Records of Clubiona similis L. Koch, 1867 in the Upper Rhine area in Baden Württemberg/Germany (Araneae: Clubionidae)

Die Sackspinne Clubiona similis L. Koch, 1867 wird in der älteren Literatur aus den verschiedensten Gebieten und Lebensraumtypen Mittel- und Osteuropas erwähnt. Nach HEIMER & NENTWIG (1991) ist sie "in feuchtem Gelände auf niedriger Vegetation" zu finden. Bei HANGGI et al. (1995) werden überwiegend Nachweise aus Küstendünen, daneben einzelne aus Wäldern und extensiv oder ungenutzten Lebensraumtypen des Offenlandes genannt

Spinnen ökologischer Ausgleichsflächen in den Schweizer Kantonen Aargau und Schaffhausen (Arachnida: Araneae) - mit Anmerkungen zu Phrurolithus nigrinus (Corinnidae)

Spiders from ecological compensation areas in the Swiss cantons Aargau and Schaffhausen (Arachnida: Araneae) - with remarks on Phrurolithus nigrinus (Corinnidae). The dpider fauna of open habitats adjacent to arable land was investigated in northern Switzerland. The three habitat types were (1) herbaceous edges of fields (Sa), (2) fallow land sowed with flowers (BB), and (3) grass borders of fields (GS). Four funnel pitfall traps (10 cm diameter) were used to catch spiders in three stripe-types in two geographical regions in two years over 5 weeks in May and June: in total 12 sets of data. Spider species typical for open habitats were dominant, mostly lycosids (6 of 10 most active species). The results were analysed together with environmental factors using a canonical correspondence analysis (CCA) and spiders were compared with carabid beetles (Coeloptera: Carabidae). Geographical region, though not very distant, had the largest influence on both spiders and carabids. The age and type of the habitats had a stronger influence on spiders than on carabids. In spiders a larger part of the total variance was explained by the analysed factors. Finally we discuss briefly a remarkable spider species. A rewiew of all known records of Phrurolithus nigrinus in Switzerland and Germany, together with adjacent regions in France, is given. Its phenology is indicated, its habitat discussed and the overall distribution within Europe is listed

Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity

Dihydropyrimidine dehydrogenase (DPD) is the initial enzyme acting in the catabolism of the widely used antineoplastic agent 5-fluorouracil (5FU). DPD deficiency is known to cause a potentially lethal toxicity following administration of 5FU. Here, we report novel genetic mechanisms underlying DPD deficiency in patients presenting with grade III/IV 5FU-associated toxicity. In one patient a genomic DPYD deletion of exons 21–23 was observed. In five patients a deep intronic mutation c.1129–5923C>G was identified creating a cryptic splice donor site. As a consequence, a 44 bp fragment corresponding to nucleotides c.1129–5967 to c.1129–5924 of intron 10 was inserted in the mature DPD mRNA. The deleterious c.1129–5923C>G mutation proved to be in cis with three intronic polymorphisms (c.483 + 18G>A, c.959–51T>G, c.680 + 139G>A) and the synonymous mutation c.1236G>A of a previously identified haplotype. Retrospective analysis of 203 cancer patients showed that the c.1129–5923C>G mutation was significantly enriched in patients with severe 5FU-associated toxicity (9.1%) compared to patients without toxicity (2.2%). In addition, a high prevalence was observed for the c.1129–5923C>G mutation in the normal Dutch (2.6%) and German (3.3%) population. Our study demonstrates that a genomic deletion affecting DPYD and a deep intronic mutation affecting pre-mRNA splicing can cause severe 5FU-associated toxicity. We conclude that screening for DPD deficiency should include a search for genomic rearrangements and aberrant splicing

Funde der Sackspinne Clubiona similis L. Koch, 1867 am baden-württembergischen Oberrhein/Deutschland (Araneae: Clubionidae)

Records of Clubiona similis L. Koch, 1867 in the Upper Rhine area in Baden-Württemberg/Germany (Araneae: Clubionidae

Funde der Sackspinne Clubiona similis L. Koch, 1867 am baden-w\ufcrttembergischen Oberrhein/Deutschland (Araneae: Clubionidae)

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