A spectacularity concept in modern philosophy

The paper focuses on the interpretation problem of the concept of spectacularity in modern philosophy. The particularities of different conceptions of spectacularity are analyzed and the special attention is paid to its role in the development of the modern society. The main objective of the article is the critical analysis of different theories of philosophers and cultural experts in the context of the spectacularity phenomenon. The research applies the methods of the systematic approach and contextual analysis. The novelty of the paper lies in the formation of the strengths and weaknesses of the spectacularity concepts and in the development of certain principles of the interdisciplinary study of the phenomenon. This research could be of interest for professionals working in the field of sociology of culture and philosophy of culture

Methylation of the BIN1 gene promoter CpG island associated with breast and prostate cancer

<p>Abstract</p> <p>Background</p> <p>Loss of BIN1 tumor suppressor expression is abundant in human cancer and its frequency exceeds that of genetic alterations, suggesting the role of epigenetic regulators (DNA methylation). <it>BIN1 </it>re-expression in the DU145 prostate cancer cell line after 5-aza-2'-deoxycytidine treatment was recently reported but no methylation of the <it>BIN1 </it>promoter CpG island was found in DU145.</p> <p>Methods</p> <p>Methylation-sensitive arbitrarily-primed PCR was used to detect genomic loci abnormally methylated in breast cancer. <it>BIN1 </it>CpG island fragment was identified among the differentially methylated loci as a result of direct sequencing of the methylation-sensitive arbitrarily-primed PCR product and subsequent BLAST alliance. <it>BIN1 </it>CpG island cancer related methylation in breast and prostate cancers was confirmed by bisulphite sequencing and its methylation frequency was evaluated by methylation sensitive PCR. Loss of heterozygosity analysis of the BIN1 region was performed with two introgenic and one closely adjacent extragenic microsatellite markers.<it>BIN1 </it>expression was evaluated by real-time RT-PCR.</p> <p>Results</p> <p>We have identified a 3'-part of <it>BIN1 </it>promoter CpG island among the genomic loci abnormally methylated in breast cancer. The fragment proved to be methylated in 18/99 (18%) and 4/46 (9%) breast and prostate tumors, correspondingly, as well as in MCF7 and T47D breast cancer cell lines, but was never methylated in normal tissues and lymphocytes as well as in DU145 and LNCaP prostate cancer cell lines. The 5'-part of the CpG island revealed no methylation in all samples tested. <it>BIN1 </it>expression losses were detected in MCF7 and T47D cells and were characteristic of primary breast tumors (10/13; 77%), while loss of heterozygosity was a rare event in tissue samples (2/22 informative cases; 9%) and was ruled out for MCF7.</p> <p>Conclusion</p> <p><it>BIN1 </it>promoter CpG island is composed of two parts differing drastically in the methylation patterns in cancer. This appears to be a common feature of cancer related genes and demands further functional significance exploration. Although we have found no evidence of the functional role of such a non-core methylation in <it>BIN1 </it>expression regulation, our data do not altogether rule this possibility out.</p

A spectacularity concept in modern philosophy

The paper focuses on the interpretation problem of the concept of spectacularity in modern philosophy. The particularities of different conceptions of spectacularity are analyzed and the special attention is paid to its role in the development of the modern society. The main objective of the article is the critical analysis of different theories of philosophers and cultural experts in the context of the spectacularity phenomenon. The research applies the methods of the systematic approach and contextual analysis. The novelty of the paper lies in the formation of the strengths and weaknesses of the spectacularity concepts and in the development of certain principles of the interdisciplinary study of the phenomenon. This research could be of interest for professionals working in the field of sociology of culture and philosophy of culture

Investigation of the effect of additives on the basis of pickling solutions containing iron salts on the structure and strength of fine concrete

The modern tendencies of construction industry development are connected with the use of new high-efficient materials with the application of resource- and energy-saving technologies of their generation. The use of industrial man-made products as the components improving the characteristics of construction products is now a promising field of research. The article presents the results of the use of waste pickling solutions of steel rolling factories, containing salts of iron as nanomodified additives for the products based on cement binder. The effectiveness of the influence of the considered additives on the structure and strength of fine-grained concrete is shown. If using this additive in the amount of 0.32 % from the mass of cement for 28 days of natural hardening, the fine concrete strength is growing by 1.8 times due to additional formation of hydrosilicates, densification of structure and reduction of the total porosity of the cement system by 2 times