Dehydro­leucodin: a guaiane-type sesquiterpene lactone

Dehydro­leucodin [systematic name: (1S,6S,2R)-9,13-dimeth­yl-5-methyl­ene-3-oxatricyclo­[8.3.0.02,6]trideca-9,12-diene-4,11-dione], C15H16O3, is a guanolide isolated from Artemisia douglasiana. The fused-ring system contains a seven-membered ring that adopts a chair conformation, a fused planar cyclo­pentenone ring and a five-membered lactone ring fused in envelope conformation. The absolute structure determined by X-ray analysis agrees with that previously assigned to this compound by NMR studies [Bohlmann & Zdero (1972 ▶). Tetra­hedron Lett. 13, 621–624] and also with that of leucodine, a closely related guaianolide [Martinez et al. (1988 ▶). J. Nat. Prod. 51, 221–228]

A phase II randomized trial comparing radiotherapy with concurrent weekly cisplatin or weekly paclitaxel in patients with advanced cervical cancer

<p>Abstract</p> <p>Purpose/Objective</p> <p>This is a prospective comparison of weekly cisplatin to weekly paclitaxel as concurrent chemotherapy with standard radiotherapy for locally advanced cervical carcinoma.</p> <p>Materials/Methods</p> <p>Between May 2000 and May 2004, 31 women with FIGO stage IB2-IVA cervical cancer or with postsurgical pelvic recurrence were enrolled into this phase II study and randomized to receive on a weekly basis either 40 mg/m²Cisplatin (group I; 16 patients) or 50 mg/m²paclitaxel (group II; 15 patients) concurrently with radiotherapy. Median total dose to point A was 74 Gy (range: 66-92 Gy) for group I and 66 Gy (range: 40-98 Gy) for group II. Median follow-up time was 46 months.</p> <p>Results</p> <p>Patient and tumor characteristics were similar in both groups. The mean number of chemotherapy cycles was also comparable with 87% and 80% of patients receiving at least 4 doses in groups I and II, respectively. Seven patients (44%) of group I and 8 patients (53%) of group II developed tumor recurrence. The Median Survival time was not reached for Group I and 53 months for group II. The proportion of patients surviving at 2 and 5 years was 78% and 54% for group I and 73% and 43% for group II respectively.</p> <p>Conclusions</p> <p>This small prospective study shows that weekly paclitaxel does not provide any clinical advantage over weekly cisplatin for concurrent chemoradiation for advanced carcinoma of the cervix.</p

Di-&#956;-azido-diazidodi-&#956;-oxalato-dihistaminetetracopper(II) 0.9-hydrate

The title compound, [Cu4(C2O4)2(N3)4(C5H9N3)2]&#183;0.9H2O, contains a tetranuclear CuII-based molecule composed of two oxalate-bridged CuII dimers linked through end-on azide ions and related by an inversion center. The tetranuclear unit contains two crystallographically independent CuII ions. One CuII ion coordinates to two N atoms of a histamine molecule, two O atoms of a bridging oxalate ligand, and an N atom of an end-on bridging azide ligand, leading to an elongated square-pyramidal coordination geometry in which the azide ion occupies the axial position. The other CuII ion, which has a square-planar coordination geometry, is coordinated by two O atoms of a bridging oxalate ligand and two N atoms of two different azide ligands, one which is bridging. In the crystal, a two-dimensional network parallel to (010) is formed by N&#8212;H...N and N&#8212;H...O hydrogen bonds. A partially occupied solvent water molecule refined to an occupancy of 0.447&#8197;(5). Two of the azide ligands were refined as disordered over two sets of sites with refined occupancies in the ratios 0.517&#8197;(8):0.483&#8197;(8) and 0.553&#8197;(5):0.447&#8197;(5)

Crystal structure of catena-poly[bis(tetraethylammonium) [tetraaquatris(μ-dicyanamido-κ2N1:N5)bis(dicyanamido-κN1)dicobaltate(II)] dicyanamide]

The structure of the title compound, [N(C2H5)4]2[Co2(C2N3)5(H2O)4](C2N3), is a new example of a metal–dicyanamide coordination polymer which exhibits a unique three-dimensional framework of covalently linked CoII chains. All bridging dicyanamide ligands in the title structure are in the μ1,5-bridging mode. The anionic CoII-dicyanamide network is templated by tetraethylammonium cations residing in a series of channels extending along the b axis where additional non-coordinating dicyanamidate anions are also located. The framework structure is further stabilized by O—H...N hydrogen bonding between aqua ligands and dicyanamido ligands or the dicyanamide anion. In addition, C—H...N interactions are present between the tetraethylammonium cations and dicyanamide amide nitrogen atoms

Synthesis And Characterization Of N\u3csup\u3e1\u3c/sup\u3e-(4-Toluenesulfonyl)-N\u3csup\u3e1\u3c/sup\u3e-(9-Anthracenemethyl)Triamines

A modular synthetic approach was developed to access triamines with varying tether lengths from commercially available aminoalkanols. Initial N-alkylation via reductive amination with anthracene-9-carbaldehyde provided the secondary amines in good yield. Subsequent ditosylation with excess TsC1 yielded the respective bis-N,O-tosylates. The tosylates were reacted with excess putrescine to give the final triamines. X-ray crystallography revealed that the polyamine tail is preferentially oriented over the shielding cone of the anthracene ring