Protective Effects of Hydroxytyrosol on Renal Ischemia-reperfusion Injury in Mice

Background: Renal ischemia reperfusion (IR), one of the most important causative mechanisms of acute kidney injury, is a major clinical problem that occurs in some hospitalized patients. The aim of this study was to investigate the effects of hydroxytyrosol (HT) on renal ischemia-reperfusion injury in mice.Methods: Male mice were randomly assigned to three groups (N = 9): (1) sham operated, (2) renal IR (45 min ischemia followed by 24 h reperfusion), or (3) renal IR+HT (5 mg/kg orally for 7 days before renal IR and one hour before IR). Animals were sacrificed and the blood and kidney tissue samples were collected for glutathione (GSH) and malondialdehyde (MDA) evaluation.Results: Renal IR injury led to decreases in renal tissue GSH and increases in MDA levels compared to sham operated. Hydroxytyrosol partially inhibited the IR-induced decrease in GSH activity. In addition, in the renal IR+HT group, MDA was increased compared to the renal IR group.Conclusions: These findings suggest that HT diminished oxidative stress in renal tissue after renal IR

Protective Effects of Hydroxytyrosol on Renal Ischemia-reperfusion Injury in Mice

Background: Renal ischemia reperfusion (IR), one of the most important causative mechanisms of acute kidney injury, is a major clinical problem that occurs in some hospitalized patients. The aim of this study was to investigate the effects of hydroxytyrosol (HT) on renal ischemia-reperfusion injury in mice.Methods: Male mice were randomly assigned to three groups (N = 9): (1) sham operated, (2) renal IR (45 min ischemia followed by 24 h reperfusion), or (3) renal IR+HT (5 mg/kg orally for 7 days before renal IR and one hour before IR). Animals were sacrificed and the blood and kidney tissue samples were collected for glutathione (GSH) and malondialdehyde (MDA) evaluation.Results: Renal IR injury led to decreases in renal tissue GSH and increases in MDA levels compared to sham operated. Hydroxytyrosol partially inhibited the IR-induced decrease in GSH activity. In addition, in the renal IR+HT group, MDA was increased compared to the renal IR group.Conclusions: These findings suggest that HT diminished oxidative stress in renal tissue after renal IR

Evaluation of the Hypophysial-testicular Axis and Testis Tissues after Matricaria Chamomilla Consumption in Rats

Background: Matricaria chamomilla is an ancient herbal drug widely consumed to sexual system improvement. The aim of this research was to study the effect of Matricaria chamomilla hydroalcholic extract on the pituitary-testis axis and testes tissues of male rats.Methods: Mature male rats were randomly assigned to two groups: the Matricaria group (100 mg/kg of Matricaria chamomilla extract via feeding tube once daily for 8 weeks) and the control group (1 ml of distilled water orally for the same period). After 8 weeks, animal were evaluated for blood levels of testosterone, estrogen, FSH, and LH. Fertility indices like sperm count and the weight of the reproductive organs were assayed. In addition, testes histological assessments were done.Results: Consumption of Matricaria caused elevation in blood testosterone, FSH an LH. Spermatogonia, Spermatocyte, Spermatid, Spermatozoa, Leydig and Epididymal spermatozoa reserve count and reproductive organs weight were increased too.Conclusions: These findings suggest that Matricaria chamomilla extract improve pituitary-testis axis and spermatogenesis in rats.

Evaluation of the Hypophysial-testicular Axis and Testis Tissues after Matricaria Chamomilla Consumption in Rats

Background: Matricaria chamomilla is an ancient herbal drug widely consumed to sexual system improvement. The aim of this research was to study the effect of Matricaria chamomilla hydroalcholic extract on the pituitary-testis axis and testes tissues of male rats.Methods: Mature male rats were randomly assigned to two groups: the Matricaria group (100 mg/kg of Matricaria chamomilla extract via feeding tube once daily for 8 weeks) and the control group (1 ml of distilled water orally for the same period). After 8 weeks, animal were evaluated for blood levels of testosterone, estrogen, FSH, and LH. Fertility indices like sperm count and the weight of the reproductive organs were assayed. In addition, testes histological assessments were done.Results: Consumption of Matricaria caused elevation in blood testosterone, FSH an LH. Spermatogonia, Spermatocyte, Spermatid, Spermatozoa, Leydig and Epididymal spermatozoa reserve count and reproductive organs weight were increased too.Conclusions: These findings suggest that Matricaria chamomilla extract improve pituitary-testis axis and spermatogenesis in rats.

Effectiveness of Multi-Faceted Training Focused on Spiritual Parenting to Mothers on Promoting Spirituality of Overweight Children

Background: Growing evidences show that the successful treatment of pediatric obesity requires consideration not only of medical issues but also of psychological and social environmental and familial factors. Special emphasis is given to the psychological and spiritual aspects of pediatric obesity in the context of a holistic perspective. In this regard this study was conducted to determine the effectiveness of multi-faceted training focused on spiritual parenting to mothers on promoting spirituality of overweight children.Methods: In this study, 48 volunteer (24 boy students and 24 their mothers) eligible to exclude-include criteria were selected and randomly assigned into two experimental and control groups. An orientation session was held to explain the research goals and intervention. The experimental group trained, 90 minutes sessions weekly for 3 months (10 sessions), but control group did not receive any intervention. Prior to and after Training, all participant completed demographic information questionnaire and then children completed religiosity and spirituality scale for youth (rassy) scale and childrens' BMI were measured. Data analysis with 22th version of SPSS was done.Results: Data analysis with applying one-way and multivariate analysis of covariance ( ancova and mancova) revealed that Multi-faceted training focused on spiritual parenting could significantly promote the total score and faith-based coping and religious social support/activities but BMI were decreased significantly (P<0.05). Conclusions: The results showed that the multi-faceted training focused on spiritual parenting to mothers leads to promotion of spirituality scores of children with overweight. Also, it seems that the body mass index (BMI) will be reduced. This study demonstrated that spiritual parenting benefits are similar to the dietary restriction and physical activity. And it can cause weight loss and enhance spirituality in children

Effectiveness of Multi-Faceted Training Focused on Spiritual Parenting to Mothers on Promoting Spirituality of Overweight Children

Background: Growing evidences show that the successful treatment of pediatric obesity requires consideration not only of medical issues but also of psychological and social environmental and familial factors. Special emphasis is given to the psychological and spiritual aspects of pediatric obesity in the context of a holistic perspective. In this regard this study was conducted to determine the effectiveness of multi-faceted training focused on spiritual parenting to mothers on promoting spirituality of overweight children.Methods: In this study, 48 volunteer (24 boy students and 24 their mothers) eligible to exclude-include criteria were selected and randomly assigned into two experimental and control groups. An orientation session was held to explain the research goals and intervention. The experimental group trained, 90 minutes sessions weekly for 3 months (10 sessions), but control group did not receive any intervention. Prior to and after Training, all participant completed demographic information questionnaire and then children completed religiosity and spirituality scale for youth (rassy) scale and childrens' BMI were measured. Data analysis with 22th version of SPSS was done.Results: Data analysis with applying one-way and multivariate analysis of covariance ( ancova and mancova) revealed that Multi-faceted training focused on spiritual parenting could significantly promote the total score and faith-based coping and religious social support/activities but BMI were decreased significantly (P<0.05). Conclusions: The results showed that the multi-faceted training focused on spiritual parenting to mothers leads to promotion of spirituality scores of children with overweight. Also, it seems that the body mass index (BMI) will be reduced. This study demonstrated that spiritual parenting benefits are similar to the dietary restriction and physical activity. And it can cause weight loss and enhance spirituality in children