2 research outputs found
RHOA and mDia1 promotes apoptosis of breast cancer cells via a high dose of doxorubicin treatment
Transforming RhoA proteins (RHOA) and their downstream Diaphanous homolog 1 proteins (DIAPH1) or mDia1 participate in the regulation of actin cytoskeleton which plays critical role in cells, i.e., morphologic changes and apoptosis
Effect of Equal Daily Doses Achieved by Different Power Densities of Low-Level Laser Therapy at 635ânm on Open Skin Wound Healing in Normal and Diabetic Rats
Background and Objective. Despite the fact that the molecular mechanism of low-level laser therapy (LLLT) is not yet known, the exploitation of phototherapy in clinical medicine and surgery is of great interest. The present study investigates the effects of LLLT on open skin wound healing in normal and diabetic rats. Materials and Methods. Four round full-thickness skin wounds on dorsum were performed in male adult nondiabetic (n=24) and diabetic (n=24) SpragueâDawley rats. AlGaInP (635ânm, wavelength; 5âJ/cm2, daily dose) was used to deliver power densities of 1, 5, and 15âmW/cm2 three times daily until euthanasia. Results. PMNL infiltration was lower in the irradiated groups (15âmW/cm2). The synthesis and organisation of collagen fibres were consecutively enhanced in the 5âmW/cm2 and 15âmW/cm2 groups compared to the others in nondiabetic rats. In the diabetic group the only significant difference was recorded in the ratio PMNL/Ma at 15âmW/cm2. A significant difference in the number of newly formed capillaries in the irradiated group (5, 15âmW/cm2) was recorded on day six after injury compared to the control group. Conclusion. LLLT confers a protective effect against excessive inflammatory tissue response; it stimulates neovascularization and the early formation of collagen fibres