Two C21-steroidal glycosides isolated from Cynanchum stauntoi

Studies on the roots of Cynanchum stauntoi led to the isolation of two C21-steroidal glycosides, formally named stauntosides A and B. Their structures were elucidated on the basis of spectroscopic evidence, especially that from analysis of 2D-NMR spectra. They were found to possess an unusual skeleton and were identified as stauntogenin 3-O-α-L-diginopyranosyl-(1-4)- β-Lcymaropyranosyl-(1-4)-β-D-digitoxopyranosyl-(1-4)-β-D-thevetopyranoside and stauntogenin 3-O-α-L-cymaropyranosyl-(1-4)-β-D-digitoxopyranosyl-(1-4)- β-D-3-demethyl-2-deoxy-thevetopyranoside.link_to_subscribed_fulltex

Isolation and structural elucidation of two new glycosides from sage (Salvia officinalis L.)

Six compounds, 1-O-(2,3,4-trihydroxy-3-methyl)butyl-6-O-feruloyl-β-D- glucopyranoside, ethyl β-D-glucopyranosyl tuberonate, p-hydroxybenzoic acid, (-)-hydroxyjasmonic acid, caffeic acid, and 4-hydroxyacetophenone 4-O-[5-O- (3,5-dimethoxy-4-hydroxybenzoy])-β-D-apiofrunosy]]-(1→2)-β-D-glu- copyranoside, were isolated from the n-butanol-soluble fraction of sage leaf extracts. Their structures were determined by spectral methods (MS, NMR, and 2D-NMR), and their antioxidant activities were measured. Among them, two new glycosides were elucidated. All of these compounds showed DPPH free radical scavenging activity at the concentration of 30 mM, and caffeic acid was the most active compound.link_to_subscribed_fulltex

Acetophenone glycosides from thyme (Thymus vulgaris L.)

Four acetophenone glycosides were isolated from the butanol-soluble fraction of thyme extracts. Their structures were determined by spectral methods (MS, NMR, and 2D-NMR). Among them, two new compounds, 4- hydroxyacetophenone 4-O-[5-O-(3,5-dimethoxy-4-hydroxybenzoyl)-β-D- apiofuranosyl]-(1-2)-β-D-glucopyranoside (1) and 4-hydroxyacetophenone 4-O- [5-O-(4-hydroxybenzoyl)β-D-apiofuranosyl]-(1-2)-β-D-glucopyranoside (2), were determined. Compound 1 showed weak cytotoxicity, inhibiting DNA synthesis of human leukemia cells.link_to_subscribed_fulltex

Furanosesquiterpenoids of Commiphora myrrha

An investigation on the gum exudates of Commiphora myrrha has led to the isolation of six sesquiterpenoids. On the basis of spectroscopic data interpretation, they were determined as two new furanosesquiterpenoids, rel-1S,2S-epoxy-4R-furanogermacr-10(15)-en-6-one (1) and rel-2R-methyl-5S-acetoxy-4R-furanogermacr-1(10)Z-en-6-one (2), and four known furanosesquiterpenoids, rel-3R-methoxy-4S-furanogermacra-1E,10(15)-dien-6-one(3),rel-2R-methoxy-4R- furanogermacr-1(10)E-en-6-one(4),furanogermacra-1(10)Z,4Z-dien-6-one, 1(10)Z,4Z-dien-6-one, and curzerenone [6,7-dihydro-5β-isopropenyl-3,6β-dimethyl-6-vinylbenzofuran- 4(5H)-one]. This is the first report of the relative stereochemistry for the known compounds 3 and 4. Compound 1 exhibited weak cytotoxic activity against a MCF-7 breast tumor cell line in a clonogenic assay, while the other five compounds were inactive in this assay.link_to_subscribed_fulltex

Novel glycosides from noni (Morinda citrifolia)

Three new glycosides were isolated from the fruits of noni (Morinda citrifolia). Their structures were determined to be 6-O-(β-D-glucopyranosyl)-1-O-octanoyl-β-D-glucopyranose (1), 6-O-(β-D-glucopyranosyl)-1-O-hexanoyl-β-D-glucopyranose (2), and 3-methylbut-3-enyl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside (3) using MS and NMR methods.link_to_subscribed_fulltex

Novel trisaccharide fatty acid ester identified from the fruits of Morinda citrifolia (noni)

Two known glycosides and a novel trisaccharide fatty acid ester were isolated from the n-butanolsoluble fraction of the fruits of Morinda citrifolia (noni). Structure determination was carried out by spectral techniques such as MS, IR, NMR, and 2D-NMR. The novel trisaccharide fatty acid ester was elucidated as 2,6-di-O-(β-D-glucopyranosyl)-1-O-octanoyl-β- D-glucopyranose. The known compounds were identified as rutin and asperulosidic acid.link_to_subscribed_fulltex