Synthesis of certain 8-quinolyloxy and/or carbocyclic nitrogenous compounds for microbiological testing

Two new series as azosalicylic acid derivatives IVa-l and Va-c in addition to three series containing 8-quinolyloxy moiety Xa-i, XIIa-n and XIVa-e were synthesized for evaluation as antimicrobial compounds. Structures of the newly synthesized compounds have been deduced on the basis of elemental analysis and spectral data. Antimicrobial activity evaluation was carried using agar dilution technique; there was variability in the susceptibilities of the different organisms to the tested compounds. Staphylococcus aureus was the most resistant organism while Candida albicans was the most sensitive. Some compounds showed both antibacterial and antifungal activity, while others showed antibacterial activity with no antifungal activity and vice versa. Compound XIVe was the most active against both bacteria and fungi, while compounds Xe, XIIf, XIVa and XIVd showed a moderate activity

Synthesis and antimicrobial evaluation of certain purine, benzothiazole and thiazole systems substituted with dialkylaminoalkyl-o-cresols

Novel series of dialkylaminoalkyl-o-cresols incorporated with purine nucleus 2a–b, benzothiazole nucleus 5a–b, 8a–b and thiazole nucleus 11a–d, 13a–d were synthesized through Mannich reaction. Structures of the newly synthesized compounds have been deduced on the basis of elemental analysis and spectral data. Antimicrobial activity evaluation was carried out for all synthesized compounds; most of them exerted comparable activity to ciprofloxacin and flucanazole. The thiazole derivatives 11a, 13c, 13d are the most potent compounds