5,903 research outputs found
Programmable biomaterials for dynamic and responsive drug delivery
Biomaterials are continually being designed that enable new methods for interacting dynamically with cell and tissues, in turn unlocking new capabilities in areas ranging from drug delivery to regenerative medicine. In this review, we explore some of the recent advances being made in regards to programming biomaterials for improved drug delivery, with a focus on cancer and infection. We begin by explaining several of the underlying concepts that are being used to design this new wave of drug delivery vehicles, followed by examining recent materials systems that are able to coordinate the temporal delivery of multiple therapeutics, dynamically respond to changing tissue environments, and reprogram their bioactivity over time
The Thermodynamics of Network Coding, and an Algorithmic Refinement of the Principle of Maximum Entropy
The principle of maximum entropy (Maxent) is often used to obtain prior
probability distributions as a method to obtain a Gibbs measure under some
restriction giving the probability that a system will be in a certain state
compared to the rest of the elements in the distribution. Because classical
entropy-based Maxent collapses cases confounding all distinct degrees of
randomness and pseudo-randomness, here we take into consideration the
generative mechanism of the systems considered in the ensemble to separate
objects that may comply with the principle under some restriction and whose
entropy is maximal but may be generated recursively from those that are
actually algorithmically random offering a refinement to classical Maxent. We
take advantage of a causal algorithmic calculus to derive a thermodynamic-like
result based on how difficult it is to reprogram a computer code. Using the
distinction between computable and algorithmic randomness we quantify the cost
in information loss associated with reprogramming. To illustrate this we apply
the algorithmic refinement to Maxent on graphs and introduce a Maximal
Algorithmic Randomness Preferential Attachment (MARPA) Algorithm, a
generalisation over previous approaches. We discuss practical implications of
evaluation of network randomness. Our analysis provides insight in that the
reprogrammability asymmetry appears to originate from a non-monotonic
relationship to algorithmic probability. Our analysis motivates further
analysis of the origin and consequences of the aforementioned asymmetries,
reprogrammability, and computation.Comment: 30 page
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