Contribution à l'étude fonctionnelle des industries lithiques sauveterriennes (comparaison de deux sites du Sud-Est de la France (Le Sansonnet et le Pey de Durance) et de la Suisse occidentale (La Baume d'Ogens et Le Château-d'Oex)

AIX-MARSEILLE1-BU Lettres (130012101) / SudocSudocFranceF

Implication of Xenobiotic Metabolizing Enzyme gene (CYP2E1, CYP2C19, CYP2D6, mEH and NAT2) Polymorphisms in Breast Carcinoma

<p>Abstract</p> <p>Background</p> <p>Xenobiotic Metabolizing Enzymes (XMEs) contribute to the detoxification of numerous cancer therapy-induced products. This study investigated the susceptibility and prognostic implications of the CYP2E1, CYP2C19, CYP2D6, mEH and NAT2 gene polymorphisms in breast carcinoma patients.</p> <p>Methods</p> <p>The authors used polymerase chain reaction and restriction enzyme digestion to characterize the variation of the CYP2E1, CYP2C19, CYP2D6, mEH and NAT2 gene in a total of 560 unrelated subjects (246 controls and 314 patients).</p> <p>Results</p> <p>The mEH (C/C) mutant and the NAT2 slow acetylator genotypes were significantly associated with breast carcinoma risk (p = 0.02; p = 0.01, respectively). For NAT2 the association was more pronounced among postmenopausal patients (p = 0.006). A significant association was found between CYP2D6 (G/G) wild type and breast carcinoma risk only in postmenopausal patients (p = 0.04). Association studies of genetic markers with the rates of breast carcinoma specific overall survival (OVS) and the disease-free survival (DFS) revealed among all breast carcinoma patients no association to DFS but significant differences in OVS only with the mEH gene polymorphisms (p = 0.02). In addition, the mEH wild genotype showed a significant association with decreased OVS in patients with axillary lymph node-negative patients (p = 0.03) and with decreasesd DFS in patients with axillary lymph node-positive patients (p = 0.001). However, the NAT2 intermediate acetylator genotype was associated with decreased DFS in axillary lymph node-negative patients.</p> <p>Conclusion</p> <p>The present study may prove that polymorphisms of some XME genes may predict the onset of breast carcinoma as well as survival after treatment.</p

Le gisement mésolithique des Fieux (Miers, Lot) : une halte de chasse sur le causse de Gramat ?

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