Spatial asymmetry of optically excited spin waves in anisotropic ferromagnetic film

We analytically discuss and micromagnetically prove the ways to tune the spatial asymmetry of the initial phase, amplitude, and wavevectors of magnetostatic waves driven by ultrafast laser excitation. We consider that the optical pulse heats a thin ferromagnetic metallic film and abruptly decreases the saturation magnetization and the parameter of uniaxial anisotropy. The two corresponding terms of laser-induced torque have different azimuthal symmetries, with the 4-fold symmetry of the demagnetization-related term, and the isotropic distribution of the anisotropy-related term. As a result, the initial phase and amplitude of excited magnetostatic waves have a non-trivial azimuthal distribution tunable with the angle between the external magnetic field and anisotropy axis, and the laser spot diameter. Moreover, the variation of these parameters tunes the distribution of wavevectors, resulting in additional asymmetry between the spectral components of the waves propagating in different directions.Comment: 8 pages, 5 figure

A Physical Model for SN 2001ay, a normal, bright, extremely slowly declining Type Ia supernova

We present a study of the peculiar Type Ia supernova 2001ay (SN 2001ay). The defining features of its peculiarity are: high velocity, broad lines, and a fast rising light curve, combined with the slowest known rate of decline. It is one magnitude dimmer than would be predicted from its observed value of Delta-m15, and shows broad spectral features. We base our analysis on detailed calculations for the explosion, light curves, and spectra. We demonstrate that consistency is key for both validating the models and probing the underlying physics. We show that this SN can be understood within the physics underlying the Delta-m15 relation, and in the framework of pulsating delayed detonation models originating from a Chandrasekhar mass, white dwarf, but with a progenitor core composed of 80% carbon. We suggest a possible scenario for stellar evolution which leads to such a progenitor. We show that the unusual light curve decline can be understood with the same physics as has been used to understand the Delta-m15 relation for normal SNe Ia. The decline relation can be explained by a combination of the temperature dependence of the opacity and excess or deficit of the peak luminosity, alpha, measured relative to the instantaneous rate of radiative decay energy generation. What differentiates SN 2001ay from normal SNe Ia is a higher explosion energy which leads to a shift of the Ni56 distribution towards higher velocity and alpha < 1. This result is responsible for the fast rise and slow decline. We define a class of SN 2001ay-like SNe Ia, which will show an anti-Phillips relation.Comment: 35 pages, 14 figures, ApJ, in pres

SN 2003du: Signatures of the Circumstellar Environment in a Normal Type Ia Supernova?

We present observations of the Type Ia supernova 2003du and report the detectionof an unusual, high-velocity component in the Ca II infrared triplet, similar tofeatures previously observed in SN 2000cx and SN 2001el. This feature exhibits a large expansion velocity (~18,000 km/s) which is nearly constant between -7 and +2 days relative to maximum light, and disappears shortly thereafter. Otherthan this feature, the spectral evolution and light curve resemble those of a normal SN Ia. We find that the Ca II feature can plausibly be caused by a dense shell formed when circumstellar material of solar abundance is overrun by the rapidly expanding outermost layers of the SN ejecta. Model calculations show that the optical and infrared spectra are remarkably unaffected by the circumstellar interaction. In particular, no hydrogen lines are detectable in either absorption or emission. The only qualitatively different features are the strong, high-velocity feature in the Ca II IR-triplet, and a somewhat weaker O I feature near 7,300 AA. The morphology and time evolution of these features provide an estimate for the amount of accumulated matter and an indication of the mixing in the dense shell. We apply these diagnostic tools to SN 2003du and infer that about 2 x 10^{-2} M_sun of solar abundance material may have accumulated in a circumstellar shell prior to the observations. Furthermore, the early light curve data imply that the circumstellar material was originally very close to the progenitor system, perhaps from an accretion disk, Roche lobe or common envelope.Comment: 35 Pages, 11 Figures, to appear in ApJ. Resubmission includes expanded discussion & new figures to match with accepted journal versio

Pharmacogenetics of Antidepressants: from Genetic Findings to Predictive Strategies

The constantly growing contribution of depressive disorders to the global disease statistics calls for a growth of treatment effectiveness and optimization. Antidepressants are the most frequently prescribed medicines for depressive disorders. However, development of a standardized pharmacotherapeutic approach is burdened by the genomic heterogeneity, lack of reliable predictive biomarkers and variability of the medicines metabolism aggravated by multiple side effects of antidepressants. According to modern assessments up to 20 % of the genes expressed in our brain are involved in the pathogenesis of depression. Large-scale genetic and genomic research has found a number of potentially prognostic genes. It has also been proven that the effectiveness and tolerability of antidepressants directly depend on the variable activity of the enzymes that metabolize medicines. Almost all modern antidepressants are metabolized by the cytochrome P450 family enzymes. The most promising direction of research today is the GWAS (Genome-Wide Association Study) method that is aimed to link genomic variations with phenotypical manifestations. In this type of research genomes of depressive patients with different phenotypes are compared to the genomes of the control group containing same age, sex and other parameters healthy people. Notably, regardless of the large cohorts of patients analyzed, none of the GWA studies conducted so far can reliably reproduce the results of other analogous studies. The explicit heterogeneity of the genes associated with the depression pathogenesis and their pleiotropic effects are strongly influenced by environmental factors. This may explain the difficulty of obtaining clear and reproducible results. However, despite any negative circumstances, the active multidirectional research conducted today, raises the hope of clinicians and their patients to get a whole number of schedules how to achieve remission faster and with guaranteed result

Analysis of the Flux and Polarization Spectra of the Type Ia Supernova SN 2001el: Exploring the Geometry of the High-velocity Ejecta

SN 2001el is the first normal Type Ia supernova to show a strong, intrinsic polarization signal. In addition, during the epochs prior to maximum light, the CaII IR triplet absorption is seen distinctly and separately at both normal photospheric velocities and at very high velocities. The high-velocity triplet absorption is highly polarized, with a different polarization angle than the rest of the spectrum. The unique observation allows us to construct a relatively detailed picture of the layered geometrical structure of the supernova ejecta: in our interpretation, the ejecta layers near the photosphere (v \approx 10,000 km/s) obey a near axial symmetry, while a detached, high-velocity structure (v \approx 18,000-25,000 km/s) with high CaII line opacity deviates from the photospheric axisymmetry. By partially obscuring the underlying photosphere, the high-velocity structure causes a more incomplete cancellation of the polarization of the photospheric light, and so gives rise to the polarization peak and rotated polarization angle of the high-velocity IR triplet feature. In an effort to constrain the ejecta geometry, we develop a technique for calculating 3-D synthetic polarization spectra and use it to generate polarization profiles for several parameterized configurations. In particular, we examine the case where the inner ejecta layers are ellipsoidal and the outer, high-velocity structure is one of four possibilities: a spherical shell, an ellipsoidal shell, a clumped shell, or a toroid. The synthetic spectra rule out the spherical shell model, disfavor a toroid, and find a best fit with the clumped shell. We show further that different geometries can be more clearly discriminated if observations are obtained from several different lines of sight.Comment: 14 pages (emulateapj5) plus 18 figures, accepted by The Astrophysical Journa

Thermonuclear Supernovae: Simulations of the Deflagration Stage and Their Implications

Large-scale three-dimensional numerical simulations of the deflagration stage of a thermonuclear supernova explosion show the formation and evolution of a highly convoluted turbulent flame in a gravitational field of an expanding carbon-oxygen white dwarf. The flame dynamics is dominated by the gravity-induced Rayleigh-Taylor instability that controls the burning rate. The thermonuclear deflagration releases enough energy to produce a healthy explosion. The turbulent flame, however, leaves large amounts of unburnt and partially burnt material near the star center, whereas observations imply these materials only in outer layers. This disagreement could be resolved if the deflagration triggers a detonation.Comment: 17 pages, 5 figures. To appear in Science, January 200

Direct Numerical Simulations of Type Ia Supernovae Flames II: The Rayleigh-Taylor Instability

A Type Ia supernova explosion likely begins as a nuclear runaway near the center of a carbon-oxygen white dwarf. The outward propagating flame is unstable to the Landau-Darrieus, Rayleigh-Taylor, and Kelvin-Helmholtz instabilities, which serve to accelerate it to a large fraction of the speed of sound. We investigate the Rayleigh-Taylor unstable flame at the transition from the flamelet regime to the distributed-burning regime, around densities of $10^7$ g/cc, through detailed, fully resolved simulations. A low Mach number, adaptive mesh hydrodynamics code is used to achieve the necessary resolution and long time scales. As the density is varied, we see a fundamental change in the character of the burning--at the low end of the density range the Rayleigh-Taylor instability dominates the burning, whereas at the high end the burning suppresses the instability. In all cases, significant acceleration of the flame is observed, limited only by the size of the domain we are able to study. We discuss the implications of these results on the potential for a deflagration to detonation transition.Comment: submitted to ApJ, some figures degraded due to size constraint

Model Flames in the Boussinesq Limit: The Effects of Feedback

We have studied the fully nonlinear behavior of pre-mixed flames in a gravitationally stratified medium, subject to the Boussinesq approximation. Key results include the establishment of criterion for when such flames propagate as simple planar flames; elucidation of scaling laws for the effective flame speed; and a study of the stability properties of these flames. The simplicity of some of our scalings results suggests that analytical work may further advance our understandings of buoyant flames.Comment: 11 pages, 14 figures, RevTex, gzipped tar fil