Public Sector Innovation: Case Study of e-government Projects in Pakistan

This study analyses and examines in detail the impact of public sector innovation to improve public satisfaction level, it is about changing the traditional government into a more integrated and efficient one. Innovation is actually the engine of economic growth. Innovation in the public sector is an under-researched area. It deals with governance, political and human issues which are very difficult to solve. Since much of the topic and studies on innovation are focusing on the private sector, it is the aim of this study to analyse the process of innovation, mainly in Information and Communication Technology (ICT) in the public sector. This study will eventually be able to give e-government model/ guidelines that encapsulates the reality of innovation by the government. Innovation in government is not only about bringing a new breakthrough product to the people, but also to bring in changes to the culture in the organisation, the way a decision is made, and perhaps more importantly, how it can use technology to strengthen its role as the provider of social and economic welfare to the people. This study has also compared the findings of the e-government case study to the literature of innovation mainly in the area of process innovation. There is SWOT analysis with weight rating to judge the e-governance challenges, which Pakistan is facing as a developing nation. The study concludes that the public sector needs to overcome its traditional characteristics of poor agenda setting, unclear objectives, lack of transparency, and bureaucratic layers of decision-making processes. Keywords: Citizens, e-government Projects, ICT, Public Satisfaction, Public Sector Innovatio

Performance Measurement: A Conceptual Framework for Supply Chain Practices

AbstractMe--asurement of Supply Chain (SC) performance with regards to key practices of SC paradigms is the area which is under research. Presently there are no guidance or set rules under which we can measure SC performance. The lack of clarity and comparability concerns in this area creates misunderstanding and makes it more difficult to formulate a clear strategy. The aim of this research is to identify antecedents of existing SC paradigm's practices, as well as antecedents for SC performance measurement to formulate a conceptual framework. Based on this research, new sustainable SC performance measurement conceptual framework is proposed for existing SC paradigms. The detailed analysis presented in this research paper offers a set of characteristics and structure that industry as well as academia could use it as a guidance framework to measure SC performance

Investigation of tool wear and energy consumption in machining Ti6Al4V alloy with uncoated tools.

This research studies the energy consumption and wear mechanism of carbide cutting tools in dry machining of Ti6Al4V alloy. In the first phase of experiments, full factorial design experiments were employed to study the tool wear rate (R) and specific cutting energy (SCE) with respect to the machining conditions (cutting speed and feed rate). Results showed that machining responses such as tool wear and energy consumption are affected by cutting conditions, thus requiring investigation to understand the wear mechanisms. Therefore, in the second phase, additional experiments were performed to investigate the tool-workpiece interactions at the cutting conditions reported to have low, moderate, and high tool wear. It was revealed that strong adhesion and material transfer between the tool and workpiece caused high wear. Electron dispersive X-ray spectroscopy (EDX) analysis of worn tools showed that the transfer of tungsten (W) and cobalt (Co) to the workpiece and titanium to the tool surface is the primary cause of tool deterioration. As a result, diffusion and dissolution have degraded cutting performance and weakened the tool edge, leading to rapid wear. Furthermore, worn tools resulted in relatively higher energy consumption per unit volume of material removed at the tooltip. The degradation of cutting performance and weakening of the tool edge results in rapid wear and higher energy consumption. The study suggests that minimizing tool wear is crucial for energy reduction, improved sustainability, and cleaner production goals in dry machining of titanium-based alloys

Emergency Calls in the City of Vaughan (Canada) During the COVID-19 Pandemic: A Spatiotemporal Analysis

[EN] The COVID-19 pandemic has required governments to introduce various public health measures in order to contain and manage the pandemic’s unprecedented impacts in terms of illnesses and deaths. This study analyzes the spatiotemporal distribution of emergency incidents in Vaughan, a medium-sized city in the Canadian province of Ontario, comparing occurrences prior to and during the pandemic. Emergency calls received and responded to by the Vaughan Fire and Rescue Service were examined using spatial density and emerging hotspot analysis based on 11 periods of various public health measures and restrictions set in place from 17 March 2020 to 15 July 2021, as compared with corresponding pre-pandemic periods in the preceding three years (2017-2019). The resulting analyses show significant spatiotemporal changes in emergency incident patterns, particularly during periods of more stringent public health measures such as ‘stay at home’ orders or lockdowns of nonessential business establishments. Results of the study could provide useful insights for managing emergency service resources and operations during public health emergencies.This research has been conducted with financial support from the Social Sciences and Humanities Research Council of Canada (SSHRC) as part of its Partnership Engage Grants (PEG) COVID-19 Special Initiative. The Vaughan Fire and Rescue Service is the partner organization of the York University research team in this effort. The research work has been also supported by ADERSIM, funded by Ontario Research Fund (ORF).Asgary, A.; Solis, A.; Khan, N.; Wimaladasa, J.; Sabet, M. (2022). Emergency Calls in the City of Vaughan (Canada) During the COVID-19 Pandemic: A Spatiotemporal Analysis. En 4th International Conference on Advanced Research Methods and Analytics (CARMA 2022). Editorial Universitat Politècnica de València. 197-204. https://doi.org/10.4995/CARMA2022.2022.1508719720

Technical and Quality Standards and Practices in Healthcare Facilities

This paper presents the highlights of many technical standards, as established by International Organization for Standardization (ISO) through International Classification for Standards (ICS) and British Standards (BS), and quality standards and practices as governed by some international, regional or national institutes in promoting patients rights and safety control in medical sciences and healthcare facilities. The paper draws attention to adopt these standards in Pakistan

The Center for Innovations in Business and Management Practice Analysis of factors affecting the customer satisfaction level of public sector in developing countries: an empirical study of automotive repair service quality in Pakistan Minitab 15, Six Sigm

Abstract This paper aims to investigate the factors which mainly affect the customer satisfaction level of automotive repair service quality being provided by the public sector organizations in Pakistan. A questionnaire was designed to measure the gap between the customer expectations and satisfaction about repair service quality. A total of 183 managers, supervisors and operators randomly selected from 100 customer organizations (public sector) responded to the questionnaire. Randomly collected data analyzed using software SPSS 19

Alterations in T and B cell function persist in convalescent COVID-19 patients

BackgroundEmerging studies indicate that some COVID-19 patients suffer from persistent symptoms including breathlessness and chronic fatigue; however the long-term immune response in these patients presently remains ill-defined.MethodsHere we describe the phenotypic and functional characteristics of B and T cells in hospitalised COVID-19 patients during acute disease and at 3-6 months of convalescence.FindingsWe report that the alterations in B cell subsets observed in acute COVID-19 patients were largely recovered in convalescent patients. In contrast, T cells from convalescent patients displayed continued alterations with persistence of a cytotoxic programme evident in CD8+ T cells as well as elevated production of type-1 cytokines and IL-17. Interestingly, B cells from patients with acute COVID-19 displayed an IL-6/IL-10 cytokine imbalance in response to toll-like receptor activation, skewed towards a pro-inflammatory phenotype. Whereas the frequency of IL-6+ B cells was restored in convalescent patients irrespective of clinical outcome, recovery of IL-10+ B cells was associated with resolution of lung pathology.ConclusionsOur data detail lymphocyte alterations in previously hospitalized COVID-19 patients up to 6 months following hospital discharge and identify 3 subgroups of convalescent patients based on distinct lymphocyte phenotypes, with one subgroup associated with poorer clinical outcome. We propose that alterations in B and T cell function following hospitalisation with COVID-19 could impact longer term immunity and contribute to some persistent symptoms observed in convalescent COVID-19 patients

World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions

BACKGROUND: To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, validation, and illustration of the revised WHO cardiovascular disease risk prediction charts that have been adapted to the circumstances of 21 global regions. METHODS: In this model revision initiative, we derived 10-year risk prediction models for fatal and non-fatal cardiovascular disease (ie, myocardial infarction and stroke) using individual participant data from the Emerging Risk Factors Collaboration. Models included information on age, smoking status, systolic blood pressure, history of diabetes, and total cholesterol. For derivation, we included participants aged 40-80 years without a known baseline history of cardiovascular disease, who were followed up until the first myocardial infarction, fatal coronary heart disease, or stroke event. We recalibrated models using age-specific and sex-specific incidences and risk factor values available from 21 global regions. For external validation, we analysed individual participant data from studies distinct from those used in model derivation. We illustrated models by analysing data on a further 123 743 individuals from surveys in 79 countries collected with the WHO STEPwise Approach to Surveillance. FINDINGS: Our risk model derivation involved 376 177 individuals from 85 cohorts, and 19 333 incident cardiovascular events recorded during 10 years of follow-up. The derived risk prediction models discriminated well in external validation cohorts (19 cohorts, 1 096 061 individuals, 25 950 cardiovascular disease events), with Harrell's C indices ranging from 0·685 (95% CI 0·629-0·741) to 0·833 (0·783-0·882). For a given risk factor profile, we found substantial variation across global regions in the estimated 10-year predicted risk. For example, estimated cardiovascular disease risk for a 60-year-old male smoker without diabetes and with systolic blood pressure of 140 mm Hg and total cholesterol of 5 mmol/L ranged from 11% in Andean Latin America to 30% in central Asia. When applied to data from 79 countries (mostly low-income and middle-income countries), the proportion of individuals aged 40-64 years estimated to be at greater than 20% risk ranged from less than 1% in Uganda to more than 16% in Egypt. INTERPRETATION: We have derived, calibrated, and validated new WHO risk prediction models to estimate cardiovascular disease risk in 21 Global Burden of Disease regions. The widespread use of these models could enhance the accuracy, practicability, and sustainability of efforts to reduce the burden of cardiovascular disease worldwide. FUNDING: World Health Organization, British Heart Foundation (BHF), BHF Cambridge Centre for Research Excellence, UK Medical Research Council, and National Institute for Health Research

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

A novel formulation of inhaled sodium cromoglicate (PA101) in idiopathic pulmonary fibrosis and chronic cough: a randomised, double-blind, proof-of-concept, phase 2 trial

Background Cough can be a debilitating symptom of idiopathic pulmonary fibrosis (IPF) and is difficult to treat. PA101 is a novel formulation of sodium cromoglicate delivered via a high-efficiency eFlow nebuliser that achieves significantly higher drug deposition in the lung compared with the existing formulations. We aimed to test the efficacy and safety of inhaled PA101 in patients with IPF and chronic cough and, to explore the antitussive mechanism of PA101, patients with chronic idiopathic cough (CIC) were also studied. Methods This pilot, proof-of-concept study consisted of a randomised, double-blind, placebo-controlled trial in patients with IPF and chronic cough and a parallel study of similar design in patients with CIC. Participants with IPF and chronic cough recruited from seven centres in the UK and the Netherlands were randomly assigned (1:1, using a computer-generated randomisation schedule) by site staff to receive PA101 (40 mg) or matching placebo three times a day via oral inhalation for 2 weeks, followed by a 2 week washout, and then crossed over to the other arm. Study participants, investigators, study staff, and the sponsor were masked to group assignment until all participants had completed the study. The primary efficacy endpoint was change from baseline in objective daytime cough frequency (from 24 h acoustic recording, Leicester Cough Monitor). The primary efficacy analysis included all participants who received at least one dose of study drug and had at least one post-baseline efficacy measurement. Safety analysis included all those who took at least one dose of study drug. In the second cohort, participants with CIC were randomly assigned in a study across four centres with similar design and endpoints. The study was registered with ClinicalTrials.gov (NCT02412020) and the EU Clinical Trials Register (EudraCT Number 2014-004025-40) and both cohorts are closed to new participants. Findings Between Feb 13, 2015, and Feb 2, 2016, 24 participants with IPF were randomly assigned to treatment groups. 28 participants with CIC were enrolled during the same period and 27 received study treatment. In patients with IPF, PA101 reduced daytime cough frequency by 31·1% at day 14 compared with placebo; daytime cough frequency decreased from a mean 55 (SD 55) coughs per h at baseline to 39 (29) coughs per h at day 14 following treatment with PA101, versus 51 (37) coughs per h at baseline to 52 (40) cough per h following placebo treatment (ratio of least-squares [LS] means 0·67, 95% CI 0·48–0·94, p=0·0241). By contrast, no treatment benefit for PA101 was observed in the CIC cohort; mean reduction of daytime cough frequency at day 14 for PA101 adjusted for placebo was 6·2% (ratio of LS means 1·27, 0·78–2·06, p=0·31). PA101 was well tolerated in both cohorts. The incidence of adverse events was similar between PA101 and placebo treatments, most adverse events were mild in severity, and no severe adverse events or serious adverse events were reported. Interpretation This study suggests that the mechanism of cough in IPF might be disease specific. Inhaled PA101 could be a treatment option for chronic cough in patients with IPF and warrants further investigation