DISRUPTING FACULTY SERVICE: USING TECHNOLOGY TO INCREASE ACADEMIC SERVICE PRODUCTIVITY

Scholarly attention regarding faculty involvement has primarily focused on faculty opinions of shared governance and faculty influence on institutional decision-making. There has been limited attention given to academic service productivity and the effectiveness of traditional approaches toward the accomplishment of faculty service requirements. This paper discusses disruptive technological change as a subset of disruptive innovation and proposes a technology-based framework for increasing service productivity while maintaining effort with regard to faculty service requirements in academic institutions. Specifically, a social networking tool is used to approach academic service projects with organic involvement and measured progress. It is suggested that such an approach may have positive implications toward increasing productivity in academic service. Further, additional benefits inherent in the tool make possible the leveraging of external networks for further productivity gains with no increase in resources while fostering a standardization of products across universities

The role of the university in accelerated learning and innovation as a regional ecosystem integrator

Purpose - The purpose of this paper is to present an adaptation of a program that is at the intersection of two dynamic force fields. The first relates to imperatives impinging upon and inherent in higher education. The second ties to the concept of ecosystems as spaces for aligning actors and resources to create value. Design/methodology/approach - Tables I-III present pre-test and post-test means and p-values for the paired sample t-tests for the measures. Findings - As expected, post-test means are consistently significantly higher (or lower depending on item wording) for a shift in beliefs away from self-censoring and prejudging ideas during ideation and more toward greater openness in the ideation process. Originality/value - The paper examines the outcome of an educational program

How patient are entrepreneurs?

This paper investigates the time preferences of entrepreneurs using U.S. cross section data from the 2001 Survey of Consumer Finances. The findings indicate that there is a statistically significant relationship between the rate of time preference of entrepreneurs and their age, years of education, and their degree of risk aversion. No statistically significant relationship was found between the rate of time preference of entrepreneurs and their networth and being female

Launching an Accelerated Online MBA Program: Assuring Quality with Scale, Based on Principles of Effective Course Design

This paper describes the challenges and advancements encountered by graduate faculty at a Midwestern public university as it transitioned to offering an accelerated MBA program with online, hybrid, and traditional courses, while experiencing 520% (from 100 to 620 students) growth over 24 months. Faculty consulted a ten-principle framework of course design to develop new courses for MBA concentrations and adjust teaching methods, assignment structures, student interactions, and teaching assistant integration to deliver a cutting-edge program in a competitive market. Case studies in deploying experiential learning in a fast-paced, large online classroom environment are discussed for three MBA courses

N-[C-11]Methyl-AMD3465 PET as a Tool for In Vivo Measurement of Chemokine Receptor 4 (CXCR4) Occupancy by Therapeutic Drugs

Chemokine receptor 4 (CXCR4) is overexpressed in many cancers and a potential drug target. We have recently developed the tracer N-[C-11]methyl-AMD3465 for imaging of CXCR4 expression by positron emission tomography (PET). We investigated the pharmacokinetics of N-[C-11]methyl-AMD3465 in rats bearing a C6 tumor and assessed whether the CXCR4 occupancy by the drug PlerixaforA (R) can be measured with this PET tracer. A subcutaneous C6 tumor was grown in Wistar rats. Dynamic N-[C-11]methyl-AMD3465 PET scans with arterial blood sampling was performed in control rats and rats pretreated with PlerixaforA (R) (30 mg/kg, s.c). The distribution volume (V (T)) of the tracer was estimated by compartment modeling with a two-tissue reversible compartment model (2TRCM) and by Logan graphical analysis. The non-displaceable binding potential (BPND) was estimated with the 2TRCM. Next, CXCR4 receptor occupancy of different doses of the drug PlerixaforA (R) (0.5-60 mg/kg) was investigated. The tumor could be clearly visualized by PET in control animals. Pretreatment with 30 mg/kg PlerixaforA (R) significantly reduced tumor uptake (SUV 0.65 +/- A 0.08 vs. 0.20 +/- A 0.01, p <0.05). N-[C-11]Methyl-AMD3465 was slowly metabolized in vivo, with 70 +/- A 7% of the tracer in plasma still being intact after 60 min. The tracer showed reversible in vivo binding to its receptor. Both 2TRCM modeling and Logan graphical analysis could be used to estimate V (T). Pre-treatment with 30 mg/kg PlerixaforA (R) resulted in a significant reduction in V (T) (2TCRM 0.87 +/- A 0.10 vs. 0.23 +/- A 0.12, p <0.05) and BPND (1.85 +/- A 0.14 vs. 0.87 +/- A 0.12, p <0.01). Receptor occupancy by PlerixaforA (R) was dose-dependent with an in vivo ED50 of 12.7 +/- A 4.0 mg/kg. Logan analysis gave comparable results. N-[C-11]Methyl-AMD3465 PET can be used to visualize CXCR4 expression and to calculate receptor occupancy. V (T) determined by Logan graphical analysis is a suitable parameter to assess CXCR4 receptor occupancy. This approach can easily be translated to humans and used for early drug development and optimization of drug dosing schedules