Effect of progesterone as maintenance tocolytic therapy on the prevention of recurrent preterm labor: a randomized clinical trial

Objective: The study evaluated the efficacy and safety of vaginal rogesterone on prevention of recurrent preterm labor. Materials and methods: Total number of 70 patients with preterm labor treated with intravenous magnesium sulfate in perinatology department of valiasr hospital entered to a randomized clinical trial. Treatment group after inhibition of preterm labor with magnesium sulfate received progesterone suppository (400 mg) daily until delivery and control group received no treatment. Latency until delivery, recurrence of preterm labor and neonatal outcomes were studied. Statistical significance was defined as p< 0.05. Results: Mean latency until delivery (p< 0.05), low birth weight (p< 0.05), birth weight (p< 0.01) were significantly different between the two groups. Recurrence of preterm labor was not significantly different between the groups. Conclusions: The use of vaginal progesterone suppository after successful parenteral tocolysis associated with a longer latency preceding delivery but failed to reduce the incidence of recurrent preterm labor

Plasma lipids relationship with results of Oral Glucose Challenge Test in pregnancy

Objective: This study aimed to evaluate the correlation between plasma lipid levels at first trimester of pregnancy and results of Oral Glucose Challenge Test (OGCT). Materials and methods:  In a cross - sectional descriptive analytic study, two hundred eligible primigravida women without history of Diabetes Mellitus referring to Vali-e-Asr Hospital were evaluated. Plasma levels of triglyceride and cholesterol were measured at first trimester of pregnancy and Oral Glucose Challenge Test was done for all women at  24th - 28th gestational week. Pre-pregnancy BMI, and plasma levels of triglyceride and cholesterol at first trimester of pregnancy were compared with the results of OGCT. Results were analyzed using SPSS version 14. p-values ≤ 0.05 was considered statistically significant. Results: In 45 (22.5%) of the women OGCT was positive.  Pre pregnancy BMI and the rate of positive result for OGCT were both correlated with the plasma levels of triglyceride and cholesterol at first trimester of pregnancy. Conclusion: Plasma lipid levels in first trimester can predict the result of OGCT at 24- 28 weeks of pregnancy