7 research outputs found
A European research agenda for somatic symptom disorders, bodily distress disorders, and functional disorders: Results of an estimate-talk-estimate delphi expert study
Background: Somatic Symptom Disorders (SSD), Bodily Distress Disorders (BDD) and functional disorders (FD) are associated with high medical and societal costs and pose a substantial challenge to the population and health policy of Europe. To meet this challenge, a specific research agenda is needed as one of the cornerstones of sustainable mental health research and health policy for SSD, BDD, and FD in Europe.
Aim: To identify the main challenges and research priorities concerning SSD, BDD, and FD from a European perspective.
Methods: Delphi study conducted from July 2016 until October 2017 in 3 rounds with 3 workshop meetings and 3 online surveys, involving 75 experts and 21 European countries. EURONET-SOMA and the European Association of Psychosomatic Medicine (EAPM) hosted the meetings.
Results: Eight research priorities were identified: (1) Assessment of diagnostic profiles relevant to course and treatment outcome. (2) Development and evaluation of new, effective interventions. (3) Validation studies on questionnaires or semi-structured interviews that assess chronic medical conditions in this context. (4) Research into patients preferences for diagnosis and treatment. (5) Development of new methodologic designs to identify and explore mediators and moderators of clinical course and treatment outcomes (6). Translational research exploring how psychological and somatic symptoms develop from somatic conditions and biological and behavioral pathogenic factors. (7) Development of new, effective interventions to personalize treatment. (8) Implementation studies of treatment interventions in different settings, such as primary care, occupational care, general hospital and specialty mental health settings. The general public and policymakers will benefit from the development of new, effective, personalized interventions for SSD, BDD, and FD, that will be enhanced by translational research, as well as from the outcomes of research into patient involvement, GP-patient communication, consultation-liaison models and implementation.
Conclusion: Funding for this research agenda, targeting these challenges in coordinated research networks such as EURONET-SOMA and EAPM, and systematically allocating resources by policymakers to this critical area in mental and physical well-being is urgently needed to improve efficacy and impact for diagnosis and treatment of SSD, BDD, and FD across Europe
ΠΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΡΠΉ ΠΈΠ½ΡΠ΅Π»Π»Π΅ΠΊΡ Π² ΠΎΡΡΠ°Π»ΡΠΌΠΎΠ»ΠΎΠ³ΠΈΠΈ. ΠΡΠΆΠ½Ρ Π»ΠΈ Π½Π°ΠΌ ΠΊΠ°Π»ΡΠΊΡΠ»ΡΡΠΎΡΡ ΡΠΈΡΠΊΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π³Π»Π°ΡΠΊΠΎΠΌΡ?
Artificial intelligence (AI) is rapidly entering modern medical practice. Many routine clinical tasks, from imaging and automated diagnostics to robotic surgery, cannot be imagined without the use of AI. Neural networks show impressive results when analyzing a large amount of data obtained from standard automated perimetry, optical coherence tomography (OCT) and fundus photography. Currently, both in Russia and abroad mathematical algorithms are being developed that allow detection of glaucoma based on certain signs. This article analyzes the advantages and disadvantages of employing artificial intelligence in ophthalmological practice, discusses the need for careful selection of the criteria and their influence on the accuracy of calculators, considers the specifics of using mathematical analysis in suspected glaucoma, as well as in an already established diagnosis. The article also provides clinical examples of the use of glaucoma risk calculator in the routine practice of an ophthalmologist.ΠΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΡΠΉ ΠΈΠ½ΡΠ΅Π»Π»Π΅ΠΊΡ (ΠΠ) ΡΡΡΠ΅ΠΌΠΈΡΠ΅Π»ΡΠ½ΠΎ Π²Ρ
ΠΎΠ΄ΠΈΡ Π² ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΡΡ ΠΏΡΠ°ΠΊΡΠΈΠΊΡ. ΠΠ½ΠΎΠ³ΠΈΠ΅ ΠΏΠΎΠ²ΡΠ΅Π΄Π½Π΅Π²Π½ΡΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π·Π°Π΄Π°ΡΠΈ, ΠΎΡ Π²ΠΈΠ·ΡΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΈ Π°Π²ΡΠΎΠΌΠ°ΡΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ Π΄ΠΎ ΡΠΎΠ±ΠΎΡΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Ρ
ΠΈΡΡΡΠ³ΠΈΠΈ Π½Π΅Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ ΡΠ΅Π³ΠΎΠ΄Π½Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²ΠΈΡΡ Π±Π΅Π· ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΠ. ΠΠ΅ΠΉΡΠΎΠ½Π½ΡΠ΅ ΡΠ΅ΡΠΈ ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ Π²ΠΏΠ΅ΡΠ°ΡΠ»ΡΡΡΠΈΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΡΠΈ Π°Π½Π°Π»ΠΈΠ·Π΅ Π±ΠΎΠ»ΡΡΠΎΠ³ΠΎ ΠΌΠ°ΡΡΠΈΠ²Π° Π΄Π°Π½Π½ΡΡ
, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΏΡΠΈ ΠΊΠΎΠΌΠΏΡΡΡΠ΅ΡΠ½ΠΎΠΉ ΠΏΠ΅ΡΠΈΠΌΠ΅ΡΡΠΈΠΈ, ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠΎΠ³Π΅ΡΠ΅Π½ΡΠ½ΠΎΠΉ ΡΠΎΠΌΠΎΠ³ΡΠ°ΡΠΈΠΈ, ΡΠΎΡΠΎΠ³ΡΠ°ΡΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Π³Π»Π°Π·Π½ΠΎΠ³ΠΎ Π΄Π½Π° ΠΈ Π΄Ρ. Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Π² Π ΠΎΡΡΠΈΠΈ ΠΈ Π·Π° ΡΡΠ±Π΅ΠΆΠΎΠΌ ΡΠ°Π·ΡΠ°Π±Π°ΡΡΠ²Π°ΡΡΡΡ ΠΌΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ Π°Π»Π³ΠΎΡΠΈΡΠΌΡ, ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡΠΈΠ΅ ΠΏΠΎ ΡΠ΅ΠΌ ΠΈΠ»ΠΈ ΠΈΠ½ΡΠΌ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΡΡ Π½Π°Π»ΠΈΡΠΈΠ΅ Π³Π»Π°ΡΠΊΠΎΠΌΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°. Π ΡΡΠ°ΡΡΠ΅ Π°Π½Π°Π»ΠΈΠ·ΠΈΡΡΡΡΡΡ ΠΏΠ»ΡΡΡ ΠΈ ΠΌΠΈΠ½ΡΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΠ Π² ΠΎΡΡΠ°Π»ΡΠΌΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅. ΠΠ±ΡΡΠΆΠ΄Π°Π΅ΡΡΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Π±ΠΎΡΠ° ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅Π² ΠΈ ΠΈΡ
Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΡΠΎΡΠ½ΠΎΡΡΡ ΡΠ°Π±ΠΎΡΡ ΠΊΠ°Π»ΡΠΊΡΠ»ΡΡΠΎΡΠΎΠ². ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠ°ΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° ΠΏΡΠΈ ΠΏΠΎΠ΄ΠΎΠ·ΡΠ΅Π½ΠΈΠΈ Π½Π° Π³Π»Π°ΡΠΊΠΎΠΌΡ ΠΈ ΠΏΡΠΈ ΡΠΆΠ΅ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΠ·Π΅. ΠΡΠΈΠ²ΠΎΠ΄ΡΡΡΡ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠΈΠΌΠ΅ΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ°Π»ΡΠΊΡΠ»ΡΡΠΎΡΠ° ΡΠΈΡΠΊΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ Π³Π»Π°ΡΠΊΠΎΠΌΡ Π² ΡΡΡΠΈΠ½Π½ΠΎΠΉ ΠΏΡΠ°ΠΊΡΠΈΠΊΠ΅ ΠΎΡΡΠ°Π»ΡΠΌΠΎΠ»ΠΎΠ³Π°.
Bio-hybridization of nanobactericides with cellulose films for effective treatment against members of ESKAPE drug resistant pathogens
The rapid expansion of drug-resistant pathogens has created huge global impact and development of novel antimicrobial
leads is one of the top priority studies in the current scenario. The present study aims to develop bio-hybridized nanocellulose
films which comprise of phytogenic silver nanobactericides. The nanobactericides were synthesized by treating 1 mM
silver nitrate with aqueous extract of Chamerion angustifolium which reduced the metal salt to produce polydispersed
nanobactericides which were tested against the members of ESKAPE drug-resistant communities. The synthesized silver
nanobactericides were subjected to characterization with UVβvisible spectra which displayed maximum absorbance at
408 nm. The bio-molecular interaction of phyto-constituents to mediate synthesis and stabilization of nanobactericides was
studied with Fourier-transform infrared spectroscopy (FTIR) which depicted functional groups associated with nanobactericides.
The crystalline nature was studied with X-ray diffraction (XRD) which showed Braggβs intensities at 2ΞΈ angle which
denoted (111), (200), (220), and (311) planes. The morphological characteristics of silver nanobactericides were defined
with transmission electron Microscopy (TEM) image which displayed polydispersity of silver nanobactericides with size
ranging from 2 to 40 nm. The synthesized nanobactericides showed a significant activity against MRSA strain with 21 mm
zone of inhibition. The minimal inhibitory concentration of silver nanobactericides to inhibit the growth of test pathogens
was also determined which ranged between 0.625 and 1.25 ΞΌg/ml. The silver nanobactericides were bio-hybridized onto
nanocellulose films produced by Komagataeibacter xylinus B-12068 culture strain. The films were dried to determine the
mechanical properties which showed increased in Youngβs modulus and tensile strength in comparison with control bacterial
cellulose films. Overall, the results obtained in the present investigation are promising enough to report bactericidal activity
of bio-hybridized nanobactericidal films against ESKAPE. These communities are reported to cause severe threats to all
forms of lives irrespective to their habitats which can lead to huge economical crisis