HIBISCUS: Hydroxychloroquine for the secondary prevention of thrombotic and obstetrical events in primary antiphospholipid syndrome

The relapse rate in antiphospholipid syndrome (APS) remains high, i.e. around 20%-21% at 5 years in thrombotic APS and 20-28% in obstetrical APS [2, 3]. Hydroxychloroquine (HCQ) appears as an additional therapy, as it possesses immunomodulatory and anti-thrombotic various effects [4-16]. Our group recently obtained the orphan designation of HCQ in antiphospholipid syndrome by the European Medicine Agency. Furthermore, the leaders of the project made the proposal of an international project, HIBISCUS, about the use of Hydroxychloroquine in secondary prevention of obstetrical and thrombotic events in primary APS. This study has been launched in several countries and at now, 53 centers from 16 countries participate to this international trial. This trial consists in two parts: a retrospective and a prospective study. The French part of the trial in thrombosis has been granted by the French Minister of Health in December 2015 (the academic trial independent of the pharmaceutical industry PHRC N PAPIRUS) and is coordinated by one of the members of the leading consortium of HIBISCUS

2-(2,6-Di-Tert-Butylphenoxy)-2',4,4,4',4',6,6,6',6'-Nonachloro-2,2'-Bi(Cyclotri-Lambda-5-Phosphazene)

The title compound consists of the bulky 2,6-di-tert-butylphenoxy group and two phosphazene rings joined by a P-P bond [2.193 (2) angstrom]. The bulky group plays a predominant role in the distortion of the molecule as a whole. This distortion results in deviations of the benzene and phosphazene rings from planarity and twists the rings with respect to each other. In monocyclophosphazenes, the endocyclic angles about the P atom decrease while the exocyclic angles increase. This is in contrast to the behaviour of title compound (a bicyclophosphazene) in which the exo- and endocyclic angles about the P atoms both decrease on substitution.Wo

Insect pests determined in fresh onion fields in Izmir province [İzmir ilinde taze sogan tarlalarínda saptanan böcek türleri]

In this study, insect pests of fresh onion cultivated areas of Izmir province have been determined. For this purpose, 155 onion fields have been observed in Bayíndír, Çeşme, Kemalpaşa, Menemen, Tire and Torbalí districts in 2006, periodically. In the following years, 164 onion fields have been observed in Bayíndír, Bornova, Menemen and Tire in 2007-2008. Six families, seven species and four genera from Hemiptera, seven species from Thripidae, two species from Phlaeothripidae and four species from Aeolothripidae of Thysanoptera have been found throughout the study. Two families, six species from Coleoptera and one species from Neuroptera order have been determined. In addition, one species and the species from 10 families of Diptera (Chloropidae, Chironomidae, Drosophilidae, Empididae, Mycetophilidae, Muscidae, Phoridae, Psichodidae, Sepsidaea, Sciaridae) have been found. As a result of study, Thrips tabaci Lindeman (Thysanoptera: Thripidae) and Bactericera tremblayi Wagner (Hemiptera: Triozidae) have been considered as the key pest and the second major pest, respectively. The most important species among dipterans has been determined as Delia platura Meigen of Anthomyiidae. Aeolothrips intermedius Bagnall (Thysanoptera: Aeolothripidae) has been determined as the most abundant natural enemy. Orius spp. (Hemiptera: Anthocoridae), Nabis spp. (Hemiptera: Nabidae), Coccinella septempunctata L. (Coleoptera: Coccinellidae), Chrysoperla carnea Steph. (Neuroptera: Chrysopidae) were determined rarely as natural enemies. In the study abundance of the natural enemies were found rarely because of intensive and non specific uses of pesticides

2-(2,6-Di-Tert-Butyl-4-Methylphenoxy)-2,4,4,6,6,8,8-Heptachlorocyclo-2 Lambda(5),4 Lambda(5),6 Lambda(5),8 Lambda(5)-Tetraphosphazatetraene

The title compound, C15H23Cl7N4OP4, consists Of a saddle-shaped cyclic tetrameric phosphazene ring and a bulky 2,6-di-tert-butyl-4-methylphenoxy side group. The bulky group substituent is instrumental in determining the molecular shape. The exo- and endocyclic angles about the P atoms both decrease on substitution whereas the P-N-P angles increase.WoSScopu

Schiff-Bases and Their Complexes With Metal-Ions .1. 2-Hydroxy-N-N-Propyl-1-Naphthaldimine (1) and Bis(2-Hydroxy-Kappa-O-N-N-Propyl-1-Naphthaldiminato-Kappa-N)Nickel(Ii) (2)

(1) [systematic name: 1-(2-aza-1-penten-1-yl)-2-naphth-ol], C14H15NO, is a bidentate ligand used for the preparation of (2), [Ni(C14H14NO)(2)]. It has an unexpectedly short C2-O [1.254(8) Angstrom] bond length, and a H ... N intramolecular close contact [2.403(7) Angstrom]. In (2), the asymmetric unit comprises two half-complexes. The coordination of the Ni-II ions is square planar with bond angles between 88.0(1) and 92.0(1)degrees. The Ni-O distances are 1.826(2) and 1.913(2) Angstrom and the Ni-N distances are 1.827(2) and 1.911(2) Angstrom A in the two complexes.Wo