Prolonged subfebrile condition in children. Possible causes, diagnostics

Prolonged subfebrile condition (PSC) is a complex diagnostic and therapeutic problem caused by a wide variety of reasons, which often require a wide and expensive examination, consultations of various specialists, and repeated hospitalizations. Most often, PSC is associated with infections, some non-infectious diseases (predominantly connective tissue) and growths. To infectious causes of DS include: acute respiratory viral infections, herpes virus infections, toxoplasmosis, chlamydia, borreliosis, bartonellosis, etc. Separately, “psychogenic fevers”, subfebrile condition associated with taking drugs, and artifical subfebrile condition are distinguished. The condition of the children, as a rule, is benign and in most cases goes away on their own within 6-24 months

Monozygous twins with Epstein–Barr infection in the nasopharynx

© 2020 National Academy of Pediatric Science and Innovation. All rights reserved. The article describes a clinical case of monozygotic twins with hypertrophy of the organs of the lymphopharyngeal ring. The examination revealed IgG to the Epstein–Barr virus capsid antigen in both patients. One twin had Epstein–Barr virus DNA in the sample from the oropharynx. It was this child who had complaints typical of patients with adenoid vegetation, and he required surgical treatment (endoscopic shaver adenotomy and radio wave bilateral tonsillotomy). At the time of the initial examination and in the absence of complaints the second twin revealed no DNA of Epstein–Barr virus in the oropharynx. This patient was diagnosed with adenoids of 1–2 degree. Due to the complaints of the second twin that appeared during the following year of observation, with previously negative results on active Epstein–Barr virus markers served as the reason for a repeated specific laboratory examination. Epstein-Barr virus DNA was found in a sample from this child’s oropharynx. This case using the twin control method by partner enabled us to demonstrate the significance of Epstein–Barr virus in the pathogenesis and clinic manifestations of chronic diseases of the lymphopharyngeal ring organs in children