Studies on a novel oxo-vanadium(V) complex of a tridentate ONO Schiff base ligand: Synthesis, characterization, X-ray crystal structure, Hirshfeld surface analysis, biological and catalytic activity

This study reports the successful synthesis and characterization of a novel oxovanadium(V) complex, [VO(L) (MeOH)(MeO)], prepared from 2-hydroxy-3-methoxybenzaldehyde and 2-methyl-3-aminoquinazoline. To elucidate the structure of the complex, we employed comprehensive characterization techniques such as CHN analysis, molar conductivity measurements, FT-IR, 1 H NMR, UV-Vis spectroscopy, and single-crystal X-ray diffraction. The X-ray analysis confirmed an octahedral geometry around the V(V) center, coordinated with donor atoms from the deprotonated Schiff base ligand, an oxido group, a methanol molecule, and a methoxy group. Hirshfeld surface analysis was employed to evaluate intermolecular interactions. Furthermore, the complex exhibited impressively efficient catalytic activity in glucose oxidation under mild conditions (aqueous solution, room temperature, O2 oxidant), achieving a conversion rate of 98 %. Additionally, the antibacterial activity of the ligand and complex against various bacterial strains, including Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus cereus, was evaluated. The results demonstrated promising antibacterial potential of the [VO(L)(MeOH)(MeO)] complex, particularly against E. coli, P. aeruginosa, and B. cereus. These findings suggest potential applications of this new oxovanadium(V) complex in both catalysis and antibacterial treatment

Knowledge, attitude, and practices of pediatricians about children’s oral health

BACKGROUND AND AIM: Many pediatric oral diseases are preventable if physicians recognize and encourage preventive care and refer patients to dentists whenever necessary. Parents usually visit pediatricians for routine care during the first few years of a child’s life. Therefore, pediatricians have can assist dental professionals by educating parents to maintain their children's oral health. The main objective of this study was to determine knowledge, attitude, and practices of pediatricians about the oral disease prevention. METHODS: A piloted questionnaire was completed by volunteer pediatricians and pediatric residents in Kerman, Iran. It comprised a series of questions including sociodemographic and practice characteristics, knowledge about the risk factors for oral diseases, attitude toward oral disease prevention, practicing preventive care for oral diseases, and information about oral diseases. RESULTS: Overall, 60 subjects participated in the study. Less than half of the respondents knew all the main risk factors of dental caries, gingivitis, and malocclusion. There was also a positive attitude that caries can be prevented (100%). Less than 10% of the participants prescribed dietary fluoride supplements for their patients. CONCLUSIONS: Although we found inadequate knowledge about oral and dental diseases among pediatricians, the majority of our subjects believed that they had an important responsibility in preventing oral diseases. KEY WORDS: Oral Health, Children, Pediatrician, Preventive Car

“A Comparative Analysis of Codification of European Civil Code and Unified Islamic Civil Code: Challenges and Solutions

Globalization of law is an incontestable reality. It is a major concern, which can be justified not only from structural, conceptual and legal values perspectives, but also in terms of the legislative patterning realm. Laws of Islamic Nations cannot remain unaffected from this reality. The basis of viable regulation and legal conceptions in European systems, and generally in the West, has a humane rationality nature. Thus, from substantive perspective, globalization can be considered to be a kind of threat to laws of Islamic Nations, since in Islamic law, humane rationality is not the sole basis for the credibility of legal values, conceptions and structures. Here, it is assumed that globalization can be viewed as an opportunity, and the adoption of Unified Islamic Civil Code by following European Civil Code pattern may be regarded as an example of this opportunity. Nevertheless, the establishment of European Civil Code and an Islamic Civil Code encounters many challenges. By analysing these challenges, this article aims to present some solutions

Knowledge, attitude, and practices of pediatricians about children’s oral health

BACKGROUND: Many pediatric oral diseases are preventable if physicians recognize and encourage preventive care and refer patients to dentists whenever necessary. Parents usually visit pediatricians for routine care during the first few years of a child’s life. Therefore, pediatricians have can assist dental professionals by educating parents to maintain their children's oral health. The main objective of this study was to determine knowledge, attitude, and practices of pediatricians about the oral disease prevention. METHODS: A pilot questionnaire was completed by volunteer pediatricians and pediatric residents in Kerman, Iran. It comprised a series of questions including sociodemographic and practice characteristics, knowledge about the risk factors for oral diseases, attitude toward oral disease prevention, practicing preventive care for oral diseases, and information about oral diseases. RESULTS: Overall, 60 subjects participated in the study. Less than half of the respondents knew all the main risk factors of dental caries, gingivitis, and malocclusion. There was also a positive attitude that caries can be prevented (100%). Less than 10% of the participants prescribed dietary fluoride supplements for their patients. CONCLUSIONS: Although we found inadequate knowledge about oral and dental diseases among pediatricians, the majority of our subjects believed that they had an important responsibility in preventing oral diseases

Protective Effects of Achillea millefolium Extract on Myocardial Infarction Induced by Isoproterenol in Rats

Background and purpose: In recent years, natural products have been widely used in traditional medicine to treat cardiovascular diseases. The aim of this study was to determine the cardioprotective effect of Achillea millefolium extract against isoproterenol (ISO) induced myocardial infarction (MI) in rats. Materials and methods: In this experimental study, the aerial parts of the plant were extracted with ethanol through maceration and subjected to colorimetry to determine flavonoids and phenolic compounds. The rats were treated with A.millefolium (100, 200, 400 mg/kg) for 1۴ days. MI was induced by intraperitoneal injection of isoproterenol (85 mg/kg) at days 15 and 16. Twenty-four hours after the second dose of ISO injection, the rats were anaesthetized and electrocardiographic (ECG) parameters were recorded and blood samples were obtained for biochemical assay. Results: Isoproterenol increased heart weight/body weight ratio, serum levels of CK-MB, LDH, MDA, and decreased serum levels of total antioxidant capacity. In addition, it produced ST-segment elevation, decreased R-wave amplitude, and increased QT interval and heart rate. Pretreatment with A. millefolium at different doses prevented ISO-induced changes. Phenolic and flavonoid contents were 57.37 mg gallic acid/g DW and 6.74 mg quercetin /g DW, respectively. The IC50 value of the extract was 81.54 μg/ ml in DPPH method. Conclusion: The study showed that yarrow extract (A. millefolium) with its antioxidant properties protects the heart from ischemic damage caused by isoproterenol. © 2022, Mazandaran University of Medical Sciences. All rights reserved

Protective Effects of Achillea millefolium Extract on Myocardial Infarction Induced by Isoproterenol in Rats

Background and purpose: In recent years, natural products have been widely used in traditional medicine to treat cardiovascular diseases. The aim of this study was to determine the cardioprotective effect of Achillea millefolium extract against isoproterenol (ISO) induced myocardial infarction (MI) in rats. Materials and methods: In this experimental study, the aerial parts of the plant were extracted with ethanol through maceration and subjected to colorimetry to determine flavonoids and phenolic compounds. The rats were treated with A.millefolium (100, 200, 400 mg/kg) for 14 days. MI was induced by intraperitoneal injection of isoproterenol (85 mg/kg) at days 15 and 16. Twenty-four hours after the second dose of ISO injection, the rats were anaesthetized and electrocardiographic (ECG) parameters were recorded and blood samples were obtained for biochemical assay. Results: Isoproterenol increased heart weight/body weight ratio, serum levels of CK-MB, LDH, MDA, and decreased serum levels of total antioxidant capacity. In addition, it produced ST-segment elevation, decreased R-wave amplitude, and increased QT interval and heart rate. Pretreatment with A. millefolium at different doses prevented ISO-induced changes. Phenolic and flavonoid contents were 57.37 mg gallic acid/g DW and 6.74 mg quercetin /g DW, respectively. The IC50 value of the extract was 81.54 μg/ ml in DPPH method. Conclusion: The study showed that yarrow extract (A. millefolium) with its antioxidant properties protects the heart from ischemic damage caused by isoproterenol