Ассоциация полиморфизма гена IL12Bс предрасположенностью к псориазу в популяцииСеверо-Западного региона России

The IL12B gene encodes protein р40 being a common subunit of interleukin-12 and interleukin-23 playing an important part in the pathogenesis of psoriasis. The IL12B gene has polymorphism rs12188300, which can be associated with the risk of psoriasis development. The goal of the study was to assess the distribution of alleles of polymorphism rs12188300 in psoriatic patients in the Northwestern region of Russia. Genotyping was carried out using the real-time allele-specific polymerase chain reaction. An increased occurrence of a rare allele T in psoriatic patients as compared to healthy people was observed (OR = 1.96, р = 0.0007). The occurrence of the rare allele T in patients with psoriatic arthritis was higher than in the control group (OR = 3.49, р = 0.005). These results suggest that rs12188300 polymorphism of the IL12B gene is a new genetic marker of psoriasis and psoriatic arthritis.Ген IL12B кодирует белок р40, являющийся общей субъединицей интерлейкина-12 и интерлейкина-23, играющих важную роль в патогенезе псориаза. Ген IL12B содержит полиморфизм rs12188300, который может быть ассоциирован с риском развития псориаза. Целью работы явилось изучение распределения аллелей полиморфизма rs12188300 у больных псориазом Северо-Западного региона России. Генотипирование проводилось методом аллельспецифической полимеразной цепной реакции в режиме реального времени. Выявлено повышение встречаемости редкого аллеля Т среди больных псориазом по сравнению со здоровыми лицами (OR = 1,96, р = 0,0007). Частота редкого аллеля Т среди больных псориатическим артритом была выше, чем в группе контроля (OR = 3,49, р = 0,005). Полученные результаты позволяют предположить, что полиморфизм rs12188300 гена IL12B является новым генетическим маркером псориаза и псориатического артрита

Current issues of mining activities on celestial bodies: International law aspects

[No abstract available

Planetary technology. Prerequisites for the formation of a new scientific discipline

The article considers the military-political confrontation in the “space race” between the USSR and the United States, which opened up historical prospects for scientific research and development of outer space. The assessment to new initiatives of the USA is given. Such initiatives that have not just returned the confrontation in the space sphere but have defined a new vector: commercial research of the mineral resources of celestial bodies; exploitation and utilization of space resources; an attempt to establish boundaries of commercial interests of the States on celestial bodies. An assessment of the development of the mining industry, indicating the intensification of mineral extraction and the impact of mining operations on the environment, is made. The paper also contains an analysis of emerging man-made disasters at mining enterprises and their impact on humans and the environment. It is suggested that the gradual depletion of Earth’s resources, the deterioration of the environmental situation in the locations where minerals are extracted, and a good knowledge of a number of space bodies that have unique reserves of mineral raw materials, makes the celestial bodies attractive for commercial development. The programs of various States in the field of development of celestial bodies and possible development of their mineral resources are analyzed. The article deals with the trends and concepts of further research in the field of space exploration, the commonality and difference of Geotechnology and the process of extracting minerals from celestial bodies. The mutual relationship between the development of the mineral resource base of celestial bodies and the development of several related Sciences is determined. The prerequisites for the possible formation of a new independent scientific direction are identified, and its stages are defined. It is suggested that it is possible to identify a new object of research and consider the extraction of minerals from space bodies as a separate science. It was also noted that due to the lack of industry planetary development and exploration of mineral resource base of the celestial bodies, the development of this science will be based on the analysis of experience and scientific knowledge obtained through research. After selecting the object of research, the subject of research and goals were also determined, as well as the relationship with other related Sciences was indicated. © 2020, Scientific and Industrial company 'Gemos Ltd.'. All rights reserved

Актуальные проблемы добычи природных ресурсов на небесных телах

This article deals with legal regulation of mining activities on the Moon and other celestial bodies. Outer Space Treaty 1967 and the Moon Agreement 1979 provisions relating to these activities are interpreted in different ways by the outer space participants, which does not contribute to a unified approach to the exploration, extraction and utilization of space resources. This article is aimed at finding a possible solution to the issue.Статья посвящена правовому регулированию деятельности по добычи полезных ископаемых на Луне и других небесных телах. Положения Договора по космосу 1967 г. и Соглашения о Луне 1979 г., касающиеся данной деятельности, толкуются участниками космической деятельности по-разному, что не способствует формированию единого подхода в отношении исследования, разработки и переработки космических ресурсов. Данная работа направлена на поиск возможного решения для урегулирования обозначенного вопроса

Stress-strain behavior control in rock mass using different-strength backfill

Transition of mining to deeper horizons, depletion of mineral reserves and complication of geological conditions can induce manmade disasters. To avoid the negative consequences of mineral mining, it is necessary to improve the ground control procedures for enhancement of mining safety, to introduce new engineering solutions that enable hybrid open pit/underground mining and to abate adverse impact of geotechnology on the local biological optimum. The analysis of the backfilling experience allows for the conclusion on the necessity of improvement and wider application of this technology as it makes it possible to level the disadvantages of other systems, promotes safety of mining operations and ensures more complete mineral extraction. The finite element-based stress-strain analysis of rock mass depending on the backfilling variant defines the variation range of stresses. The comparative studies into the parameters of the exposed backfill surfaces allow concluding on applicability of differentstrength backfill in mineral mining in difficult geological conditions. Based on using differentstrength backfill, the authors propose some engineering solutions capable to reduce the cost of backfilling operations at the maintained safety and completeness of mineral extraction in mining thin and moderately thick steeply dipping and flat ore bodies. © 2020 Publishing house Mining book. All rights reserved

Improvement of the backfilling characteristics by activation of halite waste for non-waste geotechnology

To reduce the frequency of man-made disasters it is recommended to use development of deposits systems with backfilling of working space at potash mines. The use of halite enrichment waste in the filing mixture is proposed in order to improve the technical and economic indicators of the mine and the environmental situation in the mining area. The factors influencing the choice of development technology with artificial maintaining of winning area are considered. The advantages and disadvantages of using the technology of the backfilling are indicated. Aspects of preparation of hardening backfill and questions of improvement of its quality by disintegration activation of components are revealed. The possibility of activation of halite enrichment waste used as an inert aggregate in disintegrators is considered. © Published under licence by IOP Publishing Ltd