Blockchain-based Healthcare Portal – A Bibliometric Analysis

User privacy has been a topmost priority and one such domain where this is neglected is the area of healthcare. Our solution focuses on the idea of using blockchain to provide a platform for healthcare experts and patients, giving patients full control over the data that will be shared. This paper focuses on identifying current research that has been conducted in this area in the form of a bibliometric analysis. A bibliometric study on a research area involves a detailed analysis of citations and papers across a domain of study. The purpose of this study is a statistical analysis of publications which is so complex that it is close to impossible to understand trends merely based on knowledge and experience. There are specific tools required to recognize these trends based on the bibliometric data. This paper will give an outlook on the areas of blockchain that were explored by various papers, the criteria and pattern followed by the combination of papers, and a cumulative statistical analysis of the papers that were fetched for the purpose of our study from the Scopus database. The most popular visualization software tool VOSviewer was taken into use

miR-184 Regulates Pancreatic β-Cell Function According to Glucose Metabolism

In response to fasting or hyperglycemia, the pancreatic β-cell alters its output of secreted insulin; however, the pathways governing this adaptive response are not entirely established. Although the precise role of microRNAs (miRNAs) is also unclear, a recurring theme emphasizes their function in cellular stress responses. We recently showed that miR-184, an abundant miRNA in the β-cell, regulates compensatory proliferation and secretion during insulin resistance. Consistent with previous studies showing miR-184 suppresses insulin release, expression of this miRNA was increased in islets after fasting, demonstrating an active role in the β-cell as glucose levels lower and the insulin demand ceases. Additionally, miR-184 was negatively regulated upon the administration of a sucrose-rich diet in Drosophila, demonstrating strong conservation of this pathway through evolution. Furthermore, miR-184 and its target Argonaute2 remained inversely correlated as concentrations of extracellular glucose increased, underlining a functional relationship between this miRNA and its targets. Lastly, restoration of Argonaute2 in the presence of miR-184 rescued suppression of miR-375-targeted genes, suggesting these genes act in a coordinated manner during changes in the metabolic context. Together, these results highlight the adaptive role of miR-184 according to glucose metabolism and suggest the regulatory role of this miRNA in energy homeostasis is highly conserved