher stellar mass and lower star formation rate compared with the field galaxies in two-sample Z-tests. These cluster candidates are useful for environmental studies of galaxy evolution and future astronomical surveys in the NEP, where AKARI has performed unique nine-band mid-infrared photometry for tens of thousands of galaxies

Environmental effects on AGN activity via extinction-free mid-infrared census

How does the environment affect active galactic nucleus (AGN) activity? We investigated this question in an extinction-free way, by selecting 1120 infrared galaxies in the AKARI North Ecliptic Pole Wide field at redshift z ≤ 1.2. A unique feature of the AKARI satellite is its continuous 9-band infrared (IR) filter coverage, providing us with an unprecedentedly large sample of IR spectral energy distributions (SEDs) of galaxies. By taking advantage of this, for the first time, we explored the AGN activity derived from SED modelling as a function of redshift, luminosity, and environment. We quantified AGN activity in two ways: AGN contribution fraction (ratio of AGN luminosity to the total IR luminosity), and AGN number fraction (ratio of number of AGNs to the total galaxy sample). We found that galaxy environment (normalised local density) does not greatly affect either definitions of AGN activity of our IRG/LIRG samples (log LTIR ≤ 12). However, we found a different behavior for ULIRGs (log LTIR &amp;gt; 12). At our highest redshift bin (0.7 ≲ z ≲ 1.2), AGN activity increases with denser environments, but at the intermediate redshift bin (0.3 ≲ z ≲ 0.7), the opposite is observed. These results may hint at a different physical mechanism for ULIRGs. The trends are not statistically significant (p ≥ 0.060 at the intermediate redshift bin, and p ≥ 0.139 at the highest redshift bin). Possible different behavior of ULIRGs is a key direction to explore further with future space missions (e.g., JWST, Euclid, SPHEREx)