Eccrine poromatosis following chemotherapy and radiation therapy

Eccrine poroma presents as a single, symptomless erythematous papule in areas with a high density of eccrine sweat glands. Although rare, eccrine poromas can present as multiple lesions, otherwise known as eccrine poromatosis. The etiology of eccrine poromatosis is unclear. We present two cases of eccrine poromatosis in patients who had undergone chemotherapy, radiation therapy, and stem cell transplant. This case report serves to raise awareness of this condition and highlight its association with malignancies and their treatment

Warehouse Management Application for Android

This Bachelor’s Thesis was about the process of fully developing a native application that runs on the Android platform. The objective of this Thesis was to demonstrate the steps, tools, and Android fundamentals that are needed to make an idea of an Android application become reality. After the theory about the Android development was covered, it was put into practice by implementing a fully functional application. This was a warehouse management system (WMS) which runs on the Android platform. The aim of this application was not only to speed up the work of a warehouse manager, but also to minimize their mistakes by replacing pen and paper with an application that runs on a handheld device such as a tablet. This application was built by the author and one of his friends when they worked for a company for their training project. This app was built using the knowledge the author acquired from his degree together with his own research about the Android development. The task is to build the front-end of the application as well as the logic behind it. The server side part of this application was made by the author's friend. Therefore, only the developing process of front-end functions of the application is described in this Thesis. This application was built using Android Studio. As a result, this application works very well and fulfills every requirement. It still has many potential functions that could be implemented to be more effective and up to date, such as the UI customization and performance optimization

An Investigation of the DNA Interactions of Polyamine Anthracene Conjugates under High Ionic Conditions

Six polyamine anthracene conjugates (Ants) were studied that take advantage of the polyamine transporter system (PTS) to target specific cancer. The structural features of the Ants involve planar aromatic anthracene that has highly cytotoxicity properties and a polyamine chain similar to natural polyamine, which is taken up by eukaryote cells expressing the PTS actively. Experimental data show that Ants with di-substituted polyamine chains have significantly higher DNA binding affinities than the mono-substituted anthracene conjugates. The high ionic conditions (~150 mM NaCl and 260 mM KCl) in the eukaryote cell nucleus extensively impair the apparent DNA binding of the Ants, but may further reinforce DNA structural stability. Combining the published cytotoxicity of the PTS data with the DNA interaction data reported here, the di-substituted polyamine anthracene conjugates have the highest potential to, after cellular uptake via PTS, bind to DNA