Covid-19 And Jaundice In Infants

In Tbilisi State Medical University First University Clinic Department of Perinatology, within a framework of retrospective study, the medical histories of 23 pregnant women in 2022 (infected with Sars-CoV-2 at different stages of pregnancy and childbirth) and their newborns were studied   which are  transferred in the Neonatal Intensive Care Unit (NICU), due to jaundice, for the  phototherapy  and further monitoring of bilirubin level. As it was determined by data analysis, in 17 out of 23 cases, SARS-CoV-2 infection during pregnancy and childbirth were characterized by a moderate or severe duration of infection, and their newborns were diagnosed with jaundice with an unspecified cause.Based on our study, it can be assumed that   jaundice   in newborns, which appeared due to  hyperbilirubinemia  is a neonatal consequence of SARS-CoV-2 ,which  probably cause placental vascular malperfusion and polycythemia in fetuses, which may be a compensatory response to this infection

Induction Of Labour By Combined Methods Of Induction-Case Report

The timely onset of labor is an important determinant of perinatal outcome. Induction of labour  or   the artificial initiation of  labour   ,  is   a   common intervention in modern obstetrics.   One of the most common reasons for labor induction   is postterm   pregnancy (i.e.  > 41 weeks of gestation). Pregnant woman G3P2 applied to   the   TSMU   The   First University Clinic at 41 weeks, induction of   labor   was    offered   to    her , by mechanical    method – Foleys  catheter  after written consent. Before and after  induction  of labour by mechanical method, we evaluated    uterine cervix   by  the same  3 points according to Bishop's scoring system. Since the pregnant woman did not have a   regular    uterine    contractions,  after  this mechanical method, a medical method of labor induction was offered to her, with the drug Cytotec (misoprostol), to which the pregnant woman again gave her written consent. The specified dose was given 1 time, after which a regular labor was established every 10 minutes 3 times with a duration of 35-40 seconds. The cervix was evaluated according to Bishop's  scoring   system with  8 points, an amniotomy was performed and the woman gave birth in 5 hours, without complications, the newborn was evaluated with 7/8 points according to the Apgar scoring system. We  suggest   that   Foley catheter in combination   with  oral misoprostol is  an alternative   way  for induction of labor.  The  combination   of   this   different methods of induction  reduces labor duration, which provide good outcome

SARS-Cov-2 Spike Protein Antibody Titers In Cord Blood After Vaccination Against Covid-19 During Pregnancy

In the early months of the COVID-19 pandemic, pregnant patients faced uncertain risks associated with severe acute respiratory syndrome SARS-CoV-2 viral infection. Aim of the study was to determine the titer of specific maternal and umbilical cord antibodies against SARS-CoV-2 viral protein S receptor domain after maternal antenatal vaccination. The paper presents preliminary results of the study proceeded in the department. 13 patients vaccinated during different gestational age have been included in the study. All patients participating in this study were vaccinated with two doses of BNT162b2 mRNA COVID-19 vaccine between the 4 to 31 week of gestation. The in vitro qualitative and quantitative determination of antibodies against SARS-CoV-2 viral protein S receptor domain in serum samples was performed by using an electrochemiluminescence immunoassay.  Study results demonstrated that, vaccination against SARS-Cov-2 viral infection during pregnancy is accompanied with adequate production of antibodies that probably may defense neonates from severe infection at least within 6 month of life. Study has revealed positive correlation between time interval of vaccination and delivery for the presence of high titers of SARS-Cov-2 viral protein S receptor domain antibodies in neonatal cord blood, which may allow future determination of the optimal timing of COVID-19 vaccination in pregnant women although this problem need more future studies

COVID-19 Pregnancy and Psycho-neurological Disturbance: Single Hospital Case Report

31 years old pregnant woman at 38 1/7 week of gestation with fever has been admitted to the TSMU   First University Clinic Emergency, with positive COVID-19 PCR test. With characteristic complains of COVID-19 infection.  Family history not significant. Personal history reveals childhood seizure as a result of fever. Vital signs at the admission within normal ranges. All protocol based laboratory tests has been done and protocol based treatment initiated. On the seventh day of Covid-19 infection because of episodes of desaturation and termed gestation, pregnancy termination by induction has been done successfully. At the end of early puerperal period because of hypoxemia resistant to oxygen therapy and CT scan diagnosed severe viral induced pneumonia, with symptoms of encephalopathy has been documented.  Later patient transferred to the mechanical ventilation, protocol based lab tests, diagnostic procedures and treatment initiated. After 1 month with improved condition patient has been transferred to the ob/gyn department for ongoing treatment and rehabilitation at this time severely expressed symptoms of encephalopathy were documented.The underlying mechanisms of neurologic complications in patients with COVID-19 are diverse and, in some cases, multifactorial. Neurologic complications may arise from direct effects of the virus as well as systemic response to the infection or as a result of long lasting inadequate oxygenation of all tissues. Although mechanical ventilation is highly complicated by brain damage, covid-19 induced encephalopathies are as well documented and need more scientifically proved facts of the viral role in this complication