Mid-Infrared Spectroscopy of Optically Faint Extragalactic 70 micron Sources

We present mid-infrared spectra of sixteen optically faint sources with 70 micron fluxes in the range 19-38mJy. The sample spans a redshift range of 0.35<z<1.9, with most lying between 0.8<z<1.6, and has infrared luminosities of 10^{12} - 10^{13} solar luminosities. Ten of 16 objects show prominent polycyclic aromatic hydrocarbon (PAH) emission features; four of 16 show weak PAHs and strong silicate absorption, and two objects have no discernable spectral features. Compared to samples with 24 micron fluxes >10mJy, the 70\um sample has steeper IR continua and higher luminosities. The PAH dominated sources are among the brightest starbursts seen at any redshift, and reside in a redshift range where other selection methods turn up relatively few sources. The absorbed sources are at higher redshifts and have higher luminosities than the PAH dominated sources, and may show weaker luminosity evolution. We conclude that a 70 micron selection extending to ~20mJy, in combination with selections at mid-IR and far-IR wavelengths, is necessary to obtain a complete picture of the evolution of IR-luminous galaxies over 0<z<2.Comment: ApJ accepte

The Submillimetre Properties of Ultraluminous Infrared Galaxies

We present the results of SCUBA observations of a complete sample of local ULIRGs. Twenty of the initial sample of 23 sources are detected at 850 um and nearly half of the objects are also detected at 450 um. This data is combined with existing observations of a further seven ULIRGs to produce the largest sample of submm observations of ULIRGs currently available. We use similar techniques to the SLUGS survey to fit dust spectral energy distributions (SEDs) to their far-IR emission. We find that ULIRGs have a higher dust temperature than lower luminosity objects (42K compared to 35K) and a steeper emissivity index. For those objects where 450 um fluxes are available we also attempt a two component dust SED fit, with warm and cool dust and a dust emissivity index of beta=2. Such a model has been found to be a good fit to lower luminosity systems. We find that it also works well for ULIRGs, but that ULIRGs have a smaller cold dust component. Comparison of the dust mass derived for ULIRGs and more normal spiral galaxies suggests that the dust content of a ULIRG is simply the combined dust content of the two galaxies whose merger has triggered the ULIRG activity. We examine the high end of the 850 um luminosity function and find results consistent with those of the earlier SLUGS survey. We also find that ULIRGs make up only about 50% of the high end of the 850 um luminosity function, with LIRGs containing a large mass of cool dust likely to be responsible for the rest.Comment: Accepted for publication in MNRA

Detection of the in vitro modulation of Plasmodium falciparum Arf1 by Sec7 and ArfGAP domains using a colorimetric plate-based assay:

The regulation of human Arf1 GTPase activity by ArfGEFs that stimulate GDP/GTP exchange and ArfGAPs that mediate GTP hydrolysis has attracted attention for the discovery of Arf1 inhibitors as potential anti-cancer agents. The malaria parasite Plasmodium falciparum encodes a Sec7 domain-containing protein - presumably an ArfGEF - and two putative ArfGAPs, as well as an Arf1 homologue (PfArf1) that is essential for blood-stage parasite viability. However, ArfGEF and ArfGAP-mediated activation/deactivation of PfArf1 has not been demonstrated

A SPITZER -SELECTED GALAXY CLUSTER AT z = 1.62

We report the discovery of a galaxy cluster at z = 1.62 located in the Spitzer Wide-Area Infrared Extragalactic survey XMM-LSS field. This structure was selected solely as an overdensity of galaxies with red Spitzer/Infrared Array Camera colors, satisfying ([3.6] - [4.5])AB> - 0.1 mag. Photometric redshifts derived from the Subaru XMM Deep Survey (BViz bands), the UKIRT Infrared Deep Survey-Ultra-Deep Survey (UKIDSS-UDS, JK bands), and from the Spitzer Public UDS survey (3.6-8.0 μm) show that this cluster corresponds to a surface density of galaxies at z ≈ 1.6 that is >20σ above the mean at this redshift. We obtained optical spectroscopic observations of galaxies in the cluster region using IMACS on the Magellan telescope. We measured redshifts for seven galaxies in the range z = 1.62-1.63 within 2.8 arcmin (1.7 mag. The photometric-redshift probability distributions for the red galaxies are strongly peaked at z = 1.62, coincident with the spectroscopically confirmed galaxies. The rest-frame (U - B) color and scatter of galaxies on the red sequence are consistent with a mean luminosity-weighted age of 1.2 ± 0.1 Gyr, yielding a formation redshift \overline{z_f}=2.35 \, \pm \, 0.10, and corresponding to the last significant star formation period in these galaxies. This work is based in part on observations made with the Spitzer Space Telescope, which is operated by the Jet Propulsion Laboratory, California Institute of Technology, under NASA contract 1407. This paper also includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile. This work is based in part on data collected at Subaru Telescope, which is operated by the National Astronomical Observatory of Japan

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Increasing frailty is associated with higher prevalence and reduced recognition of delirium in older hospitalised inpatients: results of a multi-centre study

Purpose: Delirium is a neuropsychiatric disorder delineated by an acute change in cognition, attention, and consciousness. It is common, particularly in older adults, but poorly recognised. Frailty is the accumulation of deficits conferring an increased risk of adverse outcomes. We set out to determine how severity of frailty, as measured using the CFS, affected delirium rates, and recognition in hospitalised older people in the United Kingdom. Methods: Adults over 65 years were included in an observational multi-centre audit across UK hospitals, two prospective rounds, and one retrospective note review. Clinical Frailty Scale (CFS), delirium status, and 30-day outcomes were recorded. Results: The overall prevalence of delirium was 16.3% (483). Patients with delirium were more frail than patients without delirium (median CFS 6 vs 4). The risk of delirium was greater with increasing frailty [OR 2.9 (1.8–4.6) in CFS 4 vs 1–3; OR 12.4 (6.2–24.5) in CFS 8 vs 1–3]. Higher CFS was associated with reduced recognition of delirium (OR of 0.7 (0.3–1.9) in CFS 4 compared to 0.2 (0.1–0.7) in CFS 8). These risks were both independent of age and dementia. Conclusion: We have demonstrated an incremental increase in risk of delirium with increasing frailty. This has important clinical implications, suggesting that frailty may provide a more nuanced measure of vulnerability to delirium and poor outcomes. However, the most frail patients are least likely to have their delirium diagnosed and there is a significant lack of research into the underlying pathophysiology of both of these common geriatric syndromes

In vitro antifungal activity of hydroxychavicol isolated from Piper betle L

Background: Hydroxychavicol, isolated from the chloroform extraction of the aqueous leaf extract of Piper betle L., (Piperaceae) was investigated for its antifungal activity against 124 strains of selected fungi. The leaves of this plant have been long in use tropical countries for the preparation of traditional herbal remedies. Methods: The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of hydroxychavicol were determined by using broth microdilution method following CLSI guidelines. Time kill curve studies,post-antifungal effects and mutation prevention concentrations were determined against Candida species and Aspergillus species “respectively”. Hydroxychavicol was also tested for its potential to inhibit and reduce the formation of Candida albicans biofilms. The membrane permeability was measured by the uptake of propidium iodide. Results: Hydroxychavicol exhibited inhibitory effect on fungal species of clinical significance, with the MICs ranging from 15.62 to 500 μg/ml for yeasts, 125 to 500 μg/ml for Aspergillus species, and 7.81 to 62.5 μg/ml for dermatophytes where as the MFCs were found to be similar or two fold greater than the MICs. There was concentration-dependent killing of Candida albicans and Candida glabrata up to 8 × MIC. Hydroxychavicol also exhibited an extended post antifungal effect of 6.25 to 8.70 h at 4 × MIC for Candida species and suppressed the emergence of mutants of the fungal species tested at 2 × to 8 × MIC concentration. Furthermore, it also inhibited the growth of biofilm generated by C. albicans and reduced the preformed biofilms. There was increased uptake of propidium iodide by C. albicans cells when exposed to hydroxychavicol thus indicating that the membrane disruption could be the probable mode of action of hydroxychavicol. Conclusions: The antifungal activity exhibited by this compound warrants its use as an antifungal agent particularly for treating topical infections, as well as gargle mouthwash against oral Candida infections