1,002 research outputs found
Influence of fibers on the dust dislodgement efficiency of bag filters
In recent years non-woven bag filters have been used in waste incinerators for the efficient collection of dust and removal of detrimental gas. However, dust collection efficiency decreases with time until the bag filters are no longer effective. Dust adhering to the fabric is a major determinant of bag filter life. In the present study a flat filter was used to study the relationship between various parameters of a bag filter structure and its dust dislodgement efficiency. The results confirm that fiber linear density, modulus of elasticity, and the form of the fiber cross-section of the felt can each affect the dust collection efficiency of a bag filter. Higher fiber linear density in a bag filter prevents dust from penetrating the filter, and this allows the dust to be more easily dislodged from the filter. Examination of various forms of fiber cross-section indicates that for the same fiber linear density the triangular form is better than the circular form. A lower Young's modulus allows the fiber to bend more easily and prevents the dust from penetrating the filter. Fiber linear density, fiber modulus of elasticity and form of the fiber cross-section are the variables affecting bag filter efficiency.ArticleTEXTILE RESEARCH JOURNAL. 84(7):764-771 (2014)journal articl
Euclidean Distances, soft and spectral Clustering on Weighted Graphs
We define a class of Euclidean distances on weighted graphs, enabling to
perform thermodynamic soft graph clustering. The class can be constructed form
the "raw coordinates" encountered in spectral clustering, and can be extended
by means of higher-dimensional embeddings (Schoenberg transformations).
Geographical flow data, properly conditioned, illustrate the procedure as well
as visualization aspects.Comment: accepted for presentation (and further publication) at the ECML PKDD
2010 conferenc
Ribozyme-mediated inactivation of mutant K-ras oncogene in a colon cancer cell line
Mutation of c-K-ras oncogene is an important step in progression of colon cancer. We used a hammerhead ribozyme (KrasRz) against mutated K-ras gene transcripts (codon 12, GTT) to inactivate mutant K-ras function in the colon cancer cell line SW480, harbouring a mutant K-ras gene. The β-actin promoter-driven KrasRz sequence (pHβ/KrasRz) was introduced into these cells (SW480/KrasRz), and we evaluated its effects on growth of the colon cancer. The gene expression of angiogenesis-related molecules (vascular endothelial growth factor and thrombospondin) was also estimated in SW480/KrasRz. KrasRz specifically and efficiently cleaved the mutant K-ras mRNA but not wild-type mRNA in vitro. SW480/KrasRz showed decreased growth rate under tissue culture conditions (P< 0.01, Dunnett’s test). The xenotransplantability of SW480/KrasRz (XeSW480/KrasRz) was significantly decreased in nude mice (P< 0.05, Fisher’s exact test). Tumour volume of the xenografts XeSW480/KrasRz was significantly smaller than that of XeSW480/DisKrasRz (P< 0.01, Dunnett’s test). Gene expression of VEGF was suppressed in SW480/KrasRz, while TSP1 gene expression was enhanced. The SW480/KrasRz cells showed apoptosis-related features including nuclear condensation and DNA fragmentation. These results suggested that the hammerhead ribozyme-mediated inactivation of the mutated K-ras mRNA induced growth suppression, apoptosis and alteration of angiogenic factor expression. © 2000 Cancer Research Campaig
Development of miracle medicines from sialic acids
Sialic acids are electronegatively charged C9-sugars and are considered to play important roles in higher animals and some microorganisms. Denoting their significance, understanding and exploiting the complexity of the sialic acids has been referred to as the “the third language of life”. In essence, “sialic acid derivatives possess a harmonious shape and good balance between two opposing hydrophilic and hydrophobic parts, meaning that they should display various kinds of potentially unique and possibly conflicting physiological activities (glycolipoids)”. Consequently, there are good omens that unprecedented ‘miracle’ medicines could be developed from sialic acid derivatives. In this review, the first problem, the preparation of sialic acids, is covered, the synthesis of sialic acid derivatives and confirmation of their structures obviously being of critical significance. In addition we needed to confirm their precise stereochemistry and a hydrolysis method has been developed for confirmation of the anomeric position. Several of the compounds have already demonstrated interesting bioactivity
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