1,228 research outputs found

    Measuring Technological Change - Concept, Methods, and Implications

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    INTEGRAL TRANSFORMS OF FUNCTIONALS IN \u3ci\u3eL\u3c/i\u3e2(\u3ci\u3eC\u3c/i\u3e0[0, \u3ci\u3eT\u3c/i\u3e])

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    In this paper we give a necessary and sufficient condition that a functional F(x) in L2(C0[0, T]) has an integral transform Fα,βF(x) which also belongs to L2(C0[0, T])

    Cells Attachment Property of PVA Hydrogel Nanofibers Incorporating Hyaluronic Acid for Tissue Engineering

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    In this work, we report the fabrication and cell affinity studies of the poly(vinyl alcohol) (PVA)/hyaluronic acid (HA) cross-linked nanofibers via electrospinning and post cross-linking. FT-IR and TGA analysis demonstrate that HA is not influenced by acid environment such as HCl vapor during cross-linking, and well incorporated into PVA nanofibers. Swelling behavior and cell adhesion of the PVA/HA hydrogel nanofibers are investigated and compared with pure PVA hydrogel nanofibers. It is expected that the nanofibrous PVA/HA hydrogel fibers could be a promising scaffold for cell culture and tissue engineering applications.ArticleJournal of Biomaterials and Nanobiotechnology. 2:353-360 (2011)journal articl

    Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery

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    In this work, novel nanostructured core-shell poly (ethylene glycol) (PEG)-polyhedral oligosilsesquioxane (POSS) nanoparticles were used to encapsulate insulin as new drug delivery carriers. The morphologies, particle size and ? potential of th e pure nanostructured core-shell PEG-POSS and th e corresponding insulin-load ed PEG-POSS nanopar-ticles were investigated by transmission electron microscopy (TEM) and laser diffraction particle sizer. TEM analysis demonstrated that pure and insulin-loaded self-assembled PEG-POSS nanoparticles were of spherical shape with core-shell nanostructure, and were well-dispersed and uniform in size distribution. Insulin release test showed that in-sulin was well-protected in side PEG-POSS nanoparticles at gastric pH for 2 hrs, and was released at intestinal pH (pH 6 - 7) where the absorption and activation of the drug are necessary. We therefore believe that such nanostructured PEG-POSS nanoparticles could be useful as a potential carrier for insulin drug delivery systems.ArticleJournal of Biomaterials and Nanobiotechnology. 2:201-206 (2011)journal articl
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