Państwo sprawne i życzliwe

rozdział z: Dysfunkcje i patologie w sferze zarządzania zasobami ludzkimi, t. 4, red. Z. JanowskaZgodnie z metodologicznym podejściem Krytycznej Teorii Organizacji autor przeprowadza analizę patologicznej praktyki działania z podstawowymi zasadami ustrojowymi, zawartymi w Konstytucji, a następnie identyfikuje główne przejawy niesprawności w funkcjonowaniu sfery publicznej w latach 1989-2010. Na tej podstawie przedstawia własne propozycje licznych usprawnień w szeroko rozumianej sferze zarządzania publicznego łącznie ze zmianą systemu parlamentarno–gabinetowego na prezydencki i wdrożeniem idei życzliwego państwa.Author, according to the methodology of the Critical Theory of Organization analyses the realization of main rules of Polish Constitution presenting some examples of pathological activity of the public management in the period 1989-2010. He proposes many rational improvements of public management and the change of the political structure of Poland into presidential one, according to American or French style. In the last part of the paper author tries to define some elements of a friendly state

Effective software testing with a string-constraint solver

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2009.Cataloged from PDF version of thesis.Includes bibliographical references (p. 91-100).This dissertation presents techniques and tools for improving software reliability, by using an expressive string-constraint solver to make implementation-based testing more effective and more applicable. Concolic testing is a paradigm of implementation-based systematic software testing that combines dynamic symbolic execution with constraint-based systematic execution-path enumeration. Concolic testing is easy to use and effective in finding real errors. It is, however, limited by the expressiveness of the underlying constraint solver. Therefore, to date, concolic testing has not been successfully applied to programs with highly-structured inputs (e.g., compilers), or to Web applications. This dissertation shows that the effectiveness and applicability of concolic testing can be greatly improved by using an expressive and efficient string-constraint solver, i.e., a solver for constraints on string variables. We present the design, implementation, and experimental evaluation of a novel string-constraint solver. Furthermore, we show novel techniques for two important problems in concolic testing: getting past input validation in programs with highly-structured inputs, and creating inputs that demonstrate security vulnerabilities in Web applications.by Adam Kieżun.Ph.D

Chemerin Effect on the Endometrial Proteome of the Domestic Pig during Implantation Obtained by LC-MS/MS Analysis

Chemerin (CHEM) is a hormone mainly expressed in adipocytes involved in the regulation of energy homeostasis and inflammatory response. CHEM expression has been demonstrated in the structures of the porcine hypothalamic-pituitary-gonadal axis, as well as in the uterus, trophoblasts and conceptuses of pigs. In this study, we performed high-throughput proteomic analyses (liquid chromatography with tandem mass spectrometry, LC-MS/MS) to examine the influence of CHEM (400 ng/mL) on differentially regulated proteins (DRPs) in the porcine endometrial tissue explants during implantation (15 to 16 days of gestation). Among all 352 DRPs, 164 were up-regulated and 188 were down-regulated in CHEM-treated group. DRPs were assigned to 47 gene ontology (GO) terms (p-adjusted < 0.05). Validation of four DRPs (IFIT5, TGFβ1, ACO1 and PGRMC1) by Western blot analysis confirmed the veracity and accuracy of the LC-MS/MS method used in the present study. We suggest that CHEM, by modulating various protein expressions, takes part in the endometrial cell proliferation, migration and invasion at the time of implantation. It also regulates the endometrial immune response, sensitivity to P4 and the formation of new blood vessels. Additionally, CHEM appears to be an important factor involved in endothelial cell dysfunction during the pathogenesis of preeclampsia. The identification of a large number of DRPs under the influence of CHEM provides a valuable resource for understanding the molecular mechanisms of this hormone action during implantation, which is a prerequisite for better control of pig reproduction

Four Riders of the Apocalypse of the Polish Bureaucracy

This article was originally published in Polish as: Witold Kieżun, Czterej jeźdźcy apokalipsy polskiej biurokracji, Kultura, No. 3/630, Paris 2000. The Literary Institute (publisher of the “Kultura” monthly) expressed its interest in and consent to the publication of an English-language version of this article. Professor Witold Kieżun also gave his consent to the translation of his text and its posting in the pages of the journal Foundations of Management. The text was written in 1999 and introduced subsequent to January 1 of that year, regarding the reform of the administrative division of Poland, which involved, among other things, three-stage structure of territorial division and the introduction of counties as administrative units (editorial note)

Four Riders of the Apocalypse of the Polish Bureaucracy

This article was originally published in Polish as: Witold Kieżun, Czterej jeźdźcy apokalipsy polskiej biurokracji, Kultura, No. 3/630, Paris 2000. The Literary Institute (publisher of the “Kultura” monthly) expressed its interest in and consent to the publication of an English-language version of this article. Professor Witold Kieżun also gave his consent to the translation of his text and its posting in the pages of the journal Foundations of Management. The text was written in 1999 and introduced subsequent to January 1 of that year, regarding the reform of the administrative division of Poland, which involved, among other things, three-stage structure of territorial division and the introduction of counties as administrative units (editorial note)

Correction ofvitamin D deficiency/insufficiency and assessment of 24-hour blood pressure parameters in perimenopausal women with arterial hypertension

Both arterial hypertension and vitamin D deficiency are highly prevalent in the general population. Aim of the study was to assess blood pressure and its dynamics in 24-hour ambulatory blood pressure monitoring (ABPM) while correcting the vitamin D deficiency/insufficiency in perimenopausal women, who have grade 2 arterial hypertension. Material and methods: The study group consisted of 50 premenopausal women [48 (45–50) years] and 52 women in early (up to 5 years) postmenopausal period [52 (50–54) years]. Total 25-(OH)D blood plasma levels were assessed by immunoenzyme assay using DRG kit (Marburg, Germany). The total 25-(OH)D blood plasma levels below 20 ng/ml were considered as vitamin D insufficiency, the concentration of 20–30 ng/ml – as deficiency, and the levels 30–60 ng/ml were considered normal. In the group of women with 25-(OH)D deficiency/insufficiency two subgroups were isolated: IB subgroup (n = 25) and IIB (n = 21), which were introduced with treatment algorithm, including cholecalciferol administration at a daily dose of 2000 IU for 3 months. Results: Cholecalciferol therapy at a dose of 2000 IU per day for a period of 3 months has allowed reaching the optimum concentration of vitamin D in 80% of premenopausal hypertensive women, and in 76.2% of women in the early postmenopausal period. Correction of plasma vitamin D deficiency achieved by taking cholecalciferol, while using combined antihypertensive therapy (ramipril + indapamide) allows to improve the following parameters assessed in ambulatory blood pressure monitoring in premenopausal women: the mean daytime and nighttime systolic blood pressure, time index of 24-hour and daytime systolic blood pressure, nighttime blood pressure variability, systolic and diastolic blood pressure morning surge, and normalization of nighttime:daytime blood pressure ratio; in postmenopausal women the treatment allowed: the reduction of morning surge of diastolic blood pressure, normalization of daytime systolic blood pressure variability, and nighttime diastolic blood pressure time index

High-Dose Fenofibrate Stimulates Multiple Cellular Stress Pathways in the Kidney of Old Rats

We investigated the age-related effects of the lipid-lowering drug fenofibrate on renal stress-associated effectors. Young and old rats were fed standard chow with 0.1% or 0.5% fenofibrate. The kidney cortex tissue structure showed typical aging-related changes. In old rats, 0.1% fenofibrate reduced the thickening of basement membranes, but 0.5% fenofibrate exacerbated interstitial fibrosis. The PCR array for stress and toxicity-related targets showed that 0.1% fenofibrate mildly downregulated, whereas 0.5% upregulated multiple genes. In young rats, 0.1% fenofibrate increased some antioxidant genes’ expression and decreased the immunoreactivity of oxidative stress marker 4-HNE. However, the activation of cellular antioxidant defenses was impaired in old rats. Fenofibrate modulated the expression of factors involved in hypoxia and osmotic stress signaling similarly in both age groups. Inflammatory response genes were variably modulated in the young rats, whereas old animals presented elevated expression of proinflammatory genes and TNFα immunoreactivity after 0.5% fenofibrate. In old rats, 0.1% fenofibrate more prominently than in young animals induced phospho-AMPK and PGC1α levels, and upregulated fatty acid oxidation genes. Our results show divergent effects of fenofibrate in young and old rat kidneys. The activation of multiple stress-associated effectors by high-dose fenofibrate in the aged kidney warrants caution when applying fenofibrate therapy to the elderly